Yan Chai CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology Chinese Academy of Sciences Biography Publications Institution JoVE Articles Yan Chai has not added a biography. If you are Yan Chai and would like to personalize this page please email our Author Liaison for assistance. Publications A Broadly Protective Antibody That Targets the Flavivirus NS1 Protein Science (New York, N.Y.). 01, 2021 | Pubmed ID: 33414219 Molecular Basis of EphA2 Recognition by GHgL from Gammaherpesviruses Nature Communications. 11, 2020 | Pubmed ID: 33235207 N-glycosylation of PD-1 Promotes Binding of Camrelizumab EMBO Reports. 12, 2020 | Pubmed ID: 33063473 Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy Against the Drifted Influenza Virus MBio. 10, 2020 | Pubmed ID: 33024040 Molecular Basis of Coxsackievirus A10 Entry Using the Two-in-one Attachment and Uncoating Receptor KRM1 Proceedings of the National Academy of Sciences of the United States of America. 08, 2020 | Pubmed ID: 32690697 The Structural Basis of African Swine Fever Virus PA104R Binding to DNA and Its Inhibition by Stilbene Derivatives Proceedings of the National Academy of Sciences of the United States of America. 05, 2020 | Pubmed ID: 32358196 The Identification of a CD47-blocking "hotspot" and Design of a CD47/PD-L1 Dual-specific Antibody with Limited Hemagglutination Signal Transduction and Targeted Therapy. 03, 2020 | Pubmed ID: 32296041 Crystal Structure of African Swine Fever Virus DUTPase Reveals a Potential Drug Target MBio. 10, 2019 | Pubmed ID: 31662460 Peptide Presentation by Bat MHC Class I Provides New Insight into the Antiviral Immunity of Bats PLoS Biology. 09, 2019 | Pubmed ID: 31498797 Divergent Peptide Presentations of HLA-A30 Alleles Revealed by Structures With Pathogen Peptides Frontiers in Immunology. 2019 | Pubmed ID: 31396224 Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development Cancer Immunology Research. 08, 2019 | Pubmed ID: 31213474 Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein Cell. 06, 2019 | Pubmed ID: 31080063 The FG Loop of PD-1 Serves As a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy IScience. Apr, 2019 | Pubmed ID: 30952089 Neutralization Mechanism of Human Monoclonal Antibodies Against Rift Valley Fever Virus Nature Microbiology. 07, 2019 | Pubmed ID: 30936489 Glycosylation-independent Binding of Monoclonal Antibody Toripalimab to FG Loop of PD-1 for Tumor Immune Checkpoint Therapy MAbs. May/Jun, 2019 | Pubmed ID: 30892132 Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab Cell Reports. 10, 2018 | Pubmed ID: 30355497 An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I Journal of Immunology (Baltimore, Md. : 1950). 11, 2018 | Pubmed ID: 30341185 Structural and Functional Insights into MCR-2 Mediated Colistin Resistance Science China. Life Sciences. Sep, 2018 | Pubmed ID: 30194678 Heterosubtypic Protections Against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses MBio. Aug, 2018 | Pubmed ID: 30087171 The Postfusion Structure of the Heartland Virus Gc Glycoprotein Supports Taxonomic Separation of the Bunyaviral Families Phenuiviridae and Hantaviridae Journal of Virology. 01, 2018 | Pubmed ID: 29070692 Distinct PD-L1 Binding Characteristics of Therapeutic Monoclonal Antibody Durvalumab Protein & Cell. Jan, 2018 | Pubmed ID: 28488247 Two Classes of Protective Antibodies Against Pseudorabies Virus Variant Glycoprotein B: Implications for Vaccine Design PLoS Pathogens. 12, 2017 | Pubmed ID: 29261802 Remarkably Similar CTLA-4 Binding Properties of Therapeutic Ipilimumab and Tremelimumab Antibodies Oncotarget. Sep, 2017 | Pubmed ID: 28978021 Structures of Phlebovirus Glycoprotein Gn and Identification of a Neutralizing Antibody Epitope Proceedings of the National Academy of Sciences of the United States of America. 09, 2017 | Pubmed ID: 28827346 Alternate Binding Modes of Anti-CRISPR Viral Suppressors AcrF1/2 to Csy Surveillance Complex Revealed by Cryo-EM Structures Cell Research. Jul, 2017 | Pubmed ID: 28574055 The Crystal Structure of Zika Virus NS5 Reveals Conserved Drug Targets The EMBO Journal. 04, 2017 | Pubmed ID: 28254839 An Unexpected N-terminal Loop in PD-1 Dominates Binding by Nivolumab Nature Communications. 02, 2017 | Pubmed ID: 28165004 Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC Journal of Immunology (Baltimore, Md. : 1950). 01, 2017 | Pubmed ID: 27903740 Structural Basis of Anti-PD-L1 Monoclonal Antibody Avelumab for Tumor Therapy Cell Research. Jan, 2017 | Pubmed ID: 27573173 Diversified Anchoring Features the Peptide Presentation of DLA-88*50801: First Structural Insight into Domestic Dog MHC Class I Journal of Immunology (Baltimore, Md. : 1950). 09, 2016 | Pubmed ID: 27511732 [Distribution of Organochlorine Pesticides in Surface Sediments from the Middle and Lower Reaches of the Yellow River] Huan Jing Ke Xue= Huanjing Kexue. Jun, 2007 | Pubmed ID: 17674745 蝙蝠主要组织兼容性复杂类 I 的稳定性和结构与异质β2- 微球蛋白 Di Zhang*1,2, Kefang Liu*3,4, Dan Lu*2,5, Pengyan Wang1,2, Qingxu Zhang1,2, Peipei Liu2, Yingze Zhao2, Yan Chai4, Jianxin Lyu1, Jianxun Qi4, William J. Liu1,2 1School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, 2NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 3Faculty of Health Sciences, University of Macau, 4CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, 5Savaid Medical School, University of Chinese Academy of Sciences JoVE 61462 Immunologie et Infection
蝙蝠主要组织兼容性复杂类 I 的稳定性和结构与异质β2- 微球蛋白 Di Zhang*1,2, Kefang Liu*3,4, Dan Lu*2,5, Pengyan Wang1,2, Qingxu Zhang1,2, Peipei Liu2, Yingze Zhao2, Yan Chai4, Jianxin Lyu1, Jianxun Qi4, William J. Liu1,2 1School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, 2NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 3Faculty of Health Sciences, University of Macau, 4CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, 5Savaid Medical School, University of Chinese Academy of Sciences JoVE 61462 Immunologie et Infection