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Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema
 

Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema

Article DOI: 10.3791/54170-v • 08:44 min • September 1st, 2016
September 1st, 2016 •
1, 1, 2
1Neurotrauma Research, Swedish Medical Center, 2Neurosurgery, Colorado Brain and Spine Institute

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Our studies have revealed that the beneficial effects of conivaptan are dependent on the method of delivery after experimental stroke in mice. We have developed a research protocol for delivery of the receptor blocker via IV catheter on stroke-evoked brain edema formation in mice.

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Keywords: IV Infusion Arginine-vasopressin Receptor Blocker Conivaptan Mouse Model Stroke Brain Edema Delivery Route Pre-clinical Study Nylon Suture Dental Resin Carotid Artery Microvascular Clip Bupivacaine
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