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Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
 

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Article DOI: 10.3791/224-v • 26:48 min • July 4th, 2007
July 4th, 2007 •
1, 1, 1
1Department of Physiology and Biophysics, University of California, Irvine (UCI)

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This video demonstrates the induction and clinical scoring of an animal model of multiple sclerosis: chronic-relapsing experimental autoimmune encephalomyelitis in DA rats. The disease, induced by immunizing rats with an emulsion containing whole rat spinal cord and complete Freund's adjuvant, presents clinical signs resembling the human disease.

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Induction Clinical Scoring Chronic-Relapsing Experimental Autoimmune Encephalomyelitis Multiple Sclerosis Chronic Inflammatory Disease Central Nervous System Demyelination Glial Scaring Brain Spinal Cord Demyelinated Plaques Paraparesis Paralysis Blindness Incontinence Experimental Autoimmune Encephalomyelitis (EAE) MS Model Vaccination Rabies Viruses Grown On Rabbit Spinal Cords CNS Disease Non-human Primates Immunized With A CNS Homogenate Species/strain Immunizing Antigen Lewis Rats Myelin Basic Protein In Emulsion With Adjuvant Guinea Pigs DA Rats DA Rat Spinal Cord Complete Freund's Adjuvant Ascending Flaccid Paralysis
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