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Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
 

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Article DOI: 10.3791/54798-v • 13:38 min • January 18th, 2017
January 18th, 2017 •
1, 2, 3, 2, 1
1Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 2Medicinal Chemistry and Pharmacognosy, College of Medicine, University of Illinois at Chicago, 3College of Pharmacy, University of Illinois at Chicago

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résumé
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This procedure will demonstrate how we synthesized and characterized the anti-NFκB and anti-cancer stem cell activity of an aspirin-fumarate prodrug.

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Synthesis Characterization Aspirin-fumarate Prodrug NF& 954;B Activity Breast Cancer Stem Cells Anti-inflammatory Drugs Multidisciplinary Approach Repurpose Therapy Resistant Breast Cancer Cells Plastic Plunger Syringe Methanol Water Round-bottom Flask 4-hydroxybenzyl Alcohol O-acetylsalicyloyl Chloride Anhydrous Toluene
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