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JoVE Journal Neuroscience
Laminotomy for Lumbar Dorsal Root Ganglion Access and Injection in Swine
 

Laminotomy for Lumbar Dorsal Root Ganglion Access and Injection in Swine

Article DOI: 10.3791/56434-v • 09:00 min • October 10th, 2017
October 10th, 2017 •
1, 2, 3, 1, 4, 1
1Departments of Anesthesiology and Oncology, Mayo Clinic, Translational Science Track, Mayo Graduate School, 2Department of Radiology (Section of Interventional Pain Management), Mayo Clinic, 3Department of Neurologic Surgery, Mayo Clinic, 4Department of Orthopedic Surgery, Mayo Clinic

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Automatic Translation

We describe a method for laminotomy in swine that provides access to lumbar dorsal root ganglia (DRG) for intraganglionic injection. Injection progress is monitored intraoperatively and histologically confirmed up to 21 days after surgery. This protocol could be used for future preclinical studies involving DRG injection.

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Laminotomy Lumbar Dorsal Root Ganglion Swine Intraganglionic Injection Convection-enhanced Delivery Needle Neuroscience Drug Effect DRG Cells Parenchyma Technical Data Biological Replicates Reference Standard Image-guided Delivery Therapeutic Efficacy Delivery Efficiency Anesthesia Surgical Positioning Abdominal Aperture Skin Preparation Surgical Scrub Transverse Processes Incision Site
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