Susan V. Brooks Department of Molecular & Integrative Physiology University of Michigan Medical School Biography Publications Institution JoVE Articles Susan V. Brooks has not added a biography. If you are Susan V. Brooks and would like to personalize this page please email our Author Liaison for assistance. Publications Neuron Specific Reduction in CuZnSOD is Not Sufficient to Initiate a Full Sarcopenia Phenotype Redox Biology. Apr, 2015 | Pubmed ID: 25917273 Age Affects the Contraction-induced Mitochondrial Redox Response in Skeletal Muscle Frontiers in Physiology. 2015 | Pubmed ID: 25698975 Ten Weeks of Treadmill Running Decreases Stiffness and Increases Collagen Turnover in Tendons of Old Mice Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Jan, 2015 | Pubmed ID: 25640809 Intrinsic Stiffness of Extracellular Matrix Increases with Age in Skeletal Muscles of Mice Journal of Applied Physiology (Bethesda, Md. : 1985). Aug, 2014 | Pubmed ID: 24994884 RNAi-mediated Gene Silencing of Mutant Myotilin Improves Myopathy in LGMD1A Mice Molecular Therapy. Nucleic Acids. 2014 | Pubmed ID: 24781192 Neuron-specific Expression of CuZnSOD Prevents the Loss of Muscle Mass and Function That Occurs in Homozygous CuZnSOD-knockout Mice FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2014 | Pubmed ID: 24378874 Murine Fig4 is Dispensable for Muscle Development but Required for Muscle Function Skeletal Muscle. Sep, 2013 | Pubmed ID: 24004519 Reactive Oxygen Species Generation is Not Different During Isometric and Lengthening Contractions of Mouse Muscle American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Oct, 2013 | Pubmed ID: 23948772 The Role of Oxidative Stress in Nervous System Aging PloS One. 2013 | Pubmed ID: 23844146 Targeted Inhibition of TGF-β Results in an Initial Improvement but Long Term Deficit in Force Production After Contraction-induced Skeletal Muscle Injury Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2013 | Pubmed ID: 23766498 CuZnSOD Gene Deletion Targeted to Skeletal Muscle Leads to Loss of Contractile Force but Does Not Cause Muscle Atrophy in Adult Mice FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2013 | Pubmed ID: 23729587 Eccentric Exercise in Aging and Diseased Skeletal Muscle: Good or Bad? Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2013 | Pubmed ID: 23471953 Age-related Changes in Structure and Extracellular Matrix Protein Expression Levels in Rat Tendons Age (Dordrecht, Netherlands). Jan, 2013 | Pubmed ID: 23354684 Muscle-specific Expression of LARGE Restores Neuromuscular Transmission Deficits in Dystrophic LARGE(myd) Mice Human Molecular Genetics. Feb, 2013 | Pubmed ID: 23222475 Weakness of Whole Muscles in Mice Deficient in Cu, Zn Superoxide Dismutase is Not Explained by Defects at the Level of the Contractile Apparatus Age (Dordrecht, Netherlands). Aug, 2013 | Pubmed ID: 22696118 Rapamycin Slows Aging in Mice Aging Cell. May, 2012 | Pubmed ID: 22587563 Oxidative Stress and Successful Antioxidant Treatment in Models of RYR1-related Myopathy Brain : a Journal of Neurology. Apr, 2012 | Pubmed ID: 22418739 Transforming Growth Factor-beta Induces Skeletal Muscle Atrophy and Fibrosis Through the Induction of Atrogin-1 and Scleraxis Muscle & Nerve. Jan, 2012 | Pubmed ID: 22190307 Neb: a Zebrafish Model of Nemaline Myopathy Due to Nebulin Mutation Disease Models & Mechanisms. May, 2012 | Pubmed ID: 22159874 Physiological Loading of Tendons Induces Scleraxis Expression in Epitenon Fibroblasts Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Apr, 2012 | Pubmed ID: 21913219 Skeletal Muscle Weakness Due to Deficiency of CuZn-superoxide Dismutase is Associated with Loss of Functional Innervation American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Nov, 2011 | Pubmed ID: 21900648 Regional Stiffening with Aging in Tibialis Anterior Tendons of Mice Occurs Independent of Changes in Collagen Fibril Morphology Journal of Applied Physiology (Bethesda, Md. : 1985). Oct, 2011 | Pubmed ID: 21737825 Decreased Specific Force and Power Production of Muscle Fibers from Myostatin-deficient Mice Are Associated with a Suppression of Protein Degradation Journal of Applied Physiology (Bethesda, Md. : 1985). Jul, 2011 | Pubmed ID: 21565991 Reactive Oxygen Species on Bone Mineral Density and Mechanics in Cu,Zn Superoxide Dismutase (Sod1) Knockout Mice Biochemical and Biophysical Research Communications. Dec, 2010 | Pubmed ID: 21056548 The Age-related Failure of Adaptive Responses to Contractile Activity in Skeletal Muscle is Mimicked in Young Mice by Deletion of Cu,Zn Superoxide Dismutase Aging Cell. Dec, 2010 | Pubmed ID: 20883524 Increased Superoxide in Vivo Accelerates Age-associated Muscle Atrophy Through Mitochondrial Dysfunction and Neuromuscular Junction Degeneration FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2010 | Pubmed ID: 20040516 Inhibition of Calpain Prevents Muscle Weakness and Disruption of Sarcomere Structure During Hindlimb Suspension Journal of Applied Physiology (Bethesda, Md. : 1985). Jan, 2010 | Pubmed ID: 19892928 Conditional Knockout of Mn-SOD Targeted to Type IIB Skeletal Muscle Fibers Increases Oxidative Stress and is Sufficient to Alter Aerobic Exercise Capacity American Journal of Physiology. Cell Physiology. Dec, 2009 | Pubmed ID: 19776389 The Aging of Elite Male Athletes: Age-related Changes in Performance and Skeletal Muscle Structure and Function Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine. Nov, 2008 | Pubmed ID: 19001883 Repeated Bouts of Aerobic Exercise Lead to Reductions in Skeletal Muscle Free Radical Generation and Nuclear Factor KappaB Activation The Journal of Physiology. Aug, 2008 | Pubmed ID: 18591188 Force Deficits and Breakage Rates After Single Lengthening Contractions of Single Fast Fibers from Unconditioned and Conditioned Muscles of Young and Old Rats American Journal of Physiology. Cell Physiology. Jul, 2008 | Pubmed ID: 18508906 Neutrophil Accumulation Following Passive Stretches Contributes to Adaptations That Reduce Contraction-induced Skeletal Muscle Injury in Mice Journal of Applied Physiology (Bethesda, Md. : 1985). Apr, 2008 | Pubmed ID: 18276901 Direct Observation of Failing Fibers in Muscles of Dystrophic Mice Provides Mechanistic Insight into Muscular Dystrophy American Journal of Physiology. Cell Physiology. Feb, 2008 | Pubmed ID: 18171725 Age-related Changes in the Structure and Function of Skeletal Muscles Clinical and Experimental Pharmacology & Physiology. Nov, 2007 | Pubmed ID: 17880359 Protection from Contraction-induced Injury Provided to Skeletal Muscles of Young and Old Mice by Passive Stretch is Not Due to a Decrease in Initial Mechanical Damage The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Jun, 2006 | Pubmed ID: 16799132 Activation of Akt As a Potential Mediator of Adaptations That Reduce Muscle Injury Medicine and Science in Sports and Exercise. Jun, 2006 | Pubmed ID: 16775545 Muscles of Mice Deficient in Alpha-sarcoglycan Maintain Large Masses and Near Control Force Values Throughout the Life Span Physiological Genomics. Jul, 2005 | Pubmed ID: 15886330 Susceptibility to Sarcomere Injury Induced by Single Stretches of Maximally Activated Muscles of Mdx Mice Journal of Applied Physiology (Bethesda, Md. : 1985). Feb, 2004 | Pubmed ID: 14715682 Current Topics for Teaching Skeletal Muscle Physiology Advances in Physiology Education. Dec, 2003 | Pubmed ID: 14627615 Passive Stretches Protect Skeletal Muscle of Adult and Old Mice from Lengthening Contraction-induced Injury The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Jul, 2003 | Pubmed ID: 12865474 Functional Correction of Adult Mdx Mouse Muscle Using Gutted Adenoviral Vectors Expressing Full-length Dystrophin Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002 | Pubmed ID: 12271128 Muscle Inflammatory Cells After Passive Stretches, Isometric Contractions, and Lengthening Contractions Journal of Applied Physiology (Bethesda, Md. : 1985). May, 2002 | Pubmed ID: 11960936 Modular Flexibility of Dystrophin: Implications for Gene Therapy of Duchenne Muscular Dystrophy Nature Medicine. Mar, 2002 | Pubmed ID: 11875496 Measurement of Maximum Isometric Force Generated by Permeabilized Skeletal Muscle Fibers Stuart M. Roche1, Jonathan P. Gumucio1,2, Susan V. Brooks2,3, Christopher L. Mendias1,2, Dennis R. Claflin3,4 1Department of Orthopaedic Surgery, University of Michigan Medical School, 2Department of Molecular & Integrative Physiology, University of Michigan Medical School, 3Department of Biomedical Engineering, University of Michigan Medical School, 4Department of Surgery, Section of Plastic Surgery, University of Michigan Medical School JoVE 52695 Bio-ingénierie Force Measurement During Contraction to Assess Muscle Function in Zebrafish Larvae Darcée D. Sloboda1, Dennis R. Claflin1,2, James J. Dowling3, Susan V. Brooks1,4 1Department of Biomedical Engineering, University of Michigan, 2Department of Surgery, Section of Plastic Surgery, University of Michigan, 3Departments of Pediatrics and Neurology, University of Michigan, 4Department of Molecular and Integrative Physiology, University of Michigan JoVE 50539 Biologie
Measurement of Maximum Isometric Force Generated by Permeabilized Skeletal Muscle Fibers Stuart M. Roche1, Jonathan P. Gumucio1,2, Susan V. Brooks2,3, Christopher L. Mendias1,2, Dennis R. Claflin3,4 1Department of Orthopaedic Surgery, University of Michigan Medical School, 2Department of Molecular & Integrative Physiology, University of Michigan Medical School, 3Department of Biomedical Engineering, University of Michigan Medical School, 4Department of Surgery, Section of Plastic Surgery, University of Michigan Medical School JoVE 52695 Bio-ingénierie
Force Measurement During Contraction to Assess Muscle Function in Zebrafish Larvae Darcée D. Sloboda1, Dennis R. Claflin1,2, James J. Dowling3, Susan V. Brooks1,4 1Department of Biomedical Engineering, University of Michigan, 2Department of Surgery, Section of Plastic Surgery, University of Michigan, 3Departments of Pediatrics and Neurology, University of Michigan, 4Department of Molecular and Integrative Physiology, University of Michigan JoVE 50539 Biologie