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JoVE Journal Neuroscience
Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans
 

Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans

Article DOI: 10.3791/50864-v • 07:35 min • February 4th, 2014
February 4th, 2014 •
1,2, 1,2
1Department of Psychiatry, Harvard Medical School, 2Mailman Research Center, McLean Hospital

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Approaches for testing the effects of antipsychotic drugs (APDs) in Caenorhabditis elegans are demonstrated. Assays are described for testing drug effects on development and viability and on pharyngeal pumping rate. These methods are also applicable for pharmacogenetic experiments with drug classes other than APDs.

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Keywords: Caenorhabditis Elegans Antipsychotic Drugs Pharmacogenetic Studies Developmental Assay Pharyngeal Pumping Neurotransmitter Synthesis Synaptic Structure And Function Forward And Reverse Genetic Screens Chemical Genetic Screens
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