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Assessment of Kidney Function in Mouse Models of Glomerular Disease
 

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Article DOI: 10.3791/57764-v • 09:16 min • June 30th, 2018
June 30th, 2018 •
1,2,3, 1,2,3
1Institute of Biomedical and Clinical Sciences, Medical School, University of Exeter, 2School of Physiology, Pharmacology and Neurosciences, University of Bristol, 3Bristol Renal, School of Clinical Sciences, University of Bristol

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résumé
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This protocol describes a full kidney work-up that should be carried out in mouse models of glomerular disease. The methods allow for detailed functional, structural, and mechanistic analysis of glomerular function, which can be applied to all mouse models of glomerular disease.

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Kidney Function Assessment Glomerular Disease Mouse Models Functional Phenotype Structural Phenotype Urinary Albumin Creatinine Ratio Metabolic Mouse Cage Urine Sample Collection Kidney Harvest Cortical Glomeruli Examination Juxtamedullary Glomeruli Examination Electron Microscopy Vials Glutaraldehyde Solution Histology Paraformaldehyde
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