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In Vivo Mouse Model of Spinal Implant Infection
 

In Vivo Mouse Model of Spinal Implant Infection

Article DOI: 10.3791/60560-v • 08:03 min • June 23rd, 2020
June 23rd, 2020 •
1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 3, 2, 2, 2, 2, 2, 1, 1, 1
1Department of Orthopaedic Surgery, University of California Los Angeles, 2David Geffen School of Medicine, University of California Los Angeles, 3University of South Carolina School of Medicine, University of South Carolina

Chapitres

résumé
Automatic Translation

The protocol describes a novel in vivo mouse model of spinal implant infection where a stainless-steel k-wire implant is infected with bioluminescent Staphylococcus aureus Xen36. Bacterial burden is monitored longitudinally with bioluminescent imaging and confirmed with colony forming unit counts after euthanasia.

Tags

Keywords: Spinal Implant Infection Mouse Model S. Aureus In Vivo Bacterial Burden Postoperative Infection Spinal Surgery Host Factors Implant Factors Therapeutic Factors Longitudinal Study
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