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Immunology and Infection

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JoVE Journal Immunology and Infection
A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
 

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Article DOI: 10.3791/53084-v • 10:10 min • October 5th, 2015
October 5th, 2015 •
1, 2, 2, 1, 1,2
1Department of Clinical and Experimental Medicine, Linköping University, 2Department of Medicine, Karolinska Institute

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Human tuberculosis infection is a complex process, which is difficult to model in vitro. Here we describe a novel 3D human lung tissue model that recapitulates the dynamics that occur during infection, including the migration of immune cells and early granuloma formation in a physiological environment.

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Keywords: 3D Lung Tissue Model Mycobacterium Tuberculosis Tuberculosis In Vitro Model Tissue-specific Cells Granuloma Host-pathogen Interactions Lung Infection Organotypic Culture Quantitative Analysis
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