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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
 

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Article DOI: 10.3791/52757-v • 07:35 min • June 23rd, 2015
June 23rd, 2015 •
1, 2, 1, 2
1Department of Internal Medicine, Division of Nephrology, Mayo Clinic, 2Department of Biochemistry and Molecular Biology, Mayo Clinic

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The use of ultra-high field MRI as a non-invasive way to obtain phenotypic information of rodent models for polycystic kidney disease and to monitor interventions is described. Compared with the traditional histological approach, MRI images can be acquired in vivo, allowing for longitudinal follow-up.

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Ultra-high Field MRI Small Rodent Models Polycystic Kidney Disease In Vivo Phenotyping Drug Monitoring Pre-clinical Studies Genetic Mechanisms Molecular Mechanisms Rapid Drug Screening Promising Therapies Non-invasive Methods Anatomical Changes Functional Changes Magnetic Resonance Imaging Gold Standard Imaging Technique Autosomal Dominant Polycystic Kidney Disease Total Kidney Volume Measurements Longitudinal Studies Same Animal Reducing Total Number Of Animals Required
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