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Determining the End-Systolic and End-Diastolic Pressure-Volume Relationships in a Murine Heart Failure Model and Transesophageal Pacing
 

Determining the End-Systolic and End-Diastolic Pressure-Volume Relationships in a Murine Heart Failure Model and Transesophageal Pacing

Exploring HR-Dependent Cardiac Performance Using an Atrial-Pacing Protocol

Article DOI: 10.3791/200330-v • 03:15 min • July 21st, 2023
July 21st, 2023 •
1,2, 1,3
1Department of Cardiovascular Medicine, The University of Tokyo Hospital, 2Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, The University of Tokyo, 3Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions

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Pacing-controlled Procedure Assessment Heart Rate-dependent Diastolic Functions Murine Heart Failure Models Heart Failure With Preserved Ejection Fraction HFpEF Diastolic Dysfunction Exercise Intolerance Hemodynamic Tests MRI Basic Research Mouse Models Treadmill Exercise Test Body Weight Skeletal Muscle Strength Mental State Atrial-pacing Protocol Heart Rate Changes Diastolic Performance Mouse Model Of HFpEF Anesthetizing Intubating Pressure-volume Loop Analysis Conductance Catheter Atrial Pacing Catheter Ivabradine HR Increments Bpm (beats Per Minute) Diastolic Impairment Metabolically Induced HFpEF Model Relaxation Time Constant (Tau) End-diastolic Pressure-volume Relationship (EDPVR)
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