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Bioengineering

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JoVE Journal Bioengineering
Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture
 

Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture

Article DOI: 10.3791/53431-v • 08:28 min • May 26th, 2016
May 26th, 2016 •
1, 2, 3, 2, 1, 2, 4, 1
1Department of Chemical Engineering and Centre for Regenerative Medicine, University of Bath, 2MRC Centre for Drug Safety Science and Institute of Translational Medicine, University of Liverpool, 3Mechanical Engineering, University College London, 4Department of Applied Mathematics, Liverpool John Moores University

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The functional behavior of cells in culture can be improved by culturing in more in vivo-like 3-dimensional culture environments16-21. This manuscript describes the set-up and operation of a hollow fiber bioreactor system for in vivo-like mammalian tissue culture.

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Keywords: Hollow Fiber Bioreactor In Vitro Model Liver Cell Function Physiologically Relevant Environment Sinusoid Bile Canaliculi Cell Culture Drug Dosing Borosilicate Glass Siliconizing Autoclave Silicone Glue PTFE Tape Ethanol Sterilization Pump Tubing Module Connectors Permeate Line Retentate Line
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