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JoVE Journal Cancer Research
Synthesis and Characterization of Placental Chondroitin Sulfate A (plCSA)-Targeting Lipid-Polymer Nanoparticles
 

Synthesis and Characterization of Placental Chondroitin Sulfate A (plCSA)-Targeting Lipid-Polymer Nanoparticles

Article DOI: 10.3791/58209-v • 05:55 min • September 18th, 2018
September 18th, 2018 •
*1, *2,3, 2, 1
1Laboratory for Reproductive Health, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS), 2Guangdong Key Laboratory of Nanomedicine, CAS Key Lab for Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS), 3Department of Chemistry, Guangdong Medical University
* These authors contributed equally

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Here, we present a protocol for the synthesis of placental chondroitin sulfate A binding peptide (plCSA-BP)-conjugated lipid-polymer nanoparticles via single-step sonication and bioconjugate techniques. These particles constitute a novel tool for the targeted delivery of therapeutics to most human tumors and placental trophoblasts to treat cancers and placental disorders.

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Keywords: Placental Chondroitin Sulfate A PlCSA Lipid-polymer Nanoparticles Targeted Drug Delivery PLGA DOX EDC NHS Amine Reaction Dialysis Cell Culture Nanoparticle Uptake
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