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Ex Vivo Culture of Primary Human Fallopian Tube Epithelial Cells
 

Ex Vivo Culture of Primary Human Fallopian Tube Epithelial Cells

Article DOI: 10.3791/2728-v • 11:47 min • May 9th, 2011
May 9th, 2011 •
1,2, 1,2,3, 1,2,4
1Department of Medical Oncology, Dana-Farber Cancer Institute, 2Harvard Medical School, Boston, MA, 3Sheba Cancer Research Center, Chaim Sheba Medical Center, 4Department of Pathology, Brigham and Women's Hospital

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résumé
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The fallopian tube (FT) is emerging as an alternative site of origin for serous ovarian carcinoma (SOC). This protocol describes a novel method for the isolation and ex vivo culture of fallopian tube epithelial cells. This system recapitulates the in vivo epithelium and allows the study of SOC pathogenesis.

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Ex Vivo Culture Primary Human Fallopian Tube Epithelial Cells Epithelial Ovarian Cancer Female Cancer Mortality United States Breast Carcinoma Uterine Carcinoma Ovarian Cancer Cure Rates Screening Tools Early Stage Disease Detection Surgery Chemotherapy Advanced Stage Disease Diffuse Abdominal Involvement Heterogeneous Disease Histologic Subtypes Serous Ovarian Carcinoma (SOC) BRCA Genes Mutations Experimental Models Cancer Cell Lines Mouse Models Initiating Genetic Events Pathogenesis Of Disease Fallopian Tube Origin Of SOC Fallopian Tube Secretory Epithelial Cell (FTSEC) Cell Lines Culture Systems
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