Thomas H Gillingwater Centre for Integrative Physiology University of Edinburgh Biography Publications Institution JoVE Articles Thomas H Gillingwater has not added a biography. If you are Thomas H Gillingwater and would like to personalize this page please email our Author Liaison for assistance. Publications SMN-dependent Intrinsic Defects in Schwann Cells in Mouse Models of Spinal Muscular Atrophy Human Molecular Genetics. Dec, 2013 | Pubmed ID: 24301677 Label-free Proteomics Identifies Calreticulin and GRP75/Mortalin As Peripherally Accessible Protein Biomarkers for Spinal Muscular Atrophy Genome Medicine. Oct, 2013 | Pubmed ID: 24134804 Executive Deficits, Not Processing Speed Relates to Abnormalities in Distinct Prefrontal Tracts in Amyotrophic Lateral Sclerosis Brain : a Journal of Neurology. Nov, 2013 | Pubmed ID: 24056536 Total Protein Analysis As a Reliable Loading Control for Quantitative Fluorescent Western Blotting PloS One. 2013 | Pubmed ID: 24023619 Studying Synapses in Human Brain with Array Tomography and Electron Microscopy Nature Protocols. 2013 | Pubmed ID: 23787894 Increasing SMN Levels Using the Histone Deacetylase Inhibitor SAHA Ameliorates Defects in Skeletal Muscle Microvasculature in a Mouse Model of Severe Spinal Muscular Atrophy Neuroscience Letters. Jun, 2013 | Pubmed ID: 23583590 Effect of Limb Lengthening on Internodal Length and Conduction Velocity of Peripheral Nerve The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2013 | Pubmed ID: 23467369 Quantitative Tractography and Tract Shape Modeling in Amyotrophic Lateral Sclerosis Journal of Magnetic Resonance Imaging : JMRI. Nov, 2013 | Pubmed ID: 23450730 Spinal Muscular Atrophy: Going Beyond the Motor Neuron Trends in Molecular Medicine. Jan, 2013 | Pubmed ID: 23228902 Morphological Characteristics of Motor Neurons Do Not Determine Their Relative Susceptibility to Degeneration in a Mouse Model of Severe Spinal Muscular Atrophy PloS One. 2012 | Pubmed ID: 23285108 Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration in Vivo PLoS Genetics. 2012 | Pubmed ID: 22952455 WldS Prevents Axon Degeneration Through Increased Mitochondrial Flux and Enhanced Mitochondrial Ca2+ Buffering Current Biology : CB. Apr, 2012 | Pubmed ID: 22425157 Altered Maturation of the Primary Somatosensory Cortex in a Mouse Model of Fragile X Syndrome Human Molecular Genetics. May, 2012 | Pubmed ID: 22328088 Development of a Supported Self-directed Learning Approach for Anatomy Education Anatomical Sciences Education. Mar-Apr, 2012 | Pubmed ID: 22223487 Using Induced Pluripotent Stem Cells (iPSC) to Model Human Neuromuscular Connectivity: Promise or Reality? Journal of Anatomy. Feb, 2012 | Pubmed ID: 22133357 Targeting Synaptic Pathology in Multiple Sclerosis: Fingolimod to the Rescue? British Journal of Pharmacology. Feb, 2012 | Pubmed ID: 21806598 Morphologic and Functional Correlates of Synaptic Pathology in the Cathepsin D Knockout Mouse Model of Congenital Neuronal Ceroid Lipofuscinosis Journal of Neuropathology and Experimental Neurology. Dec, 2011 | Pubmed ID: 22082660 Reversible Molecular Pathology of Skeletal Muscle in Spinal Muscular Atrophy Human Molecular Genetics. Nov, 2011 | Pubmed ID: 21840928 The Contribution of Mouse Models to Understanding the Pathogenesis of Spinal Muscular Atrophy Disease Models & Mechanisms. Jul, 2011 | Pubmed ID: 21708901 ApoE Isoform-specific Regulation of Regeneration in the Peripheral Nervous System Human Molecular Genetics. Jun, 2011 | Pubmed ID: 21478199 Induction of Cell Stress in Neurons from Transgenic Mice Expressing Yellow Fluorescent Protein: Implications for Neurodegeneration Research PloS One. 2011 | Pubmed ID: 21408118 The Response of Neuromuscular Junctions to Injury is Developmentally Regulated FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2011 | Pubmed ID: 21228222 Synaptic Protection in the Brain of WldS Mice Occurs Independently of Age but is Sensitive to Gene-dose PloS One. 2010 | Pubmed ID: 21124744 SMN Deficiency Disrupts Brain Development in a Mouse Model of Severe Spinal Muscular Atrophy Human Molecular Genetics. Nov, 2010 | Pubmed ID: 20705736 Age-related Motor Neuron Degeneration in DNA Repair-deficient Ercc1 Mice Acta Neuropathologica. Oct, 2010 | Pubmed ID: 20602234 Pre-symptomatic Development of Lower Motor Neuron Connectivity in a Mouse Model of Severe Spinal Muscular Atrophy Human Molecular Genetics. Feb, 2010 | Pubmed ID: 19884170 Murine Cathepsin D Deficiency is Associated with Dysmyelination/myelin Disruption and Accumulation of Cholesteryl Esters in the Brain Journal of Neurochemistry. Jan, 2010 | Pubmed ID: 19845830 Alternative Splicing Events Are a Late Feature of Pathology in a Mouse Model of Spinal Muscular Atrophy PLoS Genetics. Dec, 2009 | Pubmed ID: 20019802 Expression of the Neuroprotective Slow Wallerian Degeneration (WldS) Gene in Non-neuronal Tissues BMC Neuroscience. 2009 | Pubmed ID: 20015399 Molecular Correlates of Axonal and Synaptic Pathology in Mouse Models of Batten Disease Human Molecular Genetics. Nov, 2009 | Pubmed ID: 19640925 Transcriptional Regulation of the AP-1 and Nrf2 Target Gene Sulfiredoxin Molecules and Cells. Mar, 2009 | Pubmed ID: 19326073 Protein Product of CLN6 Gene Responsible for Variant Late-onset Infantile Neuronal Ceroid Lipofuscinosis Interacts with CRMP-2 Journal of Neuroscience Research. Jul, 2009 | Pubmed ID: 19235893 The Importance of Exposure to Human Material in Anatomical Education: a Philosophical Perspective Anatomical Sciences Education. Nov-Dec, 2008 | Pubmed ID: 19109856 Loss of Translation Elongation Factor (eEF1A2) Expression in Vivo Differentiates Between Wallerian Degeneration and Dying-back Neuronal Pathology Journal of Anatomy. Dec, 2008 | Pubmed ID: 19094180 MGluR5 Regulates Glutamate-dependent Development of the Mouse Somatosensory Cortex The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2008 | Pubmed ID: 19052194 Identity, Developmental Restriction and Reactivity of Extralaminar Cells Capping Mammalian Neuromuscular Junctions Journal of Cell Science. Dec, 2008 | Pubmed ID: 19001504 Modified Cell Cycle Status in a Mouse Model of Altered Neuronal Vulnerability (slow Wallerian Degeneration; Wlds) Genome Biology. 2008 | Pubmed ID: 18570652 Rapid Loss of Motor Nerve Terminals Following Hypoxia-reperfusion Injury Occurs Via Mechanisms Distinct from Classic Wallerian Degeneration Journal of Anatomy. Jun, 2008 | Pubmed ID: 18510509 VCP Binding Influences Intracellular Distribution of the Slow Wallerian Degeneration Protein, Wld(S) Molecular and Cellular Neurosciences. Jul, 2008 | Pubmed ID: 18468455 VAPB Interacts with and Modulates the Activity of ATF6 Human Molecular Genetics. Jun, 2008 | Pubmed ID: 18263603 A Neurological Phenotype in Mice with DNA Repair Gene Ercc1 Deficiency DNA Repair. Feb, 2008 | Pubmed ID: 18221731 Synaptic Changes in the Thalamocortical System of Cathepsin D-deficient Mice: a Model of Human Congenital Neuronal Ceroid-lipofuscinosis Journal of Neuropathology and Experimental Neurology. Jan, 2008 | Pubmed ID: 18091563 Selective Vulnerability of Motor Neurons and Dissociation of Pre- and Post-synaptic Pathology at the Neuromuscular Junction in Mouse Models of Spinal Muscular Atrophy Human Molecular Genetics. Apr, 2008 | Pubmed ID: 18065780 Design of a Novel Quantitative PCR (QPCR)-based Protocol for Genotyping Mice Carrying the Neuroprotective Wallerian Degeneration Slow (Wlds) Gene Molecular Neurodegeneration. 2007 | Pubmed ID: 17971231 Differential Proteomics Analysis of Synaptic Proteins Identifies Potential Cellular Targets and Protein Mediators of Synaptic Neuroprotection Conferred by the Slow Wallerian Degeneration (Wlds) Gene Molecular & Cellular Proteomics : MCP. Aug, 2007 | Pubmed ID: 17470424 Synaptic Vulnerability in Neurodegenerative Disease Journal of Neuropathology and Experimental Neurology. Aug, 2006 | Pubmed ID: 16896307 Delayed Synaptic Degeneration in the CNS of Wlds Mice After Cortical Lesion Brain : a Journal of Neurology. Jun, 2006 | Pubmed ID: 16738060 Involvement of Protein Kinase A in Patterning of the Mouse Somatosensory Cortex The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2006 | Pubmed ID: 16707791 Synaptic Ras GTPase Activating Protein Regulates Pattern Formation in the Trigeminal System of Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2006 | Pubmed ID: 16452659 The Neuroprotective WldS Gene Regulates Expression of PTTG1 and Erythroid Differentiation Regulator 1-like Gene in Mice and Human Cells Human Molecular Genetics. Feb, 2006 | Pubmed ID: 16403805 Progressive Loss of Motor Neuron Function in Wasted Mice: Effects of a Spontaneous Null Mutation in the Gene for the EEF1 A2 Translation Factor Journal of Neuropathology and Experimental Neurology. Apr, 2005 | Pubmed ID: 15835265 A Rat Model of Slow Wallerian Degeneration (WldS) with Improved Preservation of Neuromuscular Synapses The European Journal of Neuroscience. Jan, 2005 | Pubmed ID: 15654865 The Slow Wallerian Degeneration Gene, WldS, Inhibits Axonal Spheroid Pathology in Gracile Axonal Dystrophy Mice Brain : a Journal of Neurology. Feb, 2005 | Pubmed ID: 15644421 Progressive Abnormalities in Skeletal Muscle and Neuromuscular Junctions of Transgenic Mice Expressing the Huntington's Disease Mutation The European Journal of Neuroscience. Dec, 2004 | Pubmed ID: 15579164 Myo-GDNF Increases Non-functional Polyinnervation of Reinnervated Mouse Muscle Neuroreport. Jan, 2004 | Pubmed ID: 15106825 Axotomy-dependent and -independent Synapse Elimination in Organ Cultures of Wld(s) Mutant Mouse Skeletal Muscle Journal of Neuroscience Research. Apr, 2004 | Pubmed ID: 15048930 Neuroprotection After Transient Global Cerebral Ischemia in Wld(s) Mutant Mice Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jan, 2004 | Pubmed ID: 14688617 The Relationship of Neuromuscular Synapse Elimination to Synaptic Degeneration and Pathology: Insights from WldS and Other Mutant Mice Journal of Neurocytology. Jun-Sep, 2003 | Pubmed ID: 15034273 Ultrastructural Correlates of Synapse Withdrawal at Axotomized Neuromuscular Junctions in Mutant and Transgenic Mice Expressing the Wld Gene Journal of Anatomy. Sep, 2003 | Pubmed ID: 14529044 Age-dependent Synapse Withdrawal at Axotomised Neuromuscular Junctions in Wld(s) Mutant and Ube4b/Nmnat Transgenic Mice The Journal of Physiology. Sep, 2002 | Pubmed ID: 12231635 Dissection of the Transversus Abdominis Muscle for Whole-mount Neuromuscular Junction Analysis Lyndsay Murray1, Thomas H Gillingwater2, Rashmi Kothary1 1Regenerative Medicine Program, Ottawa Hospital Research Institute, 2Centre for Integrative Physiology, University of Edinburgh JoVE 51162 Neurosciences
Dissection of the Transversus Abdominis Muscle for Whole-mount Neuromuscular Junction Analysis Lyndsay Murray1, Thomas H Gillingwater2, Rashmi Kothary1 1Regenerative Medicine Program, Ottawa Hospital Research Institute, 2Centre for Integrative Physiology, University of Edinburgh JoVE 51162 Neurosciences