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JoVE Journal Behavior
A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats
 

A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats

Article DOI: 10.3791/50751-v • 10:35 min • November 11th, 2013
November 11th, 2013 •
1, 1, 1
1Department of Psychology, Center for Studies in Behavioural Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University

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résumé
Automatic Translation

A procedure that allows a demonstration of robust augmentation of drug seeking in food-restricted rats is described. Following heroin self-administration training, rats go through an abstinence period, in a drug-free environment, during which they are mildly food restricted. Drug seeking is then tested in the drug-associated environment.

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Keywords: Heroin Seeking Food Restriction Abstinence Relapse Drug Craving Intravenous Self-administration Operant Conditioning Extinction Animal Model Clinical Relevance
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