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Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
 

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Article DOI: 10.3791/52665-v • 10:04 min • May 1st, 2015
May 1st, 2015 •
*1,4, *1,2, 1, 1,3
1Department of Internal Medicine V, Innsbruck Medical University, 2Oncotyrol GmbH, 3Tyrolean Cancer Research Institute, 4Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute
* These authors contributed equally

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résumé
Automatic Translation

Human multiple myeloma (MM) cells require the supportive microenvironment of mesenchymal cells and extracellular matrix components for survival and proliferation. We established an in vivo chicken embryo model with engrafted human myeloma and mesenchymal cells to study effects of cancer drugs on tumor growth, invasion and angiogenesis.

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Human Multiple Myeloma Xenograft Model Tumor Growth Invasion Angiogenesis MM Cells Novel Therapeutics In Vitro Culture System In Vivo Culture System 3D Environment Human Mesenchymal Cells Collagen Type-I Matrix Chorioallantoic Membrane (CAM) Chicken Embryos Stereo Fluorescence Microscopy Quantification Of Tumor Cell Mass GFP-ELISA Angiogenic Responses Invasion Of Tumor Cells Immunohistochemical Staining
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