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JoVE Journal Bioengineering
Imaging of Biological Tissues by Desorption Electrospray Ionization Mass Spectrometry
 

Imaging of Biological Tissues by Desorption Electrospray Ionization Mass Spectrometry

Article DOI: 10.3791/50575-v • 06:21 min • July 12th, 2013
July 12th, 2013 •
*1, *1, 1
1School of Chemistry and Biochemistry, Georgia Institute of Technology
* These authors contributed equally

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résumé
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Desorption electrospray ionization mass spectrometry (DESI-MS) is an ambient method by which samples, including biological tissues, can be imaged with minimal sample preparation. By rastering the sample below the ionization probe, this spray-based technique provides sufficient spatial resolution to discern molecular features of interest within tissue sections.

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Keywords: Mass Spectrometry Imaging DESI Desorption Electrospray Ionization Ambient Ionization Biological Tissue Rat Brain Sample Preparation Spatial Resolution Molecular Information
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