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Uncontrolled Hemorrhagic Shock Modeled via Liver Laceration in Mice with Real Time Hemodynamic Monitoring
 

Uncontrolled Hemorrhagic Shock Modeled via Liver Laceration in Mice with Real Time Hemodynamic Monitoring

Article DOI: 10.3791/55554-v • 06:11 min • May 21st, 2017
May 21st, 2017 •
1, 1, 1, 1, 2, 1
1Department of Surgery, University of Pittsburgh, 2Department of Biomedical Engineering, Case Western Reserve University

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Uncontrolled hemorrhage, an important cause of mortality among trauma patients, can be modeled using a standard liver laceration in a murine model. This model results in consistent blood loss, survival, and allows for testing hemostatic agents. This article provides the step-by-step process to perform this valuable model.

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