Wolfram-Hubertus Zimmermann Institute of Pharmacology and Toxicology University Medical Center Goettingen Biography Publications Institution JoVE Articles Wolfram-Hubertus Zimmermann has not added a biography. If you are Wolfram-Hubertus Zimmermann and would like to personalize this page please email our Author Liaison for assistance. Publications Establishment of Two Homozygous CRISPR Interference (CRISPRi) Knock-in Human Induced Pluripotent Stem Cell (hiPSC) Lines for Titratable Endogenous Gene Repression Stem Cell Research. Jul, 2021 | Pubmed ID: 34343828 Engineered Heart Muscle Models in Phenotypic Drug Screens Handbook of Experimental Pharmacology. 2021 | Pubmed ID: 33136187 Editorial Commentary: Challenges to Heart Repair with Pluripotent Stem Cell-derived Cardiomyocytes Trends in Cardiovascular Medicine. 02, 2021 | Pubmed ID: 32276084 Generation of Homozygous CRISPRa Human Induced Pluripotent Stem Cell (hiPSC) Lines for Sustained Endogenous Gene Activation Stem Cell Research. 10, 2020 | Pubmed ID: 33038615 Developmental GABA Polarity Switch and Neuronal Plasticity in Bioengineered Neuronal Organoids Nature Communications. 07, 2020 | Pubmed ID: 32728089 KLF15-Wnt-Dependent Cardiac Reprogramming Up-Regulates SHISA3 in the Mammalian Heart Journal of the American College of Cardiology. 10, 2019 | Pubmed ID: 31582141 Physics Meets Medicine - At the Heart of Active Matter Progress in Biophysics and Molecular Biology. 07, 2019 | Pubmed ID: 30980833 Cardiac Macrotissues-on-a-plate Models for Phenotypic Drug Screens Advanced Drug Delivery Reviews. 02, 2019 | Pubmed ID: 30902615 Agonistic and Antagonistic Roles of Fibroblasts and Cardiomyocytes on Viscoelastic Stiffening of Engineered Human Myocardium Progress in Biophysics and Molecular Biology. 07, 2019 | Pubmed ID: 30553553 A Scale Model of the Human Ventricle Nature Biomedical Engineering. 12, 2018 | Pubmed ID: 31015732 Engineered Nanoparticles Prevent Dilation of Abdominal Aortic Aneurysms Journal of the American College of Cardiology. 11, 2018 | Pubmed ID: 30466518 Highlighting the Field of Cardiovascular Regenerative Medicine Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2018 | Pubmed ID: 29934254 Comparison of Non-human Primate Versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction Stem Cell Reports. 02, 2018 | Pubmed ID: 29398480 Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery Annual Review of Pharmacology and Toxicology. 01, 2018 | Pubmed ID: 29029591 Generation of a KLF15 Homozygous Knockout Human Embryonic Stem Cell Line Using Paired CRISPR/Cas9n, and Human Cardiomyocytes Derivation Stem Cell Research. 08, 2017 | Pubmed ID: 28925362 Myocardial Tissue Engineering for Regenerative Applications Current Cardiology Reports. 09, 2017 | Pubmed ID: 28752277 Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair Circulation. May, 2017 | Pubmed ID: 28167635 Translating Myocardial Remuscularization Circulation Research. 01, 2017 | Pubmed ID: 28104769 Strip and Dress the Human Heart Circulation Research. Jan, 2016 | Pubmed ID: 26837739 Mechanical Stimulation in the Engineering of Heart Muscle Advanced Drug Delivery Reviews. Jan, 2016 | Pubmed ID: 26362920 New Biologics for the Modulation of Post-Infarct Remodeling: Matricryptins Journal of the American College of Cardiology. Sep, 2015 | Pubmed ID: 26383725 Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model Circulation Research. Sep, 2015 | Pubmed ID: 26291556 Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator Circulation Research. Aug, 2015 | Pubmed ID: 26078285 Physiologic Force-frequency Response in Engineered Heart Muscle by Electromechanical Stimulation Biomaterials. Aug, 2015 | Pubmed ID: 25985155 [Individualized Stem Cell Therapy] Herz. Mar, 2014 | Pubmed ID: 24589843 Modeling Myocardial Growth and Hypertrophy in Engineered Heart Muscle Trends in Cardiovascular Medicine. Jan, 2014 | Pubmed ID: 23953977 Common MicroRNA Signatures in Cardiac Hypertrophic and Atrophic Remodeling Induced by Changes in Hemodynamic Load PloS One. 2010 | Pubmed ID: 21151612 Cardiac Tissue Engineering: Implications for Pediatric Heart Surgery Pediatric Cardiology. Jul, 2009 | Pubmed ID: 19319461 Fibroblast Derived Human Engineered Connective Tissue for Screening Applications Gabriela L. Santos1,2, Tim Meyer1,2, Malte Tiburcy1,2, Alisa DeGrave1,2, Wolfram-Hubertus Zimmermann1,2,3,4,5, Susanne Lutz1,2 1Institute of Pharmacology and Toxicology, University Medical Center Goettingen, 2DZHK (German Center for Cardiovascular Research) partner site, Goettingen, 3Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of Goettingen, 4Center for Neurodegenerative Diseases (DZNE), 5Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP) JoVE 62700 Bio-ingénierie
Fibroblast Derived Human Engineered Connective Tissue for Screening Applications Gabriela L. Santos1,2, Tim Meyer1,2, Malte Tiburcy1,2, Alisa DeGrave1,2, Wolfram-Hubertus Zimmermann1,2,3,4,5, Susanne Lutz1,2 1Institute of Pharmacology and Toxicology, University Medical Center Goettingen, 2DZHK (German Center for Cardiovascular Research) partner site, Goettingen, 3Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of Goettingen, 4Center for Neurodegenerative Diseases (DZNE), 5Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP) JoVE 62700 Bio-ingénierie