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Cancer Research

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JoVE Journal Cancer Research
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
 

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Article DOI: 10.3791/55952-v • 06:01 min • July 6th, 2017
July 6th, 2017 •
1, 1, 2, 1, 1, 1, 3, 1,4,5, 1, 1,4,5
1Department of Gastrointestinal, Thoracic and Vascular Surgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, 2Department of General, Gastrointestinal and Transplant Surgery, University of Heidelberg, 3Department of Pathology, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, 4German Cancer Consortium (DKTK), 5German Cancer Research Center (DKFZ)

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résumé
Automatic Translation

A protocol for the establishment of a genetically engineered mouse model of colorectal cancer by segmental adeno-cre infection and its surveillance via high-resolution colonoscopy is presented.

Tags

Genetically Engineered Mouse Model Sporadic Colorectal Cancer Adeno-cre Infection Segmental Infection CRC Biology CRC Treatment Small Rodent Surgery Reproducible Tumors Colon-localized Tumors Anesthetized Mouse Sedation Level Midline Incision Abdominal Cavity Distal Colon Teflon Tube Insertion Luminal Occlusion Cannula Connection Saline Flush
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