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JoVE Journal Medicine
Photothrombotic Ischemia
 

Photothrombotic Ischemia: A Minimally Invasive and Reproducible Photochemical Cortical Lesion Model for Mouse Stroke Studies

Article DOI: 10.3791/50370-v • 08:41 min • June 9th, 2013
June 9th, 2013 •
1,2,3, 2,3,4
1Department of Neuroscience, University of Turin, 2Neuroscience Institute of Turin (NIT), University of Turin, 3Neuroscience Institute Cavalieri-Ottolenghi (NICO), University of Turin, 4Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin

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Photothrombosis is a quick, minimally-invasive technique for inducing small and well-delimited infarction in areas of interest in highly reproducible manner. It is particularly suitable for studying cellular and molecular responses underlying brain plasticity in transgenic mice.

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Photothrombotic Ischemia Minimally Invasive Reproducible Photochemical Cortical Lesion Model Mouse Stroke Studies Ischemic Damage Photo-activation Light-sensitive Dye Singlet Oxygen Endothelial Cell Membranes Platelet Aggregation Thrombi Formation Interruption Of Local Blood Flow Rosenblum And El-Sabban Watson Transgenic Mouse Lines Photosensitive Dye Rose Bengal Intraperitoneal Injection Cold Light Source Endothelial Damage Platelet Activation Thrombosis Local Blood Flow Interruption Intact Skull Craniotomy Cortical Area Of Interest Non-invasive Triphenyl-tetrazolium Chloride Staining Cresyl Violet Staining
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