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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
 

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Article DOI: 10.3791/53319-v • 12:04 min • November 1st, 2015
November 1st, 2015 •
1, 1
1Division of Immunobiology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine

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The transfer of bm12 lymphocytes into a C57BL/6 recipient is an established model of systemic lupus erythematosus. Here we describe how to initiate disease using this model and how to characterize T follicular helper cells, germinal center B cells and plasma cells by flow cytometry.

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Keywords: Systemic Lupus Erythematosus SLE Bm12 Model C57BL/6 Mice T Follicular Helper Cells Tfh Germinal Center B Cells GC B Cells Plasma Cells Autoimmunity Flow Cytometry
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