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The use of SC1 (Pluripotin) to Support mESC Self-renewal in the Absence of LIF
 

The use of SC1 (Pluripotin) to Support mESC Self-renewal in the Absence of LIF

Article DOI: 10.3791/1550-v • 05:59 min • November 18th, 2009
November 18th, 2009 •
1, 1, 1, 1, 1, 1, 2, 1
1Research and Development, Stemgent, 2Product Marketing, Stemgent

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SC1 functions through dual inhibition of Ras- GAP and ERK1. We tested the function of SC1 in supporting mouse ES cell self-renewal in the absence of LIF and showed that SC1 is able to maintain self-renewal of mouse ES cell cultures.

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SC1 Pluripotin MESC Self-renewal LIF SC1 Mechanism Of Action Ras-GAP ERK1 Inhibition Economical Alternative To LIF Molecular Mechanism Of Self-renewal Culturing Mouse ES Cells With SC1 Morphology Of Mouse ES Cells Pluripotency Markers Oct4 Sox2 Nanog SSEA1 Toxicity On Mouse ES Cells
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