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Demonstration of the DNA Fiber Assay for Investigating DNA Damage and Repair Dynamics Induced by Nanoparticles
 

Demonstration of the DNA Fiber Assay for Investigating DNA Damage and Repair Dynamics Induced by Nanoparticles

Article DOI: 10.3791/64903-v • 13:09 min • March 3rd, 2023
March 3rd, 2023 •
1, 1,2, 1
1Department of Biomedical Sciences, University of Illinois College of Medicine Rockford, 2Department of Health Sciences Education, University of Illinois College of Medicine Rockford

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The methodology assists in the analysis of variation in DNA replication dynamics in the presence of nanoparticles. Different methodologies can be adopted based on the cytotoxicity level of the material of interest. In addition, a description of the image analysis is provided to help in DNA fiber analysis.

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Keywords: DNA Fiber Assay DNA Damage DNA Repair Nanoparticles DNA Replication Dynamics Chromatin Dynamics Therapeutic Agents Nanomedicine RAW 264.5 Macrophage Cells Iododeoxyuridine Chloro-iododeoxyuridine
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