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Chemistry

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JoVE Journal Chemistry
Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production
 

Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production

Article DOI: 10.3791/58428-v • 10:20 min • October 26th, 2018
October 26th, 2018 •
*1, *2,3, 2,4, 1, 2,3, 2,4
1SOFIE, 2Department of Molecular & Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), 3Ahmanson Translational Imaging Division, University of California, Los Angeles (UCLA), 4Crump Institute for Molecular Imaging, University of California, Los Angeles (UCLA)
* These authors contributed equally

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résumé
Automatic Translation

Positron-emission tomography (PET) imaging sites that are involved in multiple early clinical research trials need robust and versatile radiotracer manufacturing capabilities. Using the radiotracer [18F]Clofarabine as an example, we illustrate how to automate the synthesis of a radiotracer using a flexible, cassette-based radiosynthesizer and validate the synthesis for clinical use.

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Keywords: Automated Synthesis PET Tracer Fluorine-18 Clofarabine Radiosynthesizer Unit Operations Fluoride Evaporation Precursor Addition Fluorination Reaction Disposable Cassettes Reaction Vessels Reagent Vials
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