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JoVE Journal Bioengineering
Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants
 

Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants

Article DOI: 10.3791/58487-v • 08:42 min • January 7th, 2019
January 7th, 2019 •
1, 1, 1
1Department of Biomedical Engineering, University of Rochester

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We present a method to assess the spatial extent of cell injury/death on the articular surface of intact murine joints after application of controlled mechanical loads or impacts. This method can be used to investigate how osteoarthritis, genetic factors and/or different loading regimens affect the vulnerability of in situ chondrocytes.

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Real-time Visualization Analysis Chondrocyte Injury Mechanical Loading Intact Cartilage Explants Vulnerability Articular Chondrocytes Physical Forces Native Boundary Conditions Mouse Model Specific Genes Susceptibility Mechanical Injury Dissection Distal Femur Skin Incision Knee Joint Leg Muscles Quadriceps Muscle Tendon Unit Anterior Side Of Femoral Shaft Patella Patellar Tendon Hamstring Muscle Tendon Unit
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