Ursula Jakob Department of Molecular, Cellular, and Developmental Biology University of Michigan Biography Publications Institution JoVE Articles Ursula Jakob has not added a biography. If you are Ursula Jakob and would like to personalize this page please email our Author Liaison for assistance. Publications Polyphosphate: A Conserved Modifier of Amyloidogenic Processes Molecular Cell. Sep, 2016 | Pubmed ID: 27570072 Do Nucleic Acids Moonlight As Molecular Chaperones? Nucleic Acids Research. Jun, 2016 | Pubmed ID: 27105849 Protein Unfolding As a Switch from Self-recognition to High-affinity Client Binding Nature Communications. Jan, 2016 | Pubmed ID: 26787517 Janus-faced Sestrin2 Controls ROS and MTOR Signalling Through Two Separate Functional Domains Nature Communications. Nov, 2015 | Pubmed ID: 26612684 HdeB Functions As an Acid-protective Chaperone in Bacteria The Journal of Biological Chemistry. Apr, 2015 | Pubmed ID: 25888567 Does the Transcription Factor NemR Use a Regulatory Sulfenamide Bond to Sense Bleach? Antioxidants & Redox Signaling. Sep, 2015 | Pubmed ID: 25867078 Protein Quality Control Under Oxidative Stress Conditions Journal of Molecular Biology. Apr, 2015 | Pubmed ID: 25698115 Mitochondrial Peroxiredoxin Functions As Crucial Chaperone Reservoir in Leishmania Infantum Proceedings of the National Academy of Sciences of the United States of America. Feb, 2015 | Pubmed ID: 25646478 Oxidative Stress Protection by Polyphosphate--new Roles for an Old Player Current Opinion in Microbiology. Apr, 2015 | Pubmed ID: 25589044 HdeB Functions As an Acid-protective Chaperone in Bacteria The Journal of Biological Chemistry. Jan, 2015 | Pubmed ID: 25391835 The 'mitoflash' Probe CpYFP Does Not Respond to Superoxide Nature. Oct, 2014 | Pubmed ID: 25341790 The Protein Targeting Factor Get3 Functions As ATP-independent Chaperone Under Oxidative Stress Conditions Molecular Cell. Oct, 2014 | Pubmed ID: 25242142 About the Dangers, Costs and Benefits of Living an Aerobic Lifestyle Biochemical Society Transactions. Aug, 2014 | Pubmed ID: 25109979 Bile Salts Act As Effective Protein-unfolding Agents and Instigators of Disulfide Stress in Vivo Proceedings of the National Academy of Sciences of the United States of America. Apr, 2014 | Pubmed ID: 24706920 Thiol-based Redox Switches Biochimica Et Biophysica Acta. Aug, 2014 | Pubmed ID: 24657586 Polyphosphate is a Primordial Chaperone Molecular Cell. Mar, 2014 | Pubmed ID: 24560923 Conditionally and Transiently Disordered Proteins: Awakening Cryptic Disorder to Regulate Protein Function Chemical Reviews. Jul, 2014 | Pubmed ID: 24502763 The RclR Protein is a Reactive Chlorine-specific Transcription Factor in Escherichia Coli The Journal of Biological Chemistry. Nov, 2013 | Pubmed ID: 24078635 Oxidant Sensing by Reversible Disulfide Bond Formation The Journal of Biological Chemistry. Sep, 2013 | Pubmed ID: 23861395 Bacterial Responses to Reactive Chlorine Species Annual Review of Microbiology. 2013 | Pubmed ID: 23768204 Nonnative Disulfide Bond Formation Activates the σ32-dependent Heat Shock Response in Escherichia Coli Journal of Bacteriology. Jun, 2013 | Pubmed ID: 23585533 NemR is a Bleach-sensing Transcription Factor The Journal of Biological Chemistry. May, 2013 | Pubmed ID: 23536188 The Roles of Conditional Disorder in Redox Proteins Current Opinion in Structural Biology. Jun, 2013 | Pubmed ID: 23477949 Time Line of Redox Events in Aging Postmitotic Cells ELife. Feb, 2013 | Pubmed ID: 23390587 Redox Control: A Black Hole for Oxidized Glutathione Nature Chemical Biology. Feb, 2013 | Pubmed ID: 23334544 Get3 is a Holdase Chaperone and Moves to Deposition Sites for Aggregated Proteins when Membrane Targeting is Blocked Journal of Cell Science. Jan, 2013 | Pubmed ID: 23203805 Conditional Disorder in Chaperone Action Trends in Biochemical Sciences. Dec, 2012 | Pubmed ID: 23018052 Quantitative in Vivo Redox Sensors Uncover Oxidative Stress As an Early Event in Life Molecular Cell. Sep, 2012 | Pubmed ID: 22819323 Redox, Haem and CO in Enzymatic Catalysis and Regulation Biochemical Society Transactions. Jun, 2012 | Pubmed ID: 22616859 Order out of Disorder: Working Cycle of an Intrinsically Unfolded Chaperone Cell. Mar, 2012 | Pubmed ID: 22385960 Hsp33 Confers Bleach Resistance by Protecting Elongation Factor Tu Against Oxidative Degradation in Vibrio Cholerae Molecular Microbiology. Mar, 2012 | Pubmed ID: 22296329 E. Coli Chaperones DnaK, Hsp33 and Spy Inhibit Bacterial Functional Amyloid Assembly Prion. Oct-Dec, 2011 | Pubmed ID: 22156728 Using Quantitative Redox Proteomics to Dissect the Yeast Redoxome The Journal of Biological Chemistry. Dec, 2011 | Pubmed ID: 21976664 Genetic Selection Designed to Stabilize Proteins Uncovers a Chaperone Called Spy Nature Structural & Molecular Biology. Mar, 2011 | Pubmed ID: 21317898 Chlorinated Phenols Control the Expression of the Multidrug Resistance Efflux Pump MexAB-OprM in Pseudomonas Aeruginosa by Interacting with NalC Molecular Microbiology. Mar, 2011 | Pubmed ID: 21231970 The Redoxome: Proteomic Analysis of Cellular Redox Networks Current Opinion in Chemical Biology. Feb, 2011 | Pubmed ID: 21130023 Are Zinc-finger Domains of Protein Kinase C Dynamic Structures That Unfold by Lipid or Redox Activation? Antioxidants & Redox Signaling. Mar, 2011 | Pubmed ID: 21067413 Is Overoxidation of Peroxiredoxin Physiologically Significant? Antioxidants & Redox Signaling. Feb, 2011 | Pubmed ID: 20964547 Effects of Oxidative Stress on Behavior, Physiology, and the Redox Thiol Proteome of Caenorhabditis Elegans Antioxidants & Redox Signaling. Mar, 2011 | Pubmed ID: 20649472 Unfolding of Metastable Linker Region is at the Core of Hsp33 Activation As a Redox-regulated Chaperone The Journal of Biological Chemistry. Apr, 2010 | Pubmed ID: 20139072 Protein Refolding by PH-triggered Chaperone Binding and Release Proceedings of the National Academy of Sciences of the United States of America. Jan, 2010 | Pubmed ID: 20080625 Thermodynamic Analysis of a Molecular Chaperone Binding to Unfolded Protein Substrates Biochemistry. Feb, 2010 | Pubmed ID: 20073505 Heme Regulatory Motifs in Heme Oxygenase-2 Form a Thiol/disulfide Redox Switch That Responds to the Cellular Redox State The Journal of Biological Chemistry. Jul, 2009 | Pubmed ID: 19473966 Interplay of Cellular CAMP Levels, {sigma}S Activity and Oxidative Stress Resistance in Escherichia Coli Microbiology (Reading, England). May, 2009 | Pubmed ID: 19372151 Redox-regulated Chaperones Biochemistry. Jun, 2009 | Pubmed ID: 19368357 Structural Plasticity of an Acid-activated Chaperone Allows Promiscuous Substrate Binding Proceedings of the National Academy of Sciences of the United States of America. Apr, 2009 | Pubmed ID: 19321422 Thiol-based Redox Switches in Eukaryotic Proteins Antioxidants & Redox Signaling. May, 2009 | Pubmed ID: 18999917 Special Issue: Redox Regulation of Protein Folding. Preface Biochimica Et Biophysica Acta. Apr, 2008 | Pubmed ID: 18395585 Quantifying Changes in the Thiol Redox Proteome Upon Oxidative Stress in Vivo Proceedings of the National Academy of Sciences of the United States of America. Jun, 2008 | Pubmed ID: 18287020 Nitrosative Stress Treatment of E. Coli Targets Distinct Set of Thiol-containing Proteins Molecular Microbiology. Nov, 2007 | Pubmed ID: 17919278 The Redox-switch Domain of Hsp33 Functions As Dual Stress Sensor Nature Structural & Molecular Biology. Jun, 2007 | Pubmed ID: 17515905 Zinc Center As Redox Switch--new Function for an Old Motif Antioxidants & Redox Signaling. May-Jun, 2006 | Pubmed ID: 16771674 Global Methods to Monitor the Thiol-disulfide State of Proteins in Vivo Antioxidants & Redox Signaling. May-Jun, 2006 | Pubmed ID: 16771668 XIAP Is a Copper Binding Protein Deregulated in Wilson's Disease and Other Copper Toxicosis Disorders Molecular Cell. Mar, 2006 | Pubmed ID: 16543147 CoSMoS: Conserved Sequence Motif Search in the Proteome BMC Bioinformatics. Jan, 2006 | Pubmed ID: 16433915 Transarterial Chemoembolization in the Treatment of Hepatoblastoma in Children European Radiology. Jun, 2006 | Pubmed ID: 16003511 Severe Oxidative Stress Causes Inactivation of DnaK and Activation of the Redox-regulated Chaperone Hsp33 Molecular Cell. Feb, 2005 | Pubmed ID: 15694339 Beyond Transcription--new Mechanisms for the Regulation of Molecular Chaperones Critical Reviews in Biochemistry and Molecular Biology. Sep-Dec, 2004 | Pubmed ID: 15763707 Protein Thiol Modifications Visualized in Vivo PLoS Biology. Nov, 2004 | Pubmed ID: 15502869 The Crystal Structure of the Reduced, Zn2+-bound Form of the B. Subtilis Hsp33 Chaperone and Its Implications for the Activation Mechanism Structure (London, England : 1993). Oct, 2004 | Pubmed ID: 15458638 Substrate Binding Analysis of the 23S RRNA Methyltransferase RrmJ Journal of Bacteriology. Oct, 2004 | Pubmed ID: 15375145 The Zinc-dependent Redox Switch Domain of the Chaperone Hsp33 Has a Novel Fold Journal of Molecular Biology. Aug, 2004 | Pubmed ID: 15328602 Activation of the Redox-regulated Chaperone Hsp33 by Domain Unfolding The Journal of Biological Chemistry. May, 2004 | Pubmed ID: 15023991 Identification of a Redox-regulated Chaperone Network The EMBO Journal. Jan, 2004 | Pubmed ID: 14685279 Not Every Disulfide Lasts Forever: Disulfide Bond Formation As a Redox Switch Antioxidants & Redox Signaling. Aug, 2003 | Pubmed ID: 13678530 Thioredoxin 2, an Oxidative Stress-induced Protein, Contains a High Affinity Zinc Binding Site The Journal of Biological Chemistry. Nov, 2003 | Pubmed ID: 12952960 The Roles of the Two Zinc Binding Sites in DnaJ The Journal of Biological Chemistry. Nov, 2003 | Pubmed ID: 12941935 Active Site in RrmJ, a Heat Shock-induced Methyltransferase The Journal of Biological Chemistry. Nov, 2002 | Pubmed ID: 12181314 Overexpression of Two Different GTPases Rescues a Null Mutation in a Heat-induced RRNA Methyltransferase Journal of Bacteriology. May, 2002 | Pubmed ID: 11976298 Detection of the pH-dependent Activity of Escherichia coli Chaperone HdeB In Vitro and In Vivo Jan-Ulrik Dahl1, Philipp Koldewey1,2, James C. A. Bardwell1,2, Ursula Jakob1 1Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 2Howard Hughes Medical Institute, University of Michigan JoVE 54527 Biochimie
Detection of the pH-dependent Activity of Escherichia coli Chaperone HdeB In Vitro and In Vivo Jan-Ulrik Dahl1, Philipp Koldewey1,2, James C. A. Bardwell1,2, Ursula Jakob1 1Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 2Howard Hughes Medical Institute, University of Michigan JoVE 54527 Biochimie