Waiting
Traitement de la connexion…

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Neuroscience / A Scalable Model to Study the Effects of…
JoVE Journal
Neuroscience

Un abonnement à JoVE est nécessaire pour afficher ce contenu. Connectez-vous ou commencez votre essai gratuit.

JoVE Journal Neuroscience
A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish
 

A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish

Article DOI: 10.3791/62709-v • 08:13 min • May 31st, 2021
May 31st, 2021 •
1,2,3, 1,2,3, 2,3, 1,2,3
1Department of Biological Sciences, University of Notre Dame, 2Center for Zebrafish Research, University of Notre Dame, 3Center for Stem Cells and Regenerative Medicine, University of Notre Dame

Chapitres

résumé
Automatic Translation

We modified the Marmarou weight drop model for adult zebrafish to examine a breadth of pathologies following blunt-force traumatic brain injury (TBI) and the mechanisms underlying subsequent neuronal regeneration. This blunt-force TBI model is scalable, induces a mild, moderate, or severe TBI, and recapitulates injury heterogeneity observed in human TBI.

Tags

Keywords: Zebrafish Blunt-force Injury Traumatic Brain Injury TBI Modeling Clay Steel Disc Ball Bearing Injury Severity Dissection Optic Nerve Parietal Plate
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter