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JoVE Journal Neuroscience
Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
 

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Article DOI: 10.3791/56651-v • 09:39 min • February 13th, 2018
February 13th, 2018 •
1,2, 3, 1,2
1Department of Anatomy, School of Medicine, College of Medicine, Kaohsiung Medical University, 2Department of Medical Research, Kaohsiung Medical University Hospital, 3Department of Medical Research, Ultrastructural Laboratory, Kaohsiung Medical University Hospital

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This study establishes an experimental model of pure small fiber neuropathy with resiniferatoxin (RTX). A unique dose of RTX (50 µg/kg) is optimal for developing a small fiber neuropathy model that mimics patient characteristics and could help investigate the nociceptive molecular significance underlying neuropathic pain.

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Keywords: Mouse Model Small Fiber Neuropathy Transient Receptor Potential Vanilloid Type 1 Resiniferatoxin RTX Hot Plate Test Von Frey Hair Filaments Sensory Neuropathy Neurotoxin Delivery
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