Volker Brinkmann Microscopy Core Facility Max Planck Institute for Infection Biology Biography Publications Institution JoVE Articles Volker BrinkmannStaff scientist The publication list contains numerous papers from a scientist with the same name. Publications The Exported Plasmodium Berghei Protein IBIS1 Delineates Membranous Structures in Infected Red Blood Cells Molecular Microbiology. Feb, 2012 | Pubmed ID: 22329949 Critical Role for Heat Shock Protein 20 (HSP20) in Migration of Malarial Sporozoites The Journal of Biological Chemistry. Jan, 2012 | Pubmed ID: 22139844 Therapeutic Dosing of Fingolimod (FTY720) Prevents Cell Infiltration, Rapidly Suppresses Ocular Inflammation, and Maintains the Blood-ocular Barrier The American Journal of Pathology. Feb, 2012 | Pubmed ID: 22119714 Optimal Deconvolution of Transcriptional Profiling Data Using Quadratic Programming with Application to Complex Clinical Blood Samples PloS One. Month, 2011 | Pubmed ID: 22110609 A Mechanistically Novel, First Oral Therapy for Multiple Sclerosis: the Development of Fingolimod (FTY720, Gilenya) Discovery Medicine. Sep, 2011 | Pubmed ID: 21955849 Autophagy-independent Function of MAP-LC3 During Intracellular Propagation of Chlamydia Trachomatis Autophagy. Aug, 2011 | Pubmed ID: 21464618 Sphingosine 1-phosphate (S1P): Physiology and the Effects of S1P Receptor Modulation Neurology. Feb, 2011 | Pubmed ID: 21339489 Impact of Sphingosine 1-phosphate Modulation on Immune Outcomes Neurology. Feb, 2011 | Pubmed ID: 21339486 Fingolimod Provides Long-term Protection in Rodent Models of Cerebral Ischemia Annals of Neurology. Jan, 2011 | Pubmed ID: 21280082 Prevalence of Propionibacterium Acnes in Diseased Prostates and Its Inflammatory and Transforming Activity on Prostate Epithelial Cells International Journal of Medical Microbiology : IJMM. Jan, 2011 | Pubmed ID: 20943438 Angiogenesis is Present in Experimental Autoimmune Encephalomyelitis and Pro-angiogenic Factors Are Increased in Multiple Sclerosis Lesions Journal of Neuroinflammation. Month, 2010 | Pubmed ID: 21176212 Helicobacter Pylori HP0518 Affects Flagellin Glycosylation to Alter Bacterial Motility Molecular Microbiology. Dec, 2010 | Pubmed ID: 21091500 Fingolimod Provides Long-term Protection in Rodent Models of Cerebral Ischemia Annals of Neurology. Nov, 2010 | Pubmed ID: 21077181 Fingolimod (FTY720): Discovery and Development of an Oral Drug to Treat Multiple Sclerosis Nature Reviews. Drug Discovery. Nov, 2010 | Pubmed ID: 21031003 Tyrosine-phosphorylated Caveolin-1 Blocks Bacterial Uptake by Inducing Vav2-RhoA-mediated Cytoskeletal Rearrangements PLoS Biology. Month, 2010 | Pubmed ID: 20808760 Reciprocal Coupling of Coagulation and Innate Immunity Via Neutrophil Serine Proteases Nature Medicine. Aug, 2010 | Pubmed ID: 20676107 A Key Role for Lung-resident Memory Lymphocytes in Protective Immune Responses After BCG Vaccination European Journal of Immunology. Sep, 2010 | Pubmed ID: 20602436 Impairment of Neutrophil Extracellular Trap Degradation is Associated with Lupus Nephritis Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20439745 The Adaptor Molecule CARD9 is Essential for Tuberculosis Control The Journal of Experimental Medicine. Apr, 2010 | Pubmed ID: 20351059 Alpha-GalCer Ameliorates Listeriosis by Accelerating Infiltration of Gr-1+ Cells into the Liver European Journal of Immunology. May, 2010 | Pubmed ID: 20162550 Dynamic T Cell Migration Program Provides Resident Memory Within Intestinal Epithelium The Journal of Experimental Medicine. Mar, 2010 | Pubmed ID: 20156972 Mouse Neutrophil Extracellular Traps in Microbial Infections Journal of Innate Immunity. Month, 2009 | Pubmed ID: 20375576 Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense Against Candida Albicans PLoS Pathogens. Oct, 2009 | Pubmed ID: 19876394 Bacterial Porin Disrupts Mitochondrial Membrane Potential and Sensitizes Host Cells to Apoptosis PLoS Pathogens. Oct, 2009 | Pubmed ID: 19851451 Rab6 and Rab11 Regulate Chlamydia Trachomatis Development and Golgin-84-dependent Golgi Fragmentation PLoS Pathogens. Oct, 2009 | Pubmed ID: 19816566 FTY720 (fingolimod) in Multiple Sclerosis: Therapeutic Effects in the Immune and the Central Nervous System British Journal of Pharmacology. Nov, 2009 | Pubmed ID: 19814729 Restoration of NET Formation by Gene Therapy in CGD Controls Aspergillosis Blood. Sep, 2009 | Pubmed ID: 19541821 The Potent Protein Kinase C-selective Inhibitor AEB071 (sotrastaurin) Represents a New Class of Immunosuppressive Agents Affecting Early T-cell Activation The Journal of Pharmacology and Experimental Therapeutics. Sep, 2009 | Pubmed ID: 19491325 Netting Neutrophils in Autoimmune Small-vessel Vasculitis Nature Medicine. Jun, 2009 | Pubmed ID: 19448636 Identifying Activated T Cells in Reconstituted RAG Deficient Mice Using Retrovirally Transduced Pax5 Deficient Pro-B Cells PloS One. Month, 2009 | Pubmed ID: 19340306 Bim and Bmf Synergize to Induce Apoptosis in Neisseria Gonorrhoeae Infection PLoS Pathogens. Mar, 2009 | Pubmed ID: 19300516 Chlamydia Causes Fragmentation of the Golgi Compartment to Ensure Reproduction Nature. Feb, 2009 | Pubmed ID: 19060882 Real-time Imaging of Leishmania Mexicana-infected Early Phagosomes: a Study Using Primary Macrophages Generated from Green Fluorescent Protein-Rab5 Transgenic Mice FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2009 | Pubmed ID: 18927250 Sphingosine 1-phosphate Receptor Agonism Impairs Skin Dendritic Cell Migration and Homing to Secondary Lymphoid Tissue: Association with Prolonged Allograft Survival Transplant Immunology. Nov, 2008 | Pubmed ID: 18694829 Infection at the Cellular Level Methods in Cell Biology. Month, 2008 | Pubmed ID: 18617048 Transgenic, Fluorescent Leishmania Mexicana Allow Direct Analysis of the Proteome of Intracellular Amastigotes Molecular & Cellular Proteomics : MCP. Sep, 2008 | Pubmed ID: 18474515 Anticancer Activity of FTY720: Phosphorylated FTY720 Inhibits Autotaxin, a Metastasis-enhancing and Angiogenic Lysophospholipase D Cancer Letters. Aug, 2008 | Pubmed ID: 18378389 Delay of Phagosome Maturation by a Mycobacterial Lipid is Reversed by Nitric Oxide Cellular Microbiology. Jul, 2008 | Pubmed ID: 18363878 Modulation of T Cell Homeostasis and Alloreactivity Under Continuous FTY720 Exposure International Immunology. May, 2008 | Pubmed ID: 18343890 Role of Interleukin-12 in Determining Differential Kinetics of Invariant Natural Killer T Cells in Response to Differential Burden of Listeria Monocytogenes Microbes and Infection / Institut Pasteur. Mar, 2008 | Pubmed ID: 18321748 Long-term Effects of Natural Amino Acids on Infection with Chlamydia Trachomatis Microbial Pathogenesis. May, 2008 | Pubmed ID: 18222624 Requirement of Secondary Lymphoid Tissues for the Induction of Primary and Secondary T Cell Responses Against Listeria Monocytogenes European Journal of Immunology. Jan, 2008 | Pubmed ID: 18050270 A Small Non-coding RNA of the Invasion Gene Island (SPI-1) Represses Outer Membrane Protein Synthesis from the Salmonella Core Genome Molecular Microbiology. Dec, 2007 | Pubmed ID: 17971080 Beneficial Suicide: Why Neutrophils Die to Make NETs Nature Reviews. Microbiology. Aug, 2007 | Pubmed ID: 17632569 Insights into the Mechanism of FTY720 and Compatibility with Regulatory T Cells for the Inhibition of Graft-versus-host Disease (GVHD) Blood. Nov, 2007 | Pubmed ID: 17606761 Sphingosine 1-phosphate Receptors in Health and Disease: Mechanistic Insights from Gene Deletion Studies and Reverse Pharmacology Pharmacology & Therapeutics. Jul, 2007 | Pubmed ID: 17561264 FTY720, an Immunomodulatory Sphingolipid Mimetic: Translation of a Novel Mechanism into Clinical Benefit in Multiple Sclerosis Expert Opinion on Investigational Drugs. Mar, 2007 | Pubmed ID: 17302523 FTY720, a Synthetic Sphingosine 1 Phosphate Analogue, Inhibits Development of Atherosclerosis in Low-density Lipoprotein Receptor-deficient Mice Circulation. Jan, 2007 | Pubmed ID: 17242282 The Helicobacter Pylori CagA Protein Disrupts Matrix Adhesion of Gastric Epithelial Cells by Dephosphorylation of Vinculin Cellular Microbiology. May, 2007 | Pubmed ID: 17217431 Novel Cell Death Program Leads to Neutrophil Extracellular Traps The Journal of Cell Biology. Jan, 2007 | Pubmed ID: 17210947 Sphingosine-1-phosphate Stimulates the Functional Capacity of Progenitor Cells by Activation of the CXCR4-dependent Signaling Pathway Via the S1P3 Receptor Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2007 | Pubmed ID: 17158356 Critical Role of Methylglyoxal and AGE in Mycobacteria-induced Macrophage Apoptosis and Activation PloS One. Month, 2006 | Pubmed ID: 17183656 FTY720 Preferentially Depletes Naive T Cells from Peripheral and Lymphoid Organs International Immunopharmacology. Dec, 2006 | Pubmed ID: 17161343 A Monoselective Sphingosine-1-phosphate Receptor-1 Agonist Prevents Allograft Rejection in a Stringent Rat Heart Transplantation Model Chemistry & Biology. Nov, 2006 | Pubmed ID: 17114004 Naturally Occurring Amino Acids Differentially Influence the Development of Chlamydia Trachomatis and Chlamydia (Chlamydophila) Pneumoniae Journal of Medical Microbiology. Jul, 2006 | Pubmed ID: 16772415 Pulmonary and Vascular Pharmacology of Sphingosine 1-phosphate Current Opinion in Pharmacology. Jun, 2006 | Pubmed ID: 16563863 Neutrophil Extracellular Traps Capture and Kill Candida Albicans Yeast and Hyphal Forms Cellular Microbiology. Apr, 2006 | Pubmed ID: 16548892 Apoptotic Vesicles Crossprime CD8 T Cells and Protect Against Tuberculosis Immunity. Jan, 2006 | Pubmed ID: 16413927 A Novel Low Molecular Weight Inhibitor of Dendritic Cells and B Cells Blocks Allergic Inflammation American Journal of Respiratory and Critical Care Medicine. Mar, 2006 | Pubmed ID: 16387807 Novel Insights into the Mechanism of Action of FTY720 in a Transgenic Model of Allograft Rejection: Implications for Therapy of Chronic Rejection Journal of Immunology (Baltimore, Md. : 1950). Jan, 2006 | Pubmed ID: 16365393 The Sphingosine 1-phosphate Receptor Agonist FTY720 Differentially Affects the Sequestration of CD4+/CD25+ T-regulatory Cells and Enhances Their Functional Activity Journal of Immunology (Baltimore, Md. : 1950). Dec, 2005 | Pubmed ID: 16339533 Human Neutrophils Kill Bacillus Anthracis PLoS Pathogens. Nov, 2005 | Pubmed ID: 16292357 Transient T Cell Accumulation in Lymph Nodes and Sustained Lymphopenia in Mice Treated with FTY720 European Journal of Immunology. Dec, 2005 | Pubmed ID: 16285007 The Sphingosine-1-phosphate Receptor Agonist FTY720 Modulates Dendritic Cell Trafficking in Vivo American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Nov, 2005 | Pubmed ID: 16212624 Increased Vaccine Efficacy Against Tuberculosis of Recombinant Mycobacterium Bovis Bacille Calmette-Guérin Mutants That Secrete Listeriolysin The Journal of Clinical Investigation. Sep, 2005 | Pubmed ID: 16110326 FTY720 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Drug Resistance Cancer Research. Aug, 2005 | Pubmed ID: 16103102 Novel Immunomodulator FTY720 is Phosphorylated in Rats and Humans to Form a Single Stereoisomer. Identification, Chemical Proof, and Biological Characterization of the Biologically Active Species and Its Enantiomer Journal of Medicinal Chemistry. Aug, 2005 | Pubmed ID: 16078855 Prohibitin is Required for Ras-induced Raf-MEK-ERK Activation and Epithelial Cell Migration Nature Cell Biology. Aug, 2005 | Pubmed ID: 16041367 Protection of Mouse Small Bowel Allografts by FTY720 and Costimulation Blockade Transplantation. Jun, 2005 | Pubmed ID: 15973172 Immunomodulator FTY720 Induces ENOS-dependent Arterial Vasodilatation Via the Lysophospholipid Receptor S1P3 Circulation Research. Apr, 2005 | Pubmed ID: 15802614 Modified Immunohistological Staining Allows Detection of Ziehl-Neelsen-negative Mycobacterium Tuberculosis Organisms and Their Precise Localization in Human Tissue The Journal of Pathology. Apr, 2005 | Pubmed ID: 15776475 The Heart Rate Decrease Caused by Acute FTY720 Administration is Mediated by the G Protein-gated Potassium Channel I American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Mar, 2005 | Pubmed ID: 15707407 FTY720: Mechanism of Action and Potential Benefit in Organ Transplantation Yonsei Medical Journal. Dec, 2004 | Pubmed ID: 15627289 Lack of Stage-specific Proteins in Coccoid Helicobacter Pylori Cells Infection and Immunity. Nov, 2004 | Pubmed ID: 15501814 Interaction of Chlamydia Trachomatis Serovar L2 with the Host Autophagic Pathway Infection and Immunity. Aug, 2004 | Pubmed ID: 15271937 FTY720: Sphingosine 1-phosphate Receptor-1 in the Control of Lymphocyte Egress and Endothelial Barrier Function American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Jul, 2004 | Pubmed ID: 15196057 Helicobacter Pylori Induces AGS Cell Motility and Elongation Via Independent Signaling Pathways Infection and Immunity. Jun, 2004 | Pubmed ID: 15155677 Calcium and a Calcium-dependent Protein Kinase Regulate Gamete Formation and Mosquito Transmission in a Malaria Parasite Cell. May, 2004 | Pubmed ID: 15137943 Efficacy and Safety of ABI793, a Novel Human Anti-human CD154 Monoclonal Antibody, in Cynomolgus Monkey Renal Allotransplantation Transplantation. Mar, 2004 | Pubmed ID: 15021835 Neutrophil Extracellular Traps Kill Bacteria Science (New York, N.Y.). Mar, 2004 | Pubmed ID: 15001782 The Sphingosine 1-phosphate Receptor Agonist FTY720 Supports CXCR4-dependent Migration and Bone Marrow Homing of Human CD34+ Progenitor Cells Blood. Jun, 2004 | Pubmed ID: 14988150 From the Inside Out--processing of the Chlamydial Autotransporter PmpD and Its Role in Bacterial Adhesion and Activation of Human Host Cells Molecular Microbiology. Jan, 2004 | Pubmed ID: 14756775 Lymphocyte Egress from Thymus and Peripheral Lymphoid Organs is Dependent on S1P Receptor 1 Nature. Jan, 2004 | Pubmed ID: 14737169 Saposin C is Required for Lipid Presentation by Human CD1b Nature Immunology. Feb, 2004 | Pubmed ID: 14716313 Inhibition of Th1- and Th2-mediated Airway Inflammation by the Sphingosine 1-phosphate Receptor Agonist FTY720 Journal of Immunology (Baltimore, Md. : 1950). Dec, 2003 | Pubmed ID: 14634137 Highly Biased Type 1 Immune Responses in Mice Deficient in LFA-1 in Listeria Monocytogenes Infection Are Caused by Elevated IL-12 Production by Granulocytes Journal of Immunology (Baltimore, Md. : 1950). Oct, 2003 | Pubmed ID: 14530315 Phosphorylation and Action of the Immunomodulator FTY720 Inhibits Vascular Endothelial Cell Growth Factor-induced Vascular Permeability The Journal of Biological Chemistry. Nov, 2003 | Pubmed ID: 12954648 Apoptosis Facilitates Antigen Presentation to T Lymphocytes Through MHC-I and CD1 in Tuberculosis Nature Medicine. Aug, 2003 | Pubmed ID: 12872166 Increased Resistance of LFA-1-deficient Mice to Lipopolysaccharide-induced Shock/liver Injury in the Presence of TNF-alpha and IL-12 is Mediated by IL-10: a Novel Role for LFA-1 in the Regulation of the Proinflammatory and Anti-inflammatory Cytokine Balance Journal of Immunology (Baltimore, Md. : 1950). Jul, 2003 | Pubmed ID: 12847222 The Immune Modulator FYT720 Prevents Autoimmune Diabetes in Nonobese Diabetic Mice Small Star, Filled Clinical Immunology (Orlando, Fla.). Apr, 2003 | Pubmed ID: 12738247 Neutrophilia in LFA-1-deficient Mice Confers Resistance to Listeriosis: Possible Contribution of Granulocyte-colony-stimulating Factor and IL-17 Journal of Immunology (Baltimore, Md. : 1950). May, 2003 | Pubmed ID: 12734371 Expression and Translocation of Chlamydial Protease During Acute and Persistent Infection of the Epithelial HEp-2 Cells with Chlamydophila (Chlamydia) Pneumoniae Cellular Microbiology. May, 2003 | Pubmed ID: 12713490 Oral Efficacy of the New Immunomodulator FTY720 in Cynomolgus Monkey Kidney Allotransplantation, Given Alone or in Combination with Cyclosporine or RAD Transplantation. Oct, 2002 | Pubmed ID: 12394836 FTY720 Pretreatment Reduces Warm Hepatic Ischemia Reperfusion Injury Through Inhibition of T-lymphocyte Infiltration American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Oct, 2002 | Pubmed ID: 12392290 Argyrins, Immunosuppressive Cyclic Peptides from Myxobacteria. I. Production, Isolation, Physico-chemical and Biological Properties The Journal of Antibiotics. Jun, 2002 | Pubmed ID: 12195959 FTY720: Targeting G-protein-coupled Receptors for Sphingosine 1-phosphate in Transplantation and Autoimmunity Current Opinion in Immunology. Oct, 2002 | Pubmed ID: 12183155 T-cell Depletion and Graft Survival Induced by Anti-human CD3 Immunotoxins in Human CD3epsilon Transgenic Mice Transplantation. May, 2002 | Pubmed ID: 12042656 Long-term Islet Graft Survival in Streptozotocin- and Autoimmune-induced Diabetes Models by Immunosuppressive and Potential Insulinotropic Agent FTY720 Transplantation. May, 2002 | Pubmed ID: 12023620 The Immune Modulator FTY720 Targets Sphingosine 1-phosphate Receptors The Journal of Biological Chemistry. Jun, 2002 | Pubmed ID: 11967257 The IFN-inducible Golgi- and Endoplasmic Reticulum- Associated 47-kDa GTPase IIGP is Transiently Expressed During Listeriosis Journal of Immunology (Baltimore, Md. : 1950). Apr, 2002 | Pubmed ID: 11907101 Distinct Mechanisms of Internalization of Neisseria Gonorrhoeae by Members of the CEACAM Receptor Family Involving Rac1- and Cdc42-dependent and -independent Pathways The EMBO Journal. Feb, 2002 | Pubmed ID: 11847104 Neisserial Immunoglobulin A1 Protease Induces Specific T-cell Responses in Humans Infection and Immunity. Jan, 2002 | Pubmed ID: 11748199 Immunofluorescenza Etichettatura delle trappole extracellulari di neutrofilo umano e murino nel tessuto incorporato di paraffina Ulrike Abu Abed1,2, Volker Brinkmann1 1Microscopy Core Facility, Max Planck Institute for Infection Biology, 2Cellular Microbiology, Max Planck Institute for Infection Biology JoVE 60115 Médecine Neutrofili Trappole extracellulare: Come generare e poterle visualizzare Volker Brinkmann1, Britta Laube1, Ulrike Abu Abed1,2, Christian Goosmann1,2, Arturo Zychlinsky2 1Core Facility Microscopy, Max Planck Institute for Infection Biology, 2Cellular Microbiology, Max Planck Institute for Infection Biology JoVE 1724 Immunologie et Infection
Immunofluorescenza Etichettatura delle trappole extracellulari di neutrofilo umano e murino nel tessuto incorporato di paraffina Ulrike Abu Abed1,2, Volker Brinkmann1 1Microscopy Core Facility, Max Planck Institute for Infection Biology, 2Cellular Microbiology, Max Planck Institute for Infection Biology JoVE 60115 Médecine
Neutrofili Trappole extracellulare: Come generare e poterle visualizzare Volker Brinkmann1, Britta Laube1, Ulrike Abu Abed1,2, Christian Goosmann1,2, Arturo Zychlinsky2 1Core Facility Microscopy, Max Planck Institute for Infection Biology, 2Cellular Microbiology, Max Planck Institute for Infection Biology JoVE 1724 Immunologie et Infection