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Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction
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Médecine
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Journal JoVE Médecine
Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction

Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction

DOI:
10.3791/64387-v

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05:48 min

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August 09, 2022

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,
1Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Department of Medicine,University of Pittsburgh, 2Department of Immunology,University of Pittsburgh, 3Department of Bioengineering, Swanson School of Engineering,University of Pittsburgh

Chapitres

  • 00:05Introduction
  • 00:35Preparation and Endotracheal Intubation of the Mice
  • 02:23Permanent Ligation of the Left Coronary Artery
  • 03:51Post-Operative Care
  • 04:22Results: A Reproducible and Clinically Relevant Myocardial Infarction Murine Model to Improve the Left Coronary Artery Ligation
  • 05:19Conclusion

Summary

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Traduction automatique

Presented here is a surgical procedure for permanent ligation of the left coronary artery in mice. This model can be used to investigate the pathophysiology and associated inflammatory response after myocardial infarction.

Tags

Keywords: Left Coronary Artery LigationSurgical Murine ModelMyocardial InfarctionMouse ModelMIAnesthesiaBuprenorphineIntubationVentilatorThoracotomyLeft VentricleLeft Coronary Artery

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