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Reconstruction of 3-Dimensional Histology Volume and its Application to Study Mouse Mammary Glands
 

Reconstruction of 3-Dimensional Histology Volume and its Application to Study Mouse Mammary Glands

Article DOI: 10.3791/51325-v • 10:59 min • July 26th, 2014
July 26th, 2014 •
1, 2,3, 2,3, 4, 5, 6, 1,4, 2,3
1Department of Medical Biophysics, University of Toronto, 2Platform Biological Sciences, Sunnybrook Research Institute, 3Department of Laboratory Medicine and Pathobiology, University of Toronto, 4Physical Sciences, Sunnybrook Research Institute, 5Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 6Manitoba Institute of Cell Biology, University of Manitoba

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résumé
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We present an image registration approach for 3-dimensional (3D) histology volume reconstruction, which facilitates the study of the changes of an organ at the level of macrostructures made up of cells . Using this approach, we studied the 3D changes between wild-type and Igfbp7-null mammary glands.

Tags

Histology 3D Reconstruction Volume Change Organ Macrostructures Cells Medical Imaging Therapies Atlases Image Registration Optical Blockface Images Hematoxylin And Eosin (H&E) Mouse Mammary Glands Accuracy Alignment Macrostructures High Resolution Image Registration Pipeline
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