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Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model
 

Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model

Article DOI: 10.3791/54755-v • 08:33 min • November 24th, 2016
November 24th, 2016 •
1, 2, 3, 3
1Department of Surgery, University of California, Los Angeles, 2Molecular Biology Institute, University of California, Los Angeles, 3Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles

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Understanding the cellular and molecular mechanisms of re-endothelialization following arterial denudation injury is of paramount importance in preventing thrombosis and restenosis of arteries. Here we describe a protocol for reproducible arterial denudation injury of the infrarenal abdominal aorta. The procedure was developed to investigate the underlying mechanisms that regulate endothelial regeneration using mouse models.

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Keywords: Arterial Denudation Aortic Clamping Murine Model Vascular Biology Endothelial Regeneration Endothelial Cell Progenitors Vascular Injury Re-endothelialization Thrombotic Events Stent Deployment Coronary Artery Disease Peripheral Vascular Disease Surgical Procedure Anesthesia Abdominal Incision Intestine Retraction Retroperitoneal Dissection Aortic Exposure
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