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Immunology and Infection

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JoVE Journal Immunology and Infection
Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
 

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Article DOI: 10.3791/54440-v • 06:32 min • September 19th, 2016
September 19th, 2016 •
1, 1, 1, 1
1Department of Microbiology, University of Zaragoza

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résumé
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We herein detail the methodology followed to compare protective efficacy and lung immune response induced by intranasal and subcutaneous immunization with BCG in mouse model. Our results show the benefits of pulmonary vaccination and suggest a role for IL17-mediated response in vaccine-induced protection.

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Keywords: BCG Vaccine Tuberculosis Protective Efficacy Pulmonary Immune Response Subcutaneous Administration Intranasal Administration Intranasal Challenge Bronchoalveolar Lavage Lung Immune Response
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