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Bioengineering

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JoVE Journal Bioengineering
Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration
 

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Article DOI: 10.3791/50532-v • 10:03 min • January 20th, 2014
January 20th, 2014 •
*1, *1, 1, 1,2
1Department of Cell and Developmental Biology, University College London, 2Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Hospital
* These authors contributed equally

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résumé
Automatic Translation

Induced pluripotent stem cell (iPSC)-derived myogenic progenitors are promising candidates for cell therapy strategies to treat muscular dystrophies. This protocol describes transplantation and functional measurements required to evaluate the engraftment and differentiation of iPSC-derived mesoangioblasts (a type of muscle progenitors) in mouse models of acute and chronic muscle regeneration.

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Transplantation Induced Pluripotent Stem Cells Mesoangioblast-like Myogenic Progenitors Muscle Regeneration Autologous Cell Therapy Muscular Dystrophy Genetic Correction Myogenesis Regulator MyoD In Vitro Differentiation Assays Immunofluorescence Analysis In Vivo Transplantation Mouse Models Acute And Chronic Muscle Regeneration Functional Tests Treadmill Tests Cell Engraftment Differentiation Histological Assays
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