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Behavior

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JoVE Journal Behavior
Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein
 

Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein

Article DOI: 10.3791/56157-v • 08:28 min • July 29th, 2018
July 29th, 2018 •
*1,3,5, *1,3,4, *2, 2,3, 1,3,4, 1,3,4
1Institute of Traditional Chinese Medicine, Chengde Medical College, 2Shijiazhuang Obstetrics and Gynecology Hospital, 3Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, 4Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, 5Institute of Basic Medical Research of Basic Medical School
* These authors contributed equally

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Automatic Translation

This is a protocol to mimic Alzheimer's Disease in rats by evaluation of spatial memory impairment, neuronal pathological changes, neuronal amyloid beta protein (Aβ) burden, and neurofibrillary tangles aggregation, induced by the injection of Aβ25-35 combined with aluminum trichloride and recombinant human transforming growth factor-β1.

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Alzheimer's Disease Rat Animal Model Intracerebroventricular Injection Composited Amyloid Beta Protein Neurodegenerative Disease Field A-beta 25 To 35 Aluminum Trichloride Recombinant Human Transforming Growth Factor Beta One Drug Screening Memory Impairments Neuronal Disturbance Laboratory Technician Surgical Procedure
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