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Bioengineering

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JoVE Journal Bioengineering
Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating
 

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating

Article DOI: 10.3791/56879-v • 05:35 min • June 23rd, 2018
June 23rd, 2018 •
1, 1, 1, 1
1Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College

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This protocol aims to achieve surface engineering of pancreatic islets using a heparin-incorporated starPEG nanocoating via pseudo-bioorthogonal chemistry between the N-hydroxysuccinimide groups of the nanocoating and the amine groups of islet cell membrane.

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Keywords: Pancreatic Islet Surface Engineering Heparinized StarPEG Nanocoating Islet Transplantation Cell-based Therapy Immuno-rejection Revascularization Survival Graft Function Therapeutic Efficacy Cell Retention Cell Survival Heparin NHS EDC StarPEG Mouse Islets PBS RPMI 1640 FBS
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