Tomas Olsson Department of Clinical Neuroscience, Neuroimmunology Unit, Center for Molecular Medicine Karolinska Institutet Biography Publications Institution JoVE Articles Tomas Olsson has not added a biography. If you are Tomas Olsson and would like to personalize this page please email our Author Liaison for assistance. Publications Cerebrospinal Fluid Biomarkers As a Measure of Disease Activity and Treatment Efficacy in Relapsing-remitting Multiple Sclerosis Journal of Neurochemistry. Oct, 2016 | Pubmed ID: 27787906 Modeling Strategies for Quantification of in Vivo 18F-AV1451 Binding in Patients with Tau Pathology Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Oct, 2016 | Pubmed ID: 27765859 Increased Basal Ganglia Binding of (18) F-AV-1451 in Patients with Progressive Supranuclear Palsy Movement Disorders : Official Journal of the Movement Disorder Society. Oct, 2016 | Pubmed ID: 27709757 IL-22 Binding Protein Regulates Murine Skin Inflammation Experimental Dermatology. Sep, 2016 | Pubmed ID: 27676439 Mendelian Randomization Shows a Causal Effect of Low Vitamin D on Multiple Sclerosis Risk Neurology. Genetics. Oct, 2016 | Pubmed ID: 27652346 Dynamic Response Genes in CD4+ T Cells Reveal a Network of Interactive Proteins That Classifies Disease Activity in Multiple Sclerosis Cell Reports. Sep, 2016 | Pubmed ID: 27626663 Multiple Sclerosis Risk Loci and Disease Severity in 7,125 Individuals from 10 Studies Neurology. Genetics. Aug, 2016 | Pubmed ID: 27540591 TGFβ Regulates Persistent Neuroinflammation by Controlling Th1 Polarization and ROS Production Via Monocyte-derived Dendritic Cells Glia. Nov, 2016 | Pubmed ID: 27479807 Absence of Systemic Oxidative Stress and Increased CSF Prostaglandin F2α in Progressive MS Neurology(R) Neuroimmunology & Neuroinflammation. Aug, 2016 | Pubmed ID: 27386506 T-cell Activation and HLA-regulated Response to Smoking in the Deep Airways of Patients with Multiple Sclerosis Clinical Immunology (Orlando, Fla.). Aug, 2016 | Pubmed ID: 27339331 Distinct Oligoclonal Band Antibodies in Multiple Sclerosis Recognize Ubiquitous Self-proteins Proceedings of the National Academy of Sciences of the United States of America. Jul, 2016 | Pubmed ID: 27325759 Effect of High-dose Vitamin D3 Supplementation on Antibody Responses Against Epstein-Barr Virus in Relapsing-remitting Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). Jun, 2016 | Pubmed ID: 27325604 Multiple Sclerosis Relapses Are Associated with Increased Fatigue and Reduced Health-related Quality of Life - A Post Hoc Analysis of the TEMSO and TOWER Studies Multiple Sclerosis and Related Disorders. May, 2016 | Pubmed ID: 27237754 Von Willebrand Factor Gene Variants Associate with Herpes Simplex Encephalitis PloS One. 2016 | Pubmed ID: 27224245 Autoantibody Targets in Vaccine-associated Narcolepsy Autoimmunity. May, 2016 | Pubmed ID: 27206786 Multiple Sclerosis and Risk of Young-adult-onset Hodgkin Lymphoma Neurology(R) Neuroimmunology & Neuroinflammation. Jun, 2016 | Pubmed ID: 27144218 Circulating MiR-150 in CSF is a Novel Candidate Biomarker for Multiple Sclerosis Neurology(R) Neuroimmunology & Neuroinflammation. Jun, 2016 | Pubmed ID: 27144214 Environmental Factors and Their Interactions with Risk Genotypes in MS Susceptibility Current Opinion in Neurology. Jun, 2016 | Pubmed ID: 27035899 Cerebrospinal Fluid Biomarkers of Inflammation and Degeneration As Measures of Fingolimod Efficacy in Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). Mar, 2016 | Pubmed ID: 27003946 High-intensity Resistance Training in Multiple Sclerosis - An Exploratory Study of Effects on Immune Markers in Blood and Cerebrospinal Fluid, and on Mood, Fatigue, Health-related Quality of Life, Muscle Strength, Walking and Cognition Journal of the Neurological Sciences. Mar, 2016 | Pubmed ID: 26944158 Anoctamin 2 Identified As an Autoimmune Target in Multiple Sclerosis Proceedings of the National Academy of Sciences of the United States of America. Feb, 2016 | Pubmed ID: 26862169 [New Techniques Can Radically Change Health Care] Lakartidningen. Feb, 2016 | Pubmed ID: 26859854 Pooled Safety and Tolerability Data from Four Placebo-controlled Teriflunomide Studies and Extensions Multiple Sclerosis and Related Disorders. Jan, 2016 | Pubmed ID: 26856952 Posterior Accumulation of Tau and Concordant Hypometabolism in an Early-Onset Alzheimer's Disease Patient with Presenilin-1 Mutation Journal of Alzheimer's Disease : JAD. 2016 | Pubmed ID: 26836192 Lipocalin-2 is Increased in Progressive Multiple Sclerosis and Inhibits Remyelination Neurology(R) Neuroimmunology & Neuroinflammation. Feb, 2016 | Pubmed ID: 26770997 The Expression of BAFF Is Controlled by IRF Transcription Factors Journal of Immunology (Baltimore, Md. : 1950). Jan, 2016 | Pubmed ID: 26590315 Rat Bone Marrow-derived Dendritic Cells Generated with GM-CSF/IL-4 or FLT3L Exhibit Distinct Phenotypical and Functional Characteristics Journal of Leukocyte Biology. Mar, 2016 | Pubmed ID: 26516183 Cerebrospinal Fluid Kynurenines in Multiple Sclerosis; Relation to Disease Course and Neurocognitive Symptoms Brain, Behavior, and Immunity. Jan, 2016 | Pubmed ID: 26189678 Pro-inflammatory Pattern of IgG1 Fc Glycosylation in Multiple Sclerosis Cerebrospinal Fluid Journal of Neuroinflammation. Dec, 2015 | Pubmed ID: 26683050 Translational Utility of Experimental Autoimmune Encephalomyelitis: Recent Developments Journal of Inflammation Research. 2015 | Pubmed ID: 26622189 A Validated Gene Regulatory Network and GWAS Identifies Early Regulators of T Cell-associated Diseases Science Translational Medicine. Nov, 2015 | Pubmed ID: 26560356 MOG-induced Experimental Autoimmune Encephalomyelitis in the Rat Species Triggers Anti-neurofascin Antibody Response That is Genetically Regulated Journal of Neuroinflammation. Oct, 2015 | Pubmed ID: 26511327 PML: The Dark Side of Immunotherapy in Multiple Sclerosis Trends in Pharmacological Sciences. Dec, 2015 | Pubmed ID: 26497099 Effect of Smoking Cessation on Multiple Sclerosis Prognosis JAMA Neurology. Oct, 2015 | Pubmed ID: 26348720 Class II HLA Interactions Modulate Genetic Risk for Multiple Sclerosis Nature Genetics. Oct, 2015 | Pubmed ID: 26343388 Fine Mapping of Bone Structure and Strength QTLs in Heterogeneous Stock Rat Bone. Dec, 2015 | Pubmed ID: 26297441 Cell Fusion Along the Anterior-Posterior Neuroaxis in Mice with Experimental Autoimmune Encephalomyelitis PloS One. 2015 | Pubmed ID: 26207625 γ-Secretase Directly Sheds the Survival Receptor BCMA from Plasma Cells Nature Communications. Jun, 2015 | Pubmed ID: 26065893 Complement Component C3 and Butyrylcholinesterase Activity Are Associated with Neurodegeneration and Clinical Disability in Multiple Sclerosis PloS One. 2015 | Pubmed ID: 25835709 The Role of Environment and Lifestyle in Determining the Risk of Multiple Sclerosis Current Topics in Behavioral Neurosciences. 2015 | Pubmed ID: 25707369 Chitinase 3-like 1: Prognostic Biomarker in Clinically Isolated Syndromes Brain : a Journal of Neurology. Apr, 2015 | Pubmed ID: 25688078 Genetic Variants Are Major Determinants of CSF Antibody Levels in Multiple Sclerosis Brain : a Journal of Neurology. Mar, 2015 | Pubmed ID: 25616667 The Immunoregulator Soluble TACI is Released by ADAM10 and Reflects B Cell Activation in Autoimmunity Journal of Immunology (Baltimore, Md. : 1950). Jan, 2015 | Pubmed ID: 25505277 Hexosylceramides As Intrathecal Markers of Worsening Disability in Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). Sep, 2015 | Pubmed ID: 25480867 Natalizumab Exerts a Suppressive Effect on Surrogates of B Cell Function in Blood and CSF Multiple Sclerosis (Houndmills, Basingstoke, England). Jul, 2015 | Pubmed ID: 25392339 β-Amyloid Peptides and Amyloid Plaques in Alzheimer's Disease Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Jan, 2015 | Pubmed ID: 25371168 Identity-by-descent Mapping in a Scandinavian Multiple Sclerosis Cohort European Journal of Human Genetics : EJHG. May, 2015 | Pubmed ID: 25159868 Signaling Networks in MS: a Systems-based Approach to Developing New Pharmacological Therapies Multiple Sclerosis (Houndmills, Basingstoke, England). Feb, 2015 | Pubmed ID: 25112814 A Cell Culture Model for Monitoring α-synuclein Cell-to-cell Transfer Neurobiology of Disease. May, 2015 | Pubmed ID: 25046995 Age-dependent Effects on the Treatment Response of Natalizumab in MS Patients Multiple Sclerosis (Houndmills, Basingstoke, England). Jan, 2015 | Pubmed ID: 24866201 Initial Lymphocyte Count and Low BMI May Affect Fingolimod-induced Lymphopenia Neurology. Dec, 2014 | Pubmed ID: 25361781 Interaction Between Passive Smoking and Two HLA Genes with Regard to Multiple Sclerosis Risk International Journal of Epidemiology. Dec, 2014 | Pubmed ID: 25324153 Multiple Sclerosis-associated IL2RA Polymorphism Controls GM-CSF Production in Human TH Cells Nature Communications. Oct, 2014 | Pubmed ID: 25278028 Obesity During Childhood and Adolescence Increases Susceptibility to Multiple Sclerosis After Accounting for Established Genetic and Environmental Risk Factors Obesity Research & Clinical Practice. Sep-Oct, 2014 | Pubmed ID: 25263833 Affinity Proteomic Profiling of Plasma, Cerebrospinal Fluid, and Brain Tissue Within Multiple Sclerosis Journal of Proteome Research. Nov, 2014 | Pubmed ID: 25231264 Oral Teriflunomide for Patients with a First Clinical Episode Suggestive of Multiple Sclerosis (TOPIC): a Randomised, Double-blind, Placebo-controlled, Phase 3 Trial The Lancet. Neurology. Oct, 2014 | Pubmed ID: 25192851 No Association Between Rheumatoid Arthritis, Amyotrophic Lateral Sclerosis, and Tumour Necrosis Factor Inhibitor Treatment Annals of the Rheumatic Diseases. Nov, 2014 | Pubmed ID: 25096786 Oligoclonal Band Phenotypes in MS Differ in Their HLA Class II Association, While Specific KIR Ligands at HLA Class I Show Association to MS in General Journal of Neuroimmunology. Sep, 2014 | Pubmed ID: 25037176 Neonatal Vitamin D Status and Risk of Multiple Sclerosis Annals of Neurology. Sep, 2014 | Pubmed ID: 24985080 Teriflunomide Reduces Relapses with Sequelae and Relapses Leading to Hospitalizations: Results from the TOWER Study Journal of Neurology. Sep, 2014 | Pubmed ID: 24972678 Identification of Candidate Risk Gene Variations by Whole-genome Sequence Analysis of Four Rat Strains Commonly Used in Inflammation Research BMC Genomics. May, 2014 | Pubmed ID: 24885425 Interferon Beta Treatment of Multiple Sclerosis Increases Serum Interleukin-7 Multiple Sclerosis (Houndmills, Basingstoke, England). Nov, 2014 | Pubmed ID: 24821684 JC Polyomavirus Infection is Strongly Controlled by Human Leucocyte Antigen Class II Variants PLoS Pathogens. Apr, 2014 | Pubmed ID: 24763718 Cerebrospinal Fluid JC Virus Antibody Index for Diagnosis of Natalizumab-associated Progressive Multifocal Leukoencephalopathy Annals of Neurology. Dec, 2014 | Pubmed ID: 24729444 HLA-A(∗)02, Gender and Tobacco Smoking, but Not Multiple Sclerosis, Affects the IgG Antibody Response Against Human Herpesvirus 6 Human Immunology. Jun, 2014 | Pubmed ID: 24662416 Oral Ponesimod in Relapsing-remitting Multiple Sclerosis: a Randomised Phase II Trial Journal of Neurology, Neurosurgery, and Psychiatry. Nov, 2014 | Pubmed ID: 24659797 Uncovering Cryptic Glycan Markers in Multiple Sclerosis (MS) and Experimental Autoimmune Encephalomyelitis (EAE) Drug Development Research. May, 2014 | Pubmed ID: 24648292 High-resolution Genome Screen for Bone Mineral Density in Heterogeneous Stock Rat Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jul, 2014 | Pubmed ID: 24643965 Smoking and Risk of Multiple Sclerosis: Evidence of Modification by NAT1 Variants Epidemiology (Cambridge, Mass.). Jul, 2014 | Pubmed ID: 24625537 Natural Polymorphisms in Tap2 Influence Negative Selection and CD4∶CD8 Lineage Commitment in the Rat PLoS Genetics. Feb, 2014 | Pubmed ID: 24586191 Integrated Genomic and Prospective Clinical Studies Show the Importance of Modular Pleiotropy for Disease Susceptibility, Diagnosis and Treatment Genome Medicine. 2014 | Pubmed ID: 24571673 Interaction Between Adolescent Obesity and HLA Risk Genes in the Etiology of Multiple Sclerosis Neurology. Mar, 2014 | Pubmed ID: 24500647 A/H1N1 Antibodies and TRIB2 Autoantibodies in Narcolepsy Patients Diagnosed in Conjunction with the Pandemrix Vaccination Campaign in Sweden 2009-2010 Journal of Autoimmunity. May, 2014 | Pubmed ID: 24485154 Oral Teriflunomide for Patients with Relapsing Multiple Sclerosis (TOWER): a Randomised, Double-blind, Placebo-controlled, Phase 3 Trial The Lancet. Neurology. Mar, 2014 | Pubmed ID: 24461574 Alcohol As a Modifiable Lifestyle Factor Affecting Multiple Sclerosis Risk JAMA Neurology. Mar, 2014 | Pubmed ID: 24395432 Fatty Fish Intake is Associated with Decreased Occurrence of Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). May, 2014 | Pubmed ID: 24158977 Teriflunomide Versus Subcutaneous Interferon Beta-1a in Patients with Relapsing Multiple Sclerosis: a Randomised, Controlled Phase 3 Trial Multiple Sclerosis (Houndmills, Basingstoke, England). May, 2014 | Pubmed ID: 24126064 Smoking and Risk of Treatment-induced Neutralizing Antibodies to Interferon β-1a Multiple Sclerosis (Houndmills, Basingstoke, England). Apr, 2014 | Pubmed ID: 23924603 Fine-mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects PLoS Genetics. Nov, 2013 | Pubmed ID: 24278027 Mortality Following a Brain Tumour Diagnosis in Patients with Multiple Sclerosis BMJ Open. Nov, 2013 | Pubmed ID: 24220114 Smoking and Multiple Sclerosis Susceptibility European Journal of Epidemiology. Nov, 2013 | Pubmed ID: 24146047 Analysis of Immune-related Loci Identifies 48 New Susceptibility Variants for Multiple Sclerosis Nature Genetics. Nov, 2013 | Pubmed ID: 24076602 Distinction and Temporal Stability of Conformational Epitopes on Myelin Oligodendrocyte Glycoprotein Recognized by Patients with Different Inflammatory Central Nervous System Diseases Journal of Immunology (Baltimore, Md. : 1950). Oct, 2013 | Pubmed ID: 24014878 Combining Genetic Mapping with Genome-wide Expression in Experimental Autoimmune Encephalomyelitis Highlights a Gene Network Enriched for T Cell Functions and Candidate Genes Regulating Autoimmunity Human Molecular Genetics. Dec, 2013 | Pubmed ID: 23900079 Teriflunomide Reduces Relapse-related Neurological Sequelae, Hospitalizations and Steroid Use Journal of Neurology. Oct, 2013 | Pubmed ID: 23852658 Association of Genetic Markers with CSF Oligoclonal Bands in Multiple Sclerosis Patients PloS One. 2013 | Pubmed ID: 23785401 Autoantibody Profiling in Multiple Sclerosis Using Arrays of Human Protein Fragments Molecular & Cellular Proteomics : MCP. Sep, 2013 | Pubmed ID: 23732997 Combined Sequence-based and Genetic Mapping Analysis of Complex Traits in Outbred Rats Nature Genetics. Jul, 2013 | Pubmed ID: 23708188 Antibody-based Profiling of Cerebrospinal Fluid Within Multiple Sclerosis Proteomics. Aug, 2013 | Pubmed ID: 23696371 Intense Inflammation and Nerve Damage in Early Multiple Sclerosis Subsides at Older Age: a Reflection by Cerebrospinal Fluid Biomarkers PloS One. 2013 | Pubmed ID: 23667585 Cerebrospinal Fluid Oligoclonal Bands Are Important in the Diagnosis of Multiple Sclerosis, Unreasonably Downplayed by the McDonald Criteria 2010: Yes Multiple Sclerosis (Houndmills, Basingstoke, England). May, 2013 | Pubmed ID: 23658235 Soluble IL7Rα Potentiates IL-7 Bioactivity and Promotes Autoimmunity Proceedings of the National Academy of Sciences of the United States of America. May, 2013 | Pubmed ID: 23610432 Oligoclonal Band Status in Scandinavian Multiple Sclerosis Patients is Associated with Specific Genetic Risk Alleles PloS One. 2013 | Pubmed ID: 23472185 Systemic Inflammation in Progressive Multiple Sclerosis Involves Follicular T-helper, Th17- and Activated B-cells and Correlates with Progression PloS One. 2013 | Pubmed ID: 23469245 Changes to Anti-JCV Antibody Levels in a Swedish National MS Cohort Journal of Neurology, Neurosurgery, and Psychiatry. Nov, 2013 | Pubmed ID: 23463870 Anti-JC Virus Antibody Prevalence in a Multinational Multiple Sclerosis Cohort Multiple Sclerosis (Houndmills, Basingstoke, England). Oct, 2013 | Pubmed ID: 23459571 Magnetic Resonance Imaging Outcomes from a Phase III Trial of Teriflunomide Multiple Sclerosis (Houndmills, Basingstoke, England). Sep, 2013 | Pubmed ID: 23447359 Imatinib Ameliorates Neuroinflammation in a Rat Model of Multiple Sclerosis by Enhancing Blood-brain Barrier Integrity and by Modulating the Peripheral Immune Response PloS One. 2013 | Pubmed ID: 23437178 Effects of Natalizumab Treatment on the Cerebrospinal Fluid Proteome of Multiple Sclerosis Patients Journal of Proteome Research. Mar, 2013 | Pubmed ID: 23339689 The DQB1 *03:02 HLA Haplotype is Associated with Increased Risk of Chronic Pain After Inguinal Hernia Surgery and Lumbar Disc Herniation Pain. Mar, 2013 | Pubmed ID: 23318129 CSF Inflammation and Axonal Damage Are Increased and Correlate in Progressive Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). Jun, 2013 | Pubmed ID: 23178691 Serum Levels of LIGHT in MS Multiple Sclerosis (Houndmills, Basingstoke, England). Jun, 2013 | Pubmed ID: 23037546 Low Serum Levels of Vitamin D in Idiopathic Inflammatory Myopathies Annals of the Rheumatic Diseases. Apr, 2013 | Pubmed ID: 22993226 Neurofascin As a Target for Autoantibodies in Peripheral Neuropathies Neurology. Dec, 2012 | Pubmed ID: 23100406 Lack of Replication of Interaction Between EBNA1 IgG and Smoking in Risk for Multiple Sclerosis Neurology. Sep, 2012 | Pubmed ID: 22933744 Expression of Ccl11 Associates with Immune Response Modulation and Protection Against Neuroinflammation in Rats PloS One. 2012 | Pubmed ID: 22815714 Intravenous Immunoglobulin Treatment of the Post-polio Syndrome: Sustained Effects on Quality of Life Variables and Cytokine Expression After One Year Follow Up Journal of Neuroinflammation. Jul, 2012 | Pubmed ID: 22776106 The Calcitonin Receptor Gene is a Candidate for Regulation of Susceptibility to Herpes Simplex Type 1 Neuronal Infection Leading to Encephalitis in Rat PLoS Pathogens. 2012 | Pubmed ID: 22761571 Pre-specified Subgroup Analyses of a Placebo-controlled Phase III Trial (TEMSO) of Oral Teriflunomide in Relapsing Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). Nov, 2012 | Pubmed ID: 22723573 Identification of Naturally Occurring Fatty Acids of the Myelin Sheath That Resolve Neuroinflammation Science Translational Medicine. Jun, 2012 | Pubmed ID: 22674551 Importance of Human Leukocyte Antigen (HLA) Class I and II Alleles on the Risk of Multiple Sclerosis PloS One. 2012 | Pubmed ID: 22586495 Functional Identification of Pathogenic Autoantibody Responses in Patients with Multiple Sclerosis Brain : a Journal of Neurology. Jun, 2012 | Pubmed ID: 22561643 Targeting Free Prostate-specific Antigen for in Vivo Imaging of Prostate Cancer Using a Monoclonal Antibody Specific for Unique Epitopes Accessible on Free Prostate-specific Antigen Alone Cancer Biotherapy & Radiopharmaceuticals. May, 2012 | Pubmed ID: 22489659 High Body Mass Index Before Age 20 is Associated with Increased Risk for Multiple Sclerosis in Both Men and Women Multiple Sclerosis (Houndmills, Basingstoke, England). Sep, 2012 | Pubmed ID: 22328681 Risk Stratification for Progressive Multifocal Leukoencephalopathy in Patients Treated with Natalizumab Multiple Sclerosis (Houndmills, Basingstoke, England). Feb, 2012 | Pubmed ID: 22312009 The Balance of Expression of PTPN22 Splice Forms is Significantly Different in Rheumatoid Arthritis Patients Compared with Controls Genome Medicine. Jan, 2012 | Pubmed ID: 22264340 Development of Heart Block in Children of SSA/SSB-autoantibody-positive Women is Associated with Maternal Age and Displays a Season-of-birth Pattern Annals of the Rheumatic Diseases. Mar, 2012 | Pubmed ID: 21953338 Shift Work at Young Age is Associated with Increased Risk for Multiple Sclerosis Annals of Neurology. Nov, 2011 | Pubmed ID: 22006815 Randomized Trial of Oral Teriflunomide for Relapsing Multiple Sclerosis The New England Journal of Medicine. Oct, 2011 | Pubmed ID: 21991951 The P.Arg63Trp Polymorphism Controls Vav1 Functions and Foxp3 Regulatory T Cell Development The Journal of Experimental Medicine. Oct, 2011 | Pubmed ID: 21948080 Genetic Risk and a Primary Role for Cell-mediated Immune Mechanisms in Multiple Sclerosis Nature. Aug, 2011 | Pubmed ID: 21833088 MRM Assay for Quantitation of Complement Components in Human Blood Plasma - a Feasibility Study on Multiple Sclerosis Journal of Proteomics. Dec, 2011 | Pubmed ID: 21703369 Detecting Oxysterols in the Human Circulation Nature Immunology. Jun, 2011 | Pubmed ID: 21685947 Alterations in KLRB1 Gene Expression and a Scandinavian Multiple Sclerosis Association Study of the KLRB1 SNP Rs4763655 European Journal of Human Genetics : EJHG. Oct, 2011 | Pubmed ID: 21610746 The Expression of VEGF-A is Down Regulated in Peripheral Blood Mononuclear Cells of Patients with Secondary Progressive Multiple Sclerosis PloS One. May, 2011 | Pubmed ID: 21573104 White Matter Disease: Roles of Anti-MOG Antibodies in Demyelinating Diseases Nature Reviews. Neurology. May, 2011 | Pubmed ID: 21537356 Functional Energetics of CD4+-cellular Immunity in Monoclonal Antibody-associated Progressive Multifocal Leukoencephalopathy in Autoimmune Disorders PloS One. 2011 | Pubmed ID: 21533133 Principles of a New Treatment Algorithm in Multiple Sclerosis Expert Review of Neurotherapeutics. Mar, 2011 | Pubmed ID: 21375441 Smoking and Two Human Leukocyte Antigen Genes Interact to Increase the Risk for Multiple Sclerosis Brain : a Journal of Neurology. Mar, 2011 | Pubmed ID: 21303861 Axonal Damage in Relapsing Multiple Sclerosis is Markedly Reduced by Natalizumab Annals of Neurology. Jan, 2011 | Pubmed ID: 21280078 A Swedish National Post-marketing Surveillance Study of Natalizumab Treatment in Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). Jun, 2011 | Pubmed ID: 21228027 Cerebrospinal Fluid CXCL13 in Multiple Sclerosis: a Suggestive Prognostic Marker for the Disease Course Multiple Sclerosis (Houndmills, Basingstoke, England). Mar, 2011 | Pubmed ID: 21135023 Osteopontin Concentrations Are Increased in Cerebrospinal Fluid During Attacks of Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). Jan, 2011 | Pubmed ID: 20921238 IL-22RA2 Associates with Multiple Sclerosis and Macrophage Effector Mechanisms in Experimental Neuroinflammation Journal of Immunology (Baltimore, Md. : 1950). Dec, 2010 | Pubmed ID: 21041731 Fine-mapping Resolves Eae23 into Two QTLs and Implicates ZEB1 As a Candidate Gene Regulating Experimental Neuroinflammation in Rat PloS One. Sep, 2010 | Pubmed ID: 20856809 Considerations on Discontinuing Natalizumab for the Treatment of Multiple Sclerosis Annals of Neurology. Sep, 2010 | Pubmed ID: 20818795 Influence of Perineurial Cells and Toll-like Receptors 2 and 9 on Herpes Simplex Type 1 Entry to the Central Nervous System in Rat Encephalitis PloS One. Aug, 2010 | Pubmed ID: 20806060 Maternal MHC Regulates Generation of Pathogenic Antibodies and Fetal MHC-encoded Genes Determine Susceptibility in Congenital Heart Block Journal of Immunology (Baltimore, Md. : 1950). Sep, 2010 | Pubmed ID: 20696861 Confirmation of Association Between Multiple Sclerosis and CYP27B1 European Journal of Human Genetics : EJHG. Dec, 2010 | Pubmed ID: 20648053 Vitamin D and Musculoskeletal Health, Cardiovascular Disease, Autoimmunity and Cancer: Recommendations for Clinical Practice Autoimmunity Reviews. Sep, 2010 | Pubmed ID: 20601202 TNF Production in Macrophages is Genetically Determined and Regulates Inflammatory Disease in Rats Journal of Immunology (Baltimore, Md. : 1950). Jul, 2010 | Pubmed ID: 20505148 Lack of Support for Association Between the KIF1B Rs10492972[C] Variant and Multiple Sclerosis Nature Genetics. Jun, 2010 | Pubmed ID: 20502484 Management of Postpolio Syndrome The Lancet. Neurology. Jun, 2010 | Pubmed ID: 20494327 Interleukin 18 Receptor 1 Expression Distinguishes Patients with Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). Sep, 2010 | Pubmed ID: 20354066 Multiple Sclerosis: Identification and Clinical Evaluation of Novel CSF Biomarkers Journal of Proteomics. Apr, 2010 | Pubmed ID: 20093204 Gene Expression Profiling in Multiple Sclerosis: a Disease of the Central Nervous System, but with Relapses Triggered in the Periphery? Neurobiology of Disease. Mar, 2010 | Pubmed ID: 19944761 A Rare Variant of the TYK2 Gene is Confirmed to Be Associated with Multiple Sclerosis European Journal of Human Genetics : EJHG. Apr, 2010 | Pubmed ID: 19888296 A Role for VAV1 in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis Science Translational Medicine. Dec, 2009 | Pubmed ID: 20368159 Alternative Splicing and Transcriptome Profiling of Experimental Autoimmune Encephalomyelitis Using Genome-wide Exon Arrays PloS One. Nov, 2009 | Pubmed ID: 19915720 Progressive Multifocal Leukoencephalopathy After Natalizumab Monotherapy The New England Journal of Medicine. Sep, 2009 | Pubmed ID: 19741229 Tobacco Smoking, but Not Swedish Snuff Use, Increases the Risk of Multiple Sclerosis Neurology. Sep, 2009 | Pubmed ID: 19720976 Identification of Gene Regions Regulating Inflammatory Microglial Response in the Rat CNS After Nerve Injury Journal of Neuroimmunology. Jul, 2009 | Pubmed ID: 19525015 Differential Expression, and Genetic Association, of CD58 in Swedish Multiple Sclerosis Patients Proceedings of the National Academy of Sciences of the United States of America. Jun, 2009 | Pubmed ID: 19497873 Differential Nerve Injury-induced Expression of MHC Class II in the Mouse Correlates to Genetic Variability in the Type I Promoter of C2ta Journal of Neuroimmunology. Jul, 2009 | Pubmed ID: 19481818 Altered Expression of T Cell Immunoglobulin-mucin (TIM) Molecules in Bronchoalveolar Lavage CD4+ T Cells in Sarcoidosis Respiratory Research. 2009 | Pubmed ID: 19480659 TLR Activation Induces TNF-alpha Production from Adult Neural Stem/progenitor Cells Journal of Immunology (Baltimore, Md. : 1950). Jun, 2009 | Pubmed ID: 19454685 Advanced Intercross Line Mapping Suggests That Ncf1 (ean6) Regulates Severity in an Animal Model of Guillain-barre Syndrome Journal of Immunology (Baltimore, Md. : 1950). Apr, 2009 | Pubmed ID: 19299744 Characterization of Multiple Sclerosis Candidate Gene Expression Kinetics in Rat Experimental Autoimmune Encephalomyelitis Journal of Neuroimmunology. May, 2009 | Pubmed ID: 19269041 Identification of Novel Candidate Protein Biomarkers for the Post-polio Syndrome - Implications for Diagnosis, Neurodegeneration and Neuroinflammation Journal of Proteomics. Jan, 2009 | Pubmed ID: 19100873 A Resource for the Simultaneous High-resolution Mapping of Multiple Quantitative Trait Loci in Rats: the NIH Heterogeneous Stock Genome Research. Jan, 2009 | Pubmed ID: 18971309 Contrasting Genetic Effects of Major Histocompatibility Complex on Ischemic Peripheral Nerve and Spinal Cord Injury in Female Rats Neuroscience Letters. Oct, 2008 | Pubmed ID: 18675884 Both MHC and Non-MHC Genes Regulate Development of Experimental Neuropathic Pain in Rats Neuroscience Letters. Sep, 2008 | Pubmed ID: 18640240 The Genetics of Multiple Sclerosis and Its Experimental Models Current Opinion in Neurology. Jun, 2008 | Pubmed ID: 18451707 Host Strain-dependent Difference in Susceptibility in a Rat Model of Herpes Simplex Type 1 Encephalitis Journal of Neurovirology. Apr, 2008 | Pubmed ID: 18444082 Progress and Prospects in Rat Genetics: a Community View Nature Genetics. May, 2008 | Pubmed ID: 18443588 Increased Prevalence of Multiple Sclerosis Among COPD Patients and Their First-degree Relatives: a Population-based Study Lung. May-Jun, 2008 | Pubmed ID: 18351419 Vra4 Congenic Rats with Allelic Differences in the Class II Transactivator Gene Display Altered Susceptibility to Experimental Autoimmune Encephalomyelitis Journal of Immunology (Baltimore, Md. : 1950). Mar, 2008 | Pubmed ID: 18292553 Genetic Analysis of Neuropathic Pain-like Behavior Following Peripheral Nerve Injury Suggests a Role of the Major Histocompatibility Complex in Development of Allodynia Pain. Jun, 2008 | Pubmed ID: 17764842 Neurofascin As a Novel Target for Autoantibody-mediated Axonal Injury The Journal of Experimental Medicine. Oct, 2007 | Pubmed ID: 17846150 Variation in Interleukin 7 Receptor Alpha Chain (IL7R) Influences Risk of Multiple Sclerosis Nature Genetics. Sep, 2007 | Pubmed ID: 17660816 Temporal Expression and Cellular Origin of CC Chemokine Receptors CCR1, CCR2 and CCR5 in the Central Nervous System: Insight into Mechanisms of MOG-induced EAE Journal of Neuroinflammation. May, 2007 | Pubmed ID: 17484785 Cortical Demyelination Can Be Modeled in Specific Rat Models of Autoimmune Encephalomyelitis and is Major Histocompatibility Complex (MHC) Haplotype-related Journal of Neuropathology and Experimental Neurology. Dec, 2006 | Pubmed ID: 17146287 Combined-cross Analysis of Genome-wide Linkage Scans for Experimental Autoimmune Encephalomyelitis in Rat Genomics. Dec, 2006 | Pubmed ID: 17010567 Genetics of Autoimmune Neuroinflammation Current Opinion in Immunology. Dec, 2006 | Pubmed ID: 16973343 Genetically Determined Susceptibility to Neurodegeneration is Associated with Expression of Inflammatory Genes Neurobiology of Disease. Oct, 2006 | Pubmed ID: 16934480 Nitric Oxide Exposure Diverts Neural Stem Cell Fate from Neurogenesis Towards Astrogliogenesis Stem Cells (Dayton, Ohio). Dec, 2006 | Pubmed ID: 16916924 Intravenous Immunoglobulin for Post-polio Syndrome: a Randomised Controlled Trial The Lancet. Neurology. Jun, 2006 | Pubmed ID: 16713921 [New Era for MS Treatment. Severe Setback when It Comes to Enthusiasm--highly Effective Agent Caused Serious Adverse Effects] Lakartidningen. Apr 26-May 2, 2006 | Pubmed ID: 16708855 Advanced Intercross Line Mapping of Eae5 Reveals Ncf-1 and CLDN4 As Candidate Genes for Experimental Autoimmune Encephalomyelitis Journal of Immunology (Baltimore, Md. : 1950). May, 2006 | Pubmed ID: 16670314 Definition of a 1.06-Mb Region Linked to Neuroinflammation in Humans, Rats and Mice Genetics. Jul, 2006 | Pubmed ID: 16624898 Effect of Intravenous Immunoglobulin in Patients with Post-polio Syndrome -- an Uncontrolled Pilot Study Journal of Rehabilitation Medicine. Mar, 2006 | Pubmed ID: 16546773 Neurogenesis in the Adult Spinal Cord in an Experimental Model of Multiple Sclerosis The European Journal of Neuroscience. Jan, 2006 | Pubmed ID: 16420447 Cytokine Responses During Chronic Denervation Journal of Neuroinflammation. Nov, 2005 | Pubmed ID: 16287511 Effects of Long Term NOS Inhibition on Disease and the Immune System in MOG Induced EAE Nitric Oxide : Biology and Chemistry. Nov, 2005 | Pubmed ID: 16102987 CX3CL1 (fractalkine) and CX3CR1 Expression in Myelin Oligodendrocyte Glycoprotein-induced Experimental Autoimmune Encephalomyelitis: Kinetics and Cellular Origin Journal of Neuroinflammation. Jul, 2005 | Pubmed ID: 16053521 CDR3 Sequence Preference of TCRBV8S2+ T Cells Within the CNS Does Not Reflect Single Amino Acid Dependent Avidity Expansion Journal of Neuroimmunology. Sep, 2005 | Pubmed ID: 15963573 Immunological Patterns Identifying Disease Course and Evolution in Multiple Sclerosis Patients Journal of Neuroimmunology. Aug, 2005 | Pubmed ID: 15949850 Expression of T Cell Immunoglobulin- and Mucin-domain-containing Molecules-1 and -3 (TIM-1 and -3) in the Rat Nervous and Immune Systems Journal of Neuroimmunology. Jul, 2005 | Pubmed ID: 15913792 Genetic Dissection of Neurodegeneration and CNS Inflammation Journal of the Neurological Sciences. Jun, 2005 | Pubmed ID: 15894332 MHC2TA is Associated with Differential MHC Molecule Expression and Susceptibility to Rheumatoid Arthritis, Multiple Sclerosis and Myocardial Infarction Nature Genetics. May, 2005 | Pubmed ID: 15821736 Eae19, a New Locus on Rat Chromosome 15 Regulating Experimental Autoimmune Encephalomyelitis Genetics. May, 2005 | Pubmed ID: 15716504 Resolution of a 16.8-Mb Autoimmunity-regulating Rat Chromosome 4 Region into Multiple Encephalomyelitis Quantitative Trait Loci and Evidence for Epistasis Journal of Immunology (Baltimore, Md. : 1950). Jan, 2005 | Pubmed ID: 15634914 Ro/SSA Autoantibodies Directly Bind Cardiomyocytes, Disturb Calcium Homeostasis, and Mediate Congenital Heart Block The Journal of Experimental Medicine. Jan, 2005 | Pubmed ID: 15630133 Parental Age, Family Size, and Risk of Multiple Sclerosis Epidemiology (Cambridge, Mass.). Nov, 2004 | Pubmed ID: 15475721 MHC and Non-MHC Gene Regulation of Disease Susceptibility and Disease Course in Experimental Inflammatory Peripheral Neuropathy Journal of Neuroimmunology. Oct, 2004 | Pubmed ID: 15342198 Deletion of the Adenosine A1 Receptor Gene Does Not Alter Neuronal Damage Following Ischaemia in Vivo or in Vitro The European Journal of Neuroscience. Sep, 2004 | Pubmed ID: 15341591 MHC Class II Isotype- and Allele-specific Attenuation of Experimental Autoimmune Encephalomyelitis Journal of Immunology (Baltimore, Md. : 1950). Aug, 2004 | Pubmed ID: 15294998 An Advanced Intercross Line Resolves Eae18 into Two Narrow Quantitative Trait Loci Syntenic to Multiple Sclerosis Candidate Loci Journal of Immunology (Baltimore, Md. : 1950). Jul, 2004 | Pubmed ID: 15240732 T Cell Ig- and Mucin-domain-containing Molecule-3 (TIM-3) and TIM-1 Molecules Are Differentially Expressed on Human Th1 and Th2 Cells and in Cerebrospinal Fluid-derived Mononuclear Cells in Multiple Sclerosis Journal of Immunology (Baltimore, Md. : 1950). Jun, 2004 | Pubmed ID: 15153541 Prior Poliomyelitis-IVIg Treatment Reduces Proinflammatory Cytokine Production Journal of Neuroimmunology. May, 2004 | Pubmed ID: 15081258 Immunohistochemical Analysis in the Rat Central Nervous System and Peripheral Lymph Node Tissue Sections Milena Z. Adzemovic1,2, Manuel Zeitelhofer1,3, Marianne Leisser2, Ulricke Köck2, Angela Kury2, Tomas Olsson1 1Department of Clinical Neuroscience, Neuroimmunology Unit, Center for Molecular Medicine, Karolinska Institutet, 2Department of Neuroimmunology, Center for Brain Research, Medical University of Vienna, 3Department of Medical Biochemistry and Biophysics, Vascular Biology Unit, Karolinska Institutet JoVE 50425 Neurosciences
Immunohistochemical Analysis in the Rat Central Nervous System and Peripheral Lymph Node Tissue Sections Milena Z. Adzemovic1,2, Manuel Zeitelhofer1,3, Marianne Leisser2, Ulricke Köck2, Angela Kury2, Tomas Olsson1 1Department of Clinical Neuroscience, Neuroimmunology Unit, Center for Molecular Medicine, Karolinska Institutet, 2Department of Neuroimmunology, Center for Brain Research, Medical University of Vienna, 3Department of Medical Biochemistry and Biophysics, Vascular Biology Unit, Karolinska Institutet JoVE 50425 Neurosciences