Yoshihiro Sowa Department of Plastic and Reconstructive Surgery Kyoto Prefectural University of Medicine Biography Publications Institution JoVE Articles Yoshihiro Sowa has not added a biography. If you are Yoshihiro Sowa and would like to personalize this page please email our Author Liaison for assistance. Publications Mevalonate Pathway Blockage Enhances the Efficacy of MTOR Inhibitors with the Activation of Retinoblastoma Protein in Renal Cell Carcinoma Cancer Letters. Sep, 2018 | Pubmed ID: 29778569 The Histone Deacetylase Inhibitor OBP-801 and Eribulin Synergistically Inhibit the Growth of Triple-negative Breast Cancer Cells with the Suppression of Survivin, Bcl-xL, and the MAPK Pathway Breast Cancer Research and Treatment. May, 2018 | Pubmed ID: 29752686 Blockage of the Mevalonate Pathway Overcomes the Apoptotic Resistance to MEK Inhibitors with Suppressing the Activation of Akt in Cancer Cells Oncotarget. Apr, 2018 | Pubmed ID: 29731968 Design, Synthesis and Evaluation of γ-turn Mimetics As LSD1-selective Inhibitors Bioorganic & Medicinal Chemistry. 02, 2018 | Pubmed ID: 29331452 Using an In-House Approach to Computer-Assisted Design and Computer-Aided Manufacturing Reconstruction of the Maxilla Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons. Jun, 2018 | Pubmed ID: 29294353 FGFR Inhibitor BGJ398 and HDAC Inhibitor OBP-801 Synergistically Inhibit Cell Growth and Induce Apoptosis in Bladder Cancer Cells Oncology Reports. Feb, 2018 | Pubmed ID: 29207153 Retention of a Reconstructed Nipple Using a C-V Flap with Different Layer Thicknesses in the C-flap Journal of Plastic Surgery and Hand Surgery. Apr, 2018 | Pubmed ID: 28758551 Breast Volume Measurement by Recycling the Data Obtained From 2 Routine Modalities, Mammography and Magnetic Resonance Imaging Eplasty. 2017 | Pubmed ID: 29308107 Ribosomal Protein S3 Regulates XIAP Expression Independently of the NF-κB Pathway in Breast Cancer Cells Oncology Reports. Nov, 2017 | Pubmed ID: 29048653 Secondary Maxillary and Orbital Floor Reconstruction With a Free Scapular Flap Using Cutting and Fixation Guides Created by Computer-Aided Design/Computer-Aided Manufacturing The Journal of Craniofacial Surgery. Nov, 2017 | Pubmed ID: 28953152 Comparison of Morbidity-related Seroma Formation Following Conventional Latissimus Dorsi Flap Versus Muscle-sparing Latissimus Dorsi Flap Breast Reconstruction Annals of Surgical Treatment and Research. Sep, 2017 | Pubmed ID: 28932726 Dual Vascular Free Anterolateral Thigh Flap Plastic and Reconstructive Surgery. Global Open. Aug, 2017 | Pubmed ID: 28894667 Intraoperative Change in Defect Size During Maxillary Reconstruction Using Surgical Guides Created by CAD/CAM Plastic and Reconstructive Surgery. Global Open. Apr, 2017 | Pubmed ID: 28507870 Inverted Nipple Correction with Selective Dissection of Lactiferous Ducts Using an Operative Microscope and a Traction Technique Aesthetic Plastic Surgery. Oct, 2017 | Pubmed ID: 28409206 Evaluation of the Severity of Capsular Contracture Using Elastography After Breast Implant Reconstruction Clinical Hemorheology and Microcirculation. 2017 | Pubmed ID: 28211802 Direct Conversion of Human Fibroblasts into Schwann Cells That Facilitate Regeneration of Injured Peripheral Nerve In Vivo Stem Cells Translational Medicine. Apr, 2017 | Pubmed ID: 28186702 Molecular-targeting Therapies Against Quantitative Abnormalities in Gene Expression with Malignant Tumors Cancer Science. Apr, 2017 | Pubmed ID: 28178388 Long-term Prospective Assessment of Shoulder Function After Breast Reconstruction Involving a Latissimus Dorsi Muscle Flap Transfer and Postoperative Radiotherapy Breast Cancer (Tokyo, Japan). May, 2017 | Pubmed ID: 27379425 ERRATUM Oncology Research. Jan, 2016 | Pubmed ID: 29021025 Case Report of a Large Pigmented Epithelioid Melanocytoma With Suspected Lymph Node Metastases Eplasty. 2016 | Pubmed ID: 28066518 Targeting Cancer with PCPA-Drug Conjugates: LSD1 Inhibition-Triggered Release of 4-Hydroxytamoxifen Angewandte Chemie (International Ed. in English). 12, 2016 | Pubmed ID: 27882656 MEK Inhibitor Suppresses Expression of the MiR-17-92 Cluster with G1-Phase Arrest in HT-29 Human Colon Cancer Cells and MIA PaCa-2 Pancreatic Cancer Cells Anticancer Research. 09, 2016 | Pubmed ID: 27630293 Low-cost Design and Manufacturing of Surgical Guides for Mandibular Reconstruction Using a Fibula Plastic and Reconstructive Surgery. Global Open. Jul, 2016 | Pubmed ID: 27536484 Comparison of Shear-Wave and Strain Ultrasound Elastography for Evaluating Fat Induration After Breast Reconstruction Plastic and Reconstructive Surgery. Global Open. Apr, 2016 | Pubmed ID: 27200239 Preventive Effects on Seroma Formation with Use of the Harmonic Focus Shears After Breast Reconstruction with the Latissimus Dorsi Flap Journal of Plastic Surgery and Hand Surgery. Dec, 2016 | Pubmed ID: 27146859 Generation of Directly Converted Human Osteoblasts That Are Free of Exogenous Gene and Xenogenic Protein Journal of Cellular Biochemistry. 11, 2016 | Pubmed ID: 26990860 Use of Systemic Low-dose Unfractionated Heparin in Microvascular Head and Neck Reconstruction: Influence in Free-flap Outcomes Journal of Plastic Surgery and Hand Surgery. Jun, 2016 | Pubmed ID: 26937948 Adipose-Derived Stem Cells Promote Peripheral Nerve Regeneration In Vivo Without Differentiation into Schwann-Like Lineage Plastic and Reconstructive Surgery. Feb, 2016 | Pubmed ID: 26818322 Phosphorylated Retinoblastoma Protein is a Potential Predictive Marker of Irinotecan Efficacy for Colorectal Cancer International Journal of Oncology. Mar, 2016 | Pubmed ID: 26783196 [Corrigendum] Brassinin Induces G1 Phase Arrest Through Increase of P21 and P27 by Inhibition of the Phosphatidylinositol 3-kinase Signaling Pathway in Human Colon Cancer Cells International Journal of Oncology. Mar, 2016 | Pubmed ID: 26718100 The Anti-obesity Drug Orlistat Promotes Sensitivity to TRAIL by Two Different Pathways in Hormone-refractory Prostate Cancer Cells International Journal of Oncology. Feb, 2016 | Pubmed ID: 26648205 Ultrasound Shear-Wave Elastography for Follow-Up Fat Induration After Breast Reconstruction with an Autologous Flap Plastic and Reconstructive Surgery. Global Open. Sep, 2015 | Pubmed ID: 26495231 Resibufogenin Induces G1-Phase Arrest Through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells PloS One. 2015 | Pubmed ID: 26121043 Metformin Causes G1-Phase Arrest Via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity Through DR5 Up-Regulation in Pancreatic Cancer Cells PloS One. 2015 | Pubmed ID: 25955843 The Alkaloid Emetine Sensitizes Ovarian Carcinoma Cells to Cisplatin Through Downregulation of Bcl-xL International Journal of Oncology. Jan, 2015 | Pubmed ID: 25310746 Adipose-derived Stem Cells Promote Proliferation, Migration, and Tube Formation of Lymphatic Endothelial Cells in Vitro by Secreting Lymphangiogenic Factors Annals of Plastic Surgery. Jun, 2015 | Pubmed ID: 24401810 Myeloid Zinc Finger 1 Mediates Sulindac Sulfide-induced Upregulation of Death Receptor 5 of Human Colon Cancer Cells Scientific Reports. Aug, 2014 | Pubmed ID: 25102912 Xylarianaphthol-1, a Novel Dinaphthofuran Derivative, Activates P21 Promoter in a P53-independent Manner Bioorganic & Medicinal Chemistry Letters. Aug, 2014 | Pubmed ID: 24939757 The Novel HDAC Inhibitor OBP-801/YM753 Enhances the Effects of 5-fluorouracil with Radiation on Esophageal Squamous Carcinoma Cells Oncology Research. 2014 | Pubmed ID: 24854104 Peroxisome Proliferator-activated Receptor γ Ligand Troglitazone and TRAIL Synergistically Induce Apoptosis Oncology Reports. Feb, 2014 | Pubmed ID: 24276615 Adipose Stromal Cells Contain Phenotypically Distinct Adipogenic Progenitors Derived from Neural Crest PloS One. 2013 | Pubmed ID: 24391913 The Flavonoid Apigenin Downregulates CDK1 by Directly Targeting Ribosomal Protein S9 PloS One. 2013 | Pubmed ID: 24009741 Ibuprofen Enhances TRAIL-induced Apoptosis Through DR5 Upregulation Oncology Reports. Nov, 2013 | Pubmed ID: 24002210 Expansion Abdominoplasty for a Pregnant Woman with Severe Abdominal Wall Contracture Due to a Major Burn During Childhood: a Case Report Annals of Plastic Surgery. Jun, 2013 | Pubmed ID: 23673563 Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity Cancer Research. Jul, 2013 | Pubmed ID: 23667175 Molecular Mechanisms of the Antitumor Activity of SB225002: a Novel Microtubule Inhibitor Biochemical Pharmacology. Jun, 2013 | Pubmed ID: 23611835 Novel MEK Inhibitor Trametinib and Other Retinoblastoma Gene (RB)-reactivating Agents Enhance Efficacy of 5-fluorouracil on Human Colon Cancer Cells Cancer Science. Jun, 2013 | Pubmed ID: 23438367 Perillyl Alcohol Causes G1 Arrest Through P15(INK4b) and P21(WAF1/Cip1) Induction Oncology Reports. Feb, 2013 | Pubmed ID: 23233050 Does a Vascular Supercharge Improve the Clinical Outcome for Free Jejunal Transfer? Microsurgery. Mar, 2013 | Pubmed ID: 23161782 [Ras/Raf/MEK/ERK Cascade] Nihon Rinsho. Japanese Journal of Clinical Medicine. Nov, 2012 | Pubmed ID: 23513813 Retinoblastoma Gene-independent G1 Phase Arrest by Flavone, Phosphatidylinositol 3-kinase Inhibitor, and Histone Deacetylase Inhibitor Cancer Science. Dec, 2012 | Pubmed ID: 22957647 Surgical Treatment of Dumbbell-shaped Dermoid Cyst Extending into the Orbit The Journal of Craniofacial Surgery. Jul, 2012 | Pubmed ID: 22801126 Expression and Role of HMGA1 in Renal Cell Carcinoma The Journal of Urology. Jun, 2012 | Pubmed ID: 22503056 Successful Retrograde Arterial Inflow Through a Muscular Branch in a Free Anterolateral Thigh Chimeric Flap Transfer Microsurgery. May, 2012 | Pubmed ID: 22438088 The Anti-obesity Drug Orlistat Promotes Sensitivity to TRAIL by Two Different Pathways in Hormone-refractory Prostate Cancer Cells International Journal of Oncology. May, 2012 | Pubmed ID: 22328338 Brassinin Induces G1 Phase Arrest Through Increase of P21 and P27 by Inhibition of the Phosphatidylinositol 3-kinase Signaling Pathway in Human Colon Cancer Cells International Journal of Oncology. Mar, 2012 | Pubmed ID: 22307336 Adipose-derived Stem Cells Produce Factors Enhancing Peripheral Nerve Regeneration: Influence of Age and Anatomic Site of Origin Stem Cells and Development. Jul, 2012 | Pubmed ID: 22150084 Congenital Vulvar Lipoma Within an Accessory Labioscrotal Fold Pediatric Dermatology. Jul-Aug, 2011 | Pubmed ID: 21371114 Blood Gas Analyses in Doubly-vascularised Free Jejunal Transfers The British Journal of Oral & Maxillofacial Surgery. Mar, 2011 | Pubmed ID: 20338673 [Development of HDAC Inhibitors] Gan to Kagaku Ryoho. Cancer & Chemotherapy. Sep, 2010 | Pubmed ID: 20841929 A Novel MEK1/2 Inhibitor Induces G1/S Cell Cycle Arrest in Human Fibrosarcoma Cells Oncology Reports. Aug, 2010 | Pubmed ID: 20596617 Histone Deacetylase Inhibitors and 15-deoxy-Delta12,14-prostaglandin J2 Synergistically Induce Apoptosis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2010 | Pubmed ID: 20371690 Cyclin-dependent Kinase Inhibitor SU9516 Enhances Sensitivity to Methotrexate in Human T-cell Leukemia Jurkat Cells Cancer Science. Mar, 2010 | Pubmed ID: 20059476 Double Arterialized Free Jejunal Flap Journal of Reconstructive Microsurgery. Apr, 2010 | Pubmed ID: 19902405 Double Vascular Anastomosis in the Neck for Reliable Free Jejunal Transfer The British Journal of Oral & Maxillofacial Surgery. Oct, 2010 | Pubmed ID: 19850379 Artery-dominant Free Jejunal Transfer Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS. Mar, 2010 | Pubmed ID: 19230807 Normal Transvaginal Delivery After Abdominal Wall Reconstruction with Tensor Fascia Lata Muscle Flap Annals of Plastic Surgery. Jan, 2009 | Pubmed ID: 19131726 The Thoracoacromial Artery As the Recipient Artery for Safer Free Jejunal Transfer in Patients with Irradiated, Extensively Scarred Necks The British Journal of Oral & Maxillofacial Surgery. Jan, 2009 | Pubmed ID: 18597908 Smenospongine, a Sesquiterpene Aminoquinone from a Marine Sponge, Induces G1 Arrest or Apoptosis in Different Leukemia Cells Marine Drugs. 2008 | Pubmed ID: 19005580 Double Vascular Anastomosis for Safer Free Jejunal Transfer in Unfavorable Conditions Journal of Reconstructive Microsurgery. Oct, 2008 | Pubmed ID: 18798140 CDK Inhibitor Enhances the Sensitivity to 5-fluorouracil in Colorectal Cancer Cells International Journal of Oncology. May, 2008 | Pubmed ID: 18425338 Juvenile Xanthogranuloma Presenting Rapid Progression After Curettage: a Case Report with Clinicopathological Findings Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS. 2007 | Pubmed ID: 17950188 Sulforaphane Induces Cell Cycle Arrest and Apoptosis in Murine Osteosarcoma Cells in Vitro and Inhibits Tumor Growth in Vivo Oncology Reports. Nov, 2007 | Pubmed ID: 17914583 The Plant Alkaloid Cryptolepine Induces P21WAF1/CIP1 and Cell Cycle Arrest in a Human Osteosarcoma Cell Line International Journal of Oncology. Oct, 2007 | Pubmed ID: 17786325 A Novel Synthetic Drug, LB-18, Closely Related to Lembehyne-A Derived from a Marine Sponge, Induces Caspase-independent Cell Death to Human Neuroblastoma Cells International Journal of Oncology. Jul, 2006 | Pubmed ID: 16773197 Sulforaphane Enhances TRAIL-induced Apoptosis Through the Induction of DR5 Expression in Human Osteosarcoma Cells Carcinogenesis. Sep, 2006 | Pubmed ID: 16571651 Apigenin Induces Cell Cycle Arrest and P21/WAF1 Expression in a P53-independent Pathway International Journal of Oncology. Jan, 2005 | Pubmed ID: 15586239 Genistein Induces Gadd45 Gene and G2/M Cell Cycle Arrest in the DU145 Human Prostate Cancer Cell Line FEBS Letters. Nov, 2004 | Pubmed ID: 15527761 Histone Deacetylase Inhibitors -Promising Agents for 'gene-regulating Chemoprevention' and 'molecular-targeting Prevention' of Cancer- Environmental Health and Preventive Medicine. Nov, 2003 | Pubmed ID: 21432092 P53-independent Induction of Gadd45 by Histone Deacetylase Inhibitor: Coordinate Regulation by Transcription Factors Oct-1 and NF-Y Oncogene. Oct, 2003 | Pubmed ID: 14586402 [Gene-regulating Chemoprevention Against Cancer--as a Model for "molecular-targeting Prevention" of Cancer] Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene. May, 2003 | Pubmed ID: 12806965 Telomerase Activation by Histone Deacetylase Inhibitor in Normal Cells Nucleic Acids Research. Jul, 2001 | Pubmed ID: 11452025 Cell Cycle-dependent Modulation of Promoter Activities of RB and WAF1/Cip1 Genes Japanese Journal of Cancer Research : Gann. Jun, 1998 | Pubmed ID: 9703360 Designing CAD/CAM Surgical Guides for Maxillary Reconstruction Using an In-house Approach Toshiaki Numajiri1, Daiki Morita2, Hiroko Nakamura3, Ryo Yamochi1, Shoko Tsujiko4, Yoshihiro Sowa1 1Department of Plastic and Reconstructive Surgery, Kyoto Prefectural University of Medicine, 2Department of Plastic and Reconstructive Surgery, Showa University Fujigaoka Hospital, 3Department of Plastic and Reconstructive Surgery, Fukuchiyama City Hospital, 4Department of Plastic and Reconstructive Surgery, Saiseikai Shiga Hospital JoVE 58015 Médecine
Designing CAD/CAM Surgical Guides for Maxillary Reconstruction Using an In-house Approach Toshiaki Numajiri1, Daiki Morita2, Hiroko Nakamura3, Ryo Yamochi1, Shoko Tsujiko4, Yoshihiro Sowa1 1Department of Plastic and Reconstructive Surgery, Kyoto Prefectural University of Medicine, 2Department of Plastic and Reconstructive Surgery, Showa University Fujigaoka Hospital, 3Department of Plastic and Reconstructive Surgery, Fukuchiyama City Hospital, 4Department of Plastic and Reconstructive Surgery, Saiseikai Shiga Hospital JoVE 58015 Médecine