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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
 

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Article DOI: 10.3791/60442-v • 09:34 min • February 6th, 2020
February 6th, 2020 •
1, 1, 2,3
1Department of Chemical Engineering, University of Michigan, 2Department of Chemical Engineering, Monash University, 3Department of Materials Science and Engineering, Monash University

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A protocol is presented for the synthesis of information-encoded peptoid oligomers and for the sequence-directed self-assembly of these peptoids into molecular ladders using amines and aldehydes as dynamic covalent reactant pairs and Lewis acidic rare-earth metal triflates as multi-role reagents.

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Information-directed Assembly Oligomeric Sequences Dynamic Covalent Interactions Nucleic Acids Interstrand Bond Strength Lewis Acid Bond Dissociation Bond Rearrangement Kinetic Trapping Limitations Covalent Organic Frameworks Defect Rates Biomaterial Tissue Interfaces Annealing Times Hybridizations Aldehyde Residues Amine Residues Solid Support Resin Synthesizer Reaction Vessel
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