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Neuroscience

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JoVE Journal Neuroscience
Implantation of Miniosmotic Pumps and Delivery of Tract Tracers to Study Brain Reorganization in Pathophysiological Conditions
 

Implantation of Miniosmotic Pumps and Delivery of Tract Tracers to Study Brain Reorganization in Pathophysiological Conditions

Article DOI: 10.3791/52932-v • 10:32 min • January 18th, 2016
January 18th, 2016 •
1, 1,2,3, 2, 1, 1
1Department of Neurology, University of Duisburg-Essen, 2Neuroscience Unit, Institute for Advanced Studies (IDEA), 3Department of Cell Biology, Simon Bolivar University

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In order to study brain reorganization under pathological conditions we used miniosmotic pumps for direct protein delivery into the brain circumventing the blood brain barrier. Tract tracers are then injected to study alterations in brain connectivity under the influence of the protein.

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Implantation Mini-osmotic Pumps Therapeutic Agents Brain Tract Tracers Corticospinal Tract Conductivity Neurorestorative Research Long Distance Connections Continuous Delivery Reproducibility Morphological Changes Precision Surgical Abilities Brain Damage Interventions Sterile Environment Brain Infusion Cannula Cyanoacrylate Adhesive Spacer Disk Drug Delivery Catheter Flow Moderator Air Bubbles
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