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Immunology and Infection

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JoVE Journal Immunology and Infection
Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
 

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Article DOI: 10.3791/54348-v • 09:39 min • September 12th, 2016
September 12th, 2016 •
*1, *2, 1, 2, 1,3,4
1Physical Medicine and Rehabilitation, University of Alabama at Birmingham, 2Department of Pathology, University of Alabama at Birmingham, 3Department of Neurobiology, University of Alabama at Birmingham, 4Center for Glial Biology and Medicine, University of Alabama at Birmingham
* These authors contributed equally

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résumé
Automatic Translation

This protocol describes how to determine whether pharmacological treatments for experimental autoimmune encephalomyelitis show CNS protection as a consequence of suppressing immune cell infiltration or are neuroprotective during the onslaught of immune cell infiltration.

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Keywords: Immune System Suppression CNS Protection Pharmacological Interventions Autoimmune Demyelination Experimental Autoimmune Encephalomyelitis (EAE) Multiple Sclerosis System Xc-transporter Inhibitor Cell Isolation Density Gradient Myelin Cell Culture Restimulation
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