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Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase (COX/SDH) Double-labeling Histochemistry
 

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase (COX/SDH) Double-labeling Histochemistry

Article DOI: 10.3791/3266-v • 06:54 min • November 23rd, 2011
November 23rd, 2011 •
1,2
1Department of Neuroscience, Karolinska Institutet, 2National Institute on Drug Abuse (NIDA)

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The cytochrome c oxidase/sodium dehydrogenase (COX/SDH) double-labeling method allows for direct visualization of mitochondrial respiratory enzyme deficiencies in fresh-frozen tissue sections. This is a straightforward histochemical technique and is useful in investigating mitochondrial diseases, aging, and aging-related disorders.

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Mitochondrial Respiratory Function Cytochrome C Oxidase Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry Mitochondrial DNA Defects MtDNA Mutations Bioenergetics Homeostasis Cellular Function Mitochondrial Theory Of Aging MtDNA Damage Respiratory Enzymes Cytochrome C Oxidase (COX) MtDNA Integrity Succinate Dehydrogenase (SDH) Nuclear DNA Mitochondrial Diseases Aging Age-related Diseases
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