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Bioengineering

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JoVE Journal Bioengineering
Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall
 

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

Article DOI: 10.3791/64122-v • 11:47 min • July 6th, 2022
July 6th, 2022 •
*1, *1, *1, 1, 2, 1, 1, 1, 1, 1, 1, 1, 1
1Department of Cardiac Surgery and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 2Institutes of Biomedical Sciences and the Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College, Fudan University
* These authors contributed equally

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résumé
Automatic Translation

Here, we developed a human aorta smooth muscle cell organ-on-a-chip model to replicate the in vivo biomechanical strain of smooth muscle cells in the human aortic wall.

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Human Aorta Smooth Muscle Cell Organ-On-A-Chip Biomechanical Strain Aortic Wall Drug Screening Personalized Medicine Aortic Diseases In Vitro Platform Pathogenesis Mieradilijiang Abudubat Poster Doctor Laboratory Washing Sterile Pbs Intima Adventitia Layers Media Layer Tissue Samples SMCM (Smooth Muscle Cell Medium) FBS (Fetal Bovine Serum) Penicillin Streptomycin Culture Bottle Sterile Dropper Culture Medium Incubator
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