Alessandro Lugli Institute of Pathology University of Bern Biography Publications Institution JoVE Articles Alessandro Lugli has not added a biography. If you are Alessandro Lugli and would like to personalize this page please email our Author Liaison for assistance. Publications Tumor Budding in Upper Gastrointestinal Carcinomas Frontiers in Oncology. 2014 | Pubmed ID: 25177546 Evaluation of Colon Cancer Histomorphology: a Comparison Between Formalin and PAXgene Tissue Fixation by an International Ring Trial Virchows Archiv : an International Journal of Pathology. Aug, 2014 | Pubmed ID: 25085759 Investigation of IL-23 (p19, P40) and IL-23R Identifies Nuclear Expression of IL-23 P19 As a Favorable Prognostic Factor in Colorectal Cancer: a Retrospective Multicenter Study of 675 Patients Oncotarget. Jul, 2014 | Pubmed ID: 25015728 Defined Morphological Criteria Allow Reliable Diagnosis of Colorectal Serrated Polyps and Predict Polyp Genetics Virchows Archiv : an International Journal of Pathology. Jun, 2014 | Pubmed ID: 24728704 CD8/CD45RO T-cell Infiltration in Endoscopic Biopsies of Colorectal Cancer Predicts Nodal Metastasis and Survival Journal of Translational Medicine. 2014 | Pubmed ID: 24679169 The Tumor Border Configuration of Colorectal Cancer As a Histomorphological Prognostic Indicator Frontiers in Oncology. 2014 | Pubmed ID: 24600585 HLA Class II Antigen Expression in Colorectal Carcinoma Tumors As a Favorable Prognostic Marker Neoplasia (New York, N.Y.). Jan, 2014 | Pubmed ID: 24563618 Possible Role of Cdx2 in the Serrated Pathway of Colorectal Cancer Characterized by BRAF Mutation, High-level CpG Island Methylator Phenotype and Mismatch Repair-deficiency International Journal of Cancer. Journal International Du Cancer. May, 2014 | Pubmed ID: 24166180 Towards the Introduction of the 'Immunoscore' in the Classification of Malignant Tumours The Journal of Pathology. Jan, 2014 | Pubmed ID: 24122236 The Apoptotic and Proliferation Rate of Tumour Budding Cells in Colorectal Cancer Outlines a Heterogeneous Population of Cells with Various Impacts on Clinical Outcome Histopathology. Mar, 2014 | Pubmed ID: 24111856 Loss of Raf-1 Kinase Inhibitor Protein (RKIP) is Strongly Associated with High-grade Tumor Budding and Correlates with an Aggressive Phenotype in Pancreatic Ductal Adenocarcinoma (PDAC) Journal of Translational Medicine. 2013 | Pubmed ID: 24330423 Loss of Cdx2 Expression in Primary Tumors and Lymph Node Metastases is Specific for Mismatch Repair-Deficiency in Colorectal Cancer Frontiers in Oncology. 2013 | Pubmed ID: 24130965 High Myeloperoxidase Positive Cell Infiltration in Colorectal Cancer is an Independent Favorable Prognostic Factor PloS One. 2013 | Pubmed ID: 23734221 Next-generation Tissue Microarray (ngTMA) Increases the Quality of Biomarker Studies: an Example Using CD3, CD8, and CD45RO in the Tumor Microenvironment of Six Different Solid Tumor Types Journal of Translational Medicine. 2013 | Pubmed ID: 23627766 Clinical Impact of Programmed Cell Death Ligand 1 Expression in Colorectal Cancer European Journal of Cancer (Oxford, England : 1990). Jun, 2013 | Pubmed ID: 23478000 The Additional Facet of Immunoscore: Immunoprofiling As a Possible Predictive Tool for Cancer Treatment Journal of Translational Medicine. 2013 | Pubmed ID: 23452415 Tumor Budding Score Based on 10 High-power Fields is a Promising Basis for a Standardized Prognostic Scoring System in Stage II Colorectal Cancer Human Pathology. May, 2013 | Pubmed ID: 23159156 Proposal for a 10-high-power-fields Scoring Method for the Assessment of Tumor Budding in Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Feb, 2013 | Pubmed ID: 23018875 Cancer Classification Using the Immunoscore: a Worldwide Task Force Journal of Translational Medicine. 2012 | Pubmed ID: 23034130 Characterization of CDKN2A(p16) Methylation and Impact in Colorectal Cancer: Systematic Analysis Using Pyrosequencing Journal of Translational Medicine. 2012 | Pubmed ID: 22925370 Role of Intra- and Peritumoral Budding in the Interdisciplinary Management of Rectal Cancer Patients International Journal of Surgical Oncology. 2012 | Pubmed ID: 22900161 The Impact of CpG Island Methylator Phenotype and Microsatellite Instability on Tumour Budding in Colorectal Cancer Histopathology. Nov, 2012 | Pubmed ID: 22803799 Diagnostic Reproducibility of Tumour Budding in Colorectal Cancer: a Multicentre, Multinational Study Using Virtual Microscopy Histopathology. Jul, 2012 | Pubmed ID: 22765314 Metastases and Primary Tumors Around Dental Implants: A Literature Review and Case Report of Peri-implant Pulmonary Metastasis Quintessence International (Berlin, Germany : 1985). Jul-Aug, 2012 | Pubmed ID: 22670251 Stratification and Prognostic Relevance of Jass's Molecular Classification of Colorectal Cancer Frontiers in Oncology. 2012 | Pubmed ID: 22655257 Intra-tumoral Budding in Preoperative Biopsy Specimens Predicts Lymph Node and Distant Metastasis in Patients with Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Jul, 2012 | Pubmed ID: 22481282 Standardization of Whole Slide Image Morphologic Assessment with Definition of a New Application: Digital Slide Dynamic Morphometry Journal of Pathology Informatics. 2011 | Pubmed ID: 22200031 Characterization of the Immunological Microenvironment of Tumour Buds and Its Impact on Prognosis in Mismatch Repair-proficient and -deficient Colorectal Cancers Histopathology. Sep, 2011 | Pubmed ID: 22034888 VEGFA Gene Locus (6p12) Amplification Identifies a Small but Highly Aggressive Subgroup of Colorectal Cancer [corrected] Patients Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Oct, 2011 | Pubmed ID: 21743435 Intratumoral Budding As a Potential Parameter of Tumor Progression in Mismatch Repair-proficient and Mismatch Repair-deficient Colorectal Cancer Patients Human Pathology. Dec, 2011 | Pubmed ID: 21664647 Systematic Analysis of Proteins from Different Signaling Pathways in the Tumor Center and the Invasive Front of Colorectal Cancer Human Pathology. Dec, 2011 | Pubmed ID: 21664646 Comprehensive Analysis of CpG Island Methylator Phenotype (CIMP)-high, -low, and -negative Colorectal Cancers Based on Protein Marker Expression and Molecular Features The Journal of Pathology. Nov, 2011 | Pubmed ID: 21660972 The Medical Mystery of Napoleon Bonaparte: an Interdisciplinary Exposé Advances in Anatomic Pathology. Mar, 2011 | Pubmed ID: 21326012 Co-overexpression of P21 and Ki-67 in Head and Neck Squamous Cell Carcinoma Relative to a Significantly Poor Prognosis Head & Neck. Feb, 2011 | Pubmed ID: 20848449 Tumor Infiltration by FcγRIII (CD16)+ Myeloid Cells is Associated with Improved Survival in Patients with Colorectal Carcinoma International Journal of Cancer. Journal International Du Cancer. Jun, 2011 | Pubmed ID: 20715106 Epithelial Mesenchymal Transition and Tumor Budding in Aggressive Colorectal Cancer: Tumor Budding As Oncotarget Oncotarget. Nov, 2010 | Pubmed ID: 21317460 TIA-1 Cytotoxic Granule-associated RNA Binding Protein Improves the Prognostic Performance of CD8 in Mismatch Repair-proficient Colorectal Cancer PloS One. 2010 | Pubmed ID: 21179245 Tumor Budding Predicts Response to Anti-EGFR Therapies in Metastatic Colorectal Cancer Patients World Journal of Gastroenterology : WJG. Oct, 2010 | Pubmed ID: 20939111 Systematic Assessment of Protein Phenotypes Characterizing High-grade Tumour Budding in Mismatch Repair-proficient Colorectal Cancer Histopathology. Aug, 2010 | Pubmed ID: 20716165 Expression of P16 in Lymph Node Metastases of Adjuvantly Treated Stage III Colorectal Cancer Patients Identifies Poor Prognostic Subgroups: a Retrospective Analysis of Biomarkers in Matched Primary Tumor and Lymph Node Metastases Cancer. Oct, 2010 | Pubmed ID: 20572035 Role of Tumor Size in the Pre-operative Management of Rectal Cancer Patients BMC Gastroenterology. 2010 | Pubmed ID: 20550703 The Loss of the CBX7 Gene Expression Represents an Adverse Prognostic Marker for Survival of Colon Carcinoma Patients European Journal of Cancer (Oxford, England : 1990). Aug, 2010 | Pubmed ID: 20542683 Archaeology Dig into the Duodenal Biopsy Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. Jul, 2010 | Pubmed ID: 20471923 Role of the VEGF Ligand to Receptor Ratio in the Progression of Mismatch Repair-proficient Colorectal Cancer BMC Cancer. 2010 | Pubmed ID: 20222950 Combined Analysis of Specific KRAS Mutation, BRAF and Microsatellite Instability Identifies Prognostic Subgroups of Sporadic and Hereditary Colorectal Cancer International Journal of Cancer. Journal International Du Cancer. Dec, 2010 | Pubmed ID: 20162668 ABCG5-positivity in Tumor Buds is an Indicator of Poor Prognosis in Node-negative Colorectal Cancer Patients World Journal of Gastroenterology : WJG. Feb, 2010 | Pubmed ID: 20135722 Clinicopathological and Protein Characterization of BRAF- and K-RAS-mutated Colorectal Cancer and Implications for Prognosis International Journal of Cancer. Journal International Du Cancer. Jul, 2010 | Pubmed ID: 19908233 High Frequency of Tumor-infiltrating FOXP3(+) Regulatory T Cells Predicts Improved Survival in Mismatch Repair-proficient Colorectal Cancer Patients International Journal of Cancer. Journal International Du Cancer. Jun, 2010 | Pubmed ID: 19856313 Urokinase-type Plasminogen Activator is a Marker of Aggressive Phenotype and an Independent Prognostic Factor in Mismatch Repair-proficient Colorectal Cancer Human Pathology. Jan, 2010 | Pubmed ID: 19740518 Is the Improved Prognosis of P16 Positive Oropharyngeal Squamous Cell Carcinoma Dependent of the Treatment Modality? International Journal of Cancer. Journal International Du Cancer. Mar, 2010 | Pubmed ID: 19697324 Invasive Front of Colorectal Cancer: Dynamic Interface of Pro-/anti-tumor Factors World Journal of Gastroenterology : WJG. Dec, 2009 | Pubmed ID: 20014453 Systematic Assessment of the Prognostic Impact of Membranous CD44v6 Protein Expression in Colorectal Cancer Histopathology. Nov, 2009 | Pubmed ID: 19912362 Combined Histomorphologic and Immunohistochemical Phenotype to Predict the Presence of Vascular Invasion in Colon Cancer Diseases of the Colon and Rectum. Jun, 2009 | Pubmed ID: 19581855 Tumor Border Configuration Added to TNM Staging Better Stratifies Stage II Colorectal Cancer Patients into Prognostic Subgroups Cancer. Sep, 2009 | Pubmed ID: 19517467 Is Immunohistochemical Epidermal Growth Factor Receptor Expression Overestimated As a Prognostic Factor in Head-neck Squamous Cell Carcinoma? A Retrospective Analysis Based on a Tissue Microarray of 365 Carcinomas Human Pathology. Oct, 2008 | Pubmed ID: 18620726 Differential Diagnostic and Functional Role of the Multi-marker Phenotype CDX2/CK20/CK7 in Colorectal Cancer Stratified by Mismatch Repair Status Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Nov, 2008 | Pubmed ID: 18587323 RHAMM, P21 Combined Phenotype Identifies Microsatellite Instability-high Colorectal Cancers with a Highly Adverse Prognosis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2008 | Pubmed ID: 18559599 Local Recurrence in Mismatch Repair-proficient Colon Cancer Predicted by an Infiltrative Tumor Border and Lack of CD8+ Tumor-infiltrating Lymphocytes Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2008 | Pubmed ID: 18559598 Chromosomal Instability in Gastric Mucosa-associated Lymphoid Tissue Lymphomas: a Fluorescent in Situ Hybridization Study Using a Tissue Microarray Approach Human Pathology. Apr, 2008 | Pubmed ID: 18234275 Node-negative Colorectal Cancer at High Risk of Distant Metastasis Identified by Combined Analysis of Lymph Node Status, Vascular Invasion, and Raf-1 Kinase Inhibitor Protein Expression Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2008 | Pubmed ID: 18172264 Multimarker Phenotype Predicts Adverse Survival in Patients with Lymph Node-negative Colorectal Cancer Cancer. Feb, 2008 | Pubmed ID: 18076013 Value of Staining Intensity in the Interpretation of Immunohistochemistry for Tumor Markers in Colorectal Cancer Virchows Archiv : an International Journal of Pathology. Oct, 2007 | Pubmed ID: 17674041 Loss of Raf-1 Kinase Inhibitor Protein Expression is Associated with Tumor Progression and Metastasis in Colorectal Cancer American Journal of Clinical Pathology. May, 2007 | Pubmed ID: 17439843 Close Association Between HER-2 Amplification and Overexpression in Human Tumors of Non-breast Origin Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Feb, 2007 | Pubmed ID: 17361205 Loss of APAF-1 Expression is Associated with Tumour Progression and Adverse Prognosis in Colorectal Cancer European Journal of Cancer (Oxford, England : 1990). Apr, 2007 | Pubmed ID: 17350821 Prognostic Significance of Mammalian Sterile20-like Kinase 1 in Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Mar, 2007 | Pubmed ID: 17277767 Differential Significance of Tumour Infiltrating Lymphocytes in Sporadic Mismatch Repair Deficient Versus Proficient Colorectal Cancers: a Potential Role for Dysregulation of the Transforming Growth Factor-beta Pathway European Journal of Cancer (Oxford, England : 1990). Feb, 2007 | Pubmed ID: 17223543 Napoleon Bonaparte's Gastric Cancer: a Clinicopathologic Approach to Staging, Pathogenesis, and Etiology Nature Clinical Practice. Gastroenterology & Hepatology. Jan, 2007 | Pubmed ID: 17203089 Selecting Immunohistochemical Cut-off Scores for Novel Biomarkers of Progression and Survival in Colorectal Cancer Journal of Clinical Pathology. Oct, 2007 | Pubmed ID: 17182662 Prognostic Value of Cell Cycle and Apoptosis Regulatory Proteins in Mismatch Repair-proficient Colorectal Cancer: a Tissue Microarray-based Approach American Journal of Clinical Pathology. Jan, 2007 | Pubmed ID: 17145638 Construction and Validation of a Bone Marrow Tissue Microarray Journal of Clinical Pathology. Jan, 2007 | Pubmed ID: 16698953 Role of the Mitogen-activated Protein Kinase and Phosphoinositide 3-kinase/AKT Pathways Downstream Molecules, Phosphorylated Extracellular Signal-regulated Kinase, and Phosphorylated AKT in Colorectal Cancer-a Tissue Microarray-based Approach Human Pathology. Aug, 2006 | Pubmed ID: 16867865 Overexpression of the Receptor for Hyaluronic Acid Mediated Motility is an Independent Adverse Prognostic Factor in Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Oct, 2006 | Pubmed ID: 16763611 Scoring of P53, VEGF, Bcl-2 and APAF-1 Immunohistochemistry and Interobserver Reliability in Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Sep, 2006 | Pubmed ID: 16741523 EphB2 Expression Across 138 Human Tumor Types in a Tissue Microarray: High Levels of Expression in Gastrointestinal Cancers Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2005 | Pubmed ID: 16166419 Patterns of Gene Amplification in Gastrointestinal Stromal Tumors (GIST) Laboratory Investigation; a Journal of Technical Methods and Pathology. Jul, 2005 | Pubmed ID: 15864317 Proposal of a Morphologic Bone Marrow Response Score for Imatinib Mesylate Treatment in Chronic Myelogenous Leukemia Human Pathology. Jan, 2005 | Pubmed ID: 15712187 Prevalence of KIT Expression in Human Tumors Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2004 | Pubmed ID: 15542802 Hepatocyte Paraffin 1 Expression in Human Normal and Neoplastic Tissues: Tissue Microarray Analysis on 3,940 Tissue Samples American Journal of Clinical Pathology. Nov, 2004 | Pubmed ID: 15491968 Nonsense-mediated Decay Microarray Analysis Identifies Mutations of EPHB2 in Human Prostate Cancer Nature Genetics. Sep, 2004 | Pubmed ID: 15300251 Frequent EpCam Protein Expression in Human Carcinomas Human Pathology. Jan, 2004 | Pubmed ID: 14745734 Macrofollicular Variant of Papillary Carcinoma of the Thyroid: a Histologic, Cytologic, and Immunohistochemical Study of 3 Cases and Review of the Literature Archives of Pathology & Laboratory Medicine. Jan, 2004 | Pubmed ID: 14692811 Expression of B-cell Markers in Classical Hodgkin Lymphoma: a Tissue Microarray Analysis of 330 Cases Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Nov, 2003 | Pubmed ID: 14614054 Calretinin Expression in Human Normal and Neoplastic Tissues: a Tissue Microarray Analysis on 5233 Tissue Samples Human Pathology. Oct, 2003 | Pubmed ID: 14608532 High-throughput Tissue Microarray Analysis of G1-cyclin Alterations in Classical Hodgkin's Lymphoma Indicates Overexpression of Cyclin E1 The Journal of Pathology. Feb, 2003 | Pubmed ID: 12533833 バイオマーカー研究のための次世代組織マイクロアレイ(ngTMA)プロトコル Inti Zlobec1, Guido Suter1, Aurel Perren1, Alessandro Lugli1 1Institute of Pathology, University of Bern JoVE 51893 Medicina
バイオマーカー研究のための次世代組織マイクロアレイ(ngTMA)プロトコル Inti Zlobec1, Guido Suter1, Aurel Perren1, Alessandro Lugli1 1Institute of Pathology, University of Bern JoVE 51893 Medicina