Inti Zlobec Institute of Pathology University of Bern Biography Publications Institution JoVE Articles Inti Zlobec has not added a biography. If you are Inti Zlobec and would like to personalize this page please email our Author Liaison for assistance. Publications Tumor Budding in Upper Gastrointestinal Carcinomas Frontiers in Oncology. 2014 | Pubmed ID: 25177546 Assessment of Tumor Regression of Esophageal Adenocarcinomas After Neoadjuvant Chemotherapy: Comparison of 2 Commonly Used Scoring Approaches The American Journal of Surgical Pathology. Aug, 2014 | Pubmed ID: 25140894 Investigation of IL-23 (p19, P40) and IL-23R Identifies Nuclear Expression of IL-23 P19 As a Favorable Prognostic Factor in Colorectal Cancer: a Retrospective Multicenter Study of 675 Patients Oncotarget. Jul, 2014 | Pubmed ID: 25015728 CD8/CD45RO T-cell Infiltration in Endoscopic Biopsies of Colorectal Cancer Predicts Nodal Metastasis and Survival Journal of Translational Medicine. 2014 | Pubmed ID: 24679169 Proper Paraffin Slide Storage is Crucial for Translational Research Projects Involving Immunohistochemistry Stains Clinical and Translational Medicine. 2014 | Pubmed ID: 24636624 HLA Class II Antigen Expression in Colorectal Carcinoma Tumors As a Favorable Prognostic Marker Neoplasia (New York, N.Y.). Jan, 2014 | Pubmed ID: 24563618 A Multifactorial Histopathologic Score for the Prediction of Prognosis of Resected Esophageal Adenocarcinomas After Neoadjuvant Chemotherapy Annals of Surgical Oncology. Mar, 2014 | Pubmed ID: 24281419 Possible Role of Cdx2 in the Serrated Pathway of Colorectal Cancer Characterized by BRAF Mutation, High-level CpG Island Methylator Phenotype and Mismatch Repair-deficiency International Journal of Cancer. Journal International Du Cancer. May, 2014 | Pubmed ID: 24166180 Towards the Introduction of the 'Immunoscore' in the Classification of Malignant Tumours The Journal of Pathology. Jan, 2014 | Pubmed ID: 24122236 The Apoptotic and Proliferation Rate of Tumour Budding Cells in Colorectal Cancer Outlines a Heterogeneous Population of Cells with Various Impacts on Clinical Outcome Histopathology. Mar, 2014 | Pubmed ID: 24111856 Loss of Raf-1 Kinase Inhibitor Protein (RKIP) is Strongly Associated with High-grade Tumor Budding and Correlates with an Aggressive Phenotype in Pancreatic Ductal Adenocarcinoma (PDAC) Journal of Translational Medicine. 2013 | Pubmed ID: 24330423 Neonatal Fc Receptor Expression in Dendritic Cells Mediates Protective Immunity Against Colorectal Cancer Immunity. Dec, 2013 | Pubmed ID: 24290911 Loss of Cdx2 Expression in Primary Tumors and Lymph Node Metastases is Specific for Mismatch Repair-Deficiency in Colorectal Cancer Frontiers in Oncology. 2013 | Pubmed ID: 24130965 ATG5 is Induced by DNA-damaging Agents and Promotes Mitotic Catastrophe Independent of Autophagy Nature Communications. 2013 | Pubmed ID: 23945651 The Growing Galectin Network in Colon Cancer and Clinical Relevance of Cytoplasmic Galectin-3 Reactivity Anticancer Research. Aug, 2013 | Pubmed ID: 23898060 High Myeloperoxidase Positive Cell Infiltration in Colorectal Cancer is an Independent Favorable Prognostic Factor PloS One. 2013 | Pubmed ID: 23734221 Next-generation Tissue Microarray (ngTMA) Increases the Quality of Biomarker Studies: an Example Using CD3, CD8, and CD45RO in the Tumor Microenvironment of Six Different Solid Tumor Types Journal of Translational Medicine. 2013 | Pubmed ID: 23627766 Estrogen Receptor β Expression and Androgen Receptor Phosphorylation Correlate with a Poor Clinical Outcome in Hormone-naive Prostate Cancer and Are Elevated in Castration-resistant Disease Endocrine-related Cancer. Jun, 2013 | Pubmed ID: 23580588 Novel Biomarkers for the Prediction of Metastasis in Colorectal Cancer Expert Opinion on Medical Diagnostics. Mar, 2013 | Pubmed ID: 23530884 Clinical Impact of Programmed Cell Death Ligand 1 Expression in Colorectal Cancer European Journal of Cancer (Oxford, England : 1990). Jun, 2013 | Pubmed ID: 23478000 Prediction of Outcome in Patients with Low-grade Squamous Intraepithelial Lesions by Fluorescence in Situ Hybridization Analysis of Human Papillomavirus, TERC, and MYC Cancer Cytopathology. Aug, 2013 | Pubmed ID: 23408758 Tumor Budding Score Based on 10 High-power Fields is a Promising Basis for a Standardized Prognostic Scoring System in Stage II Colorectal Cancer Human Pathology. May, 2013 | Pubmed ID: 23159156 Klf4 Transcription Factor is Expressed in the Cytoplasm of Prostate Cancer Cells European Journal of Cancer (Oxford, England : 1990). Mar, 2013 | Pubmed ID: 23089465 Proposal for a 10-high-power-fields Scoring Method for the Assessment of Tumor Budding in Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Feb, 2013 | Pubmed ID: 23018875 The Clinical Impact of P16 Status in Fine-needle Aspirates of Cervical Lymph Node Metastasis of Head and Neck Squamous Cell Carcinomas European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. Feb, 2013 | Pubmed ID: 22588195 Cancer Classification Using the Immunoscore: a Worldwide Task Force Journal of Translational Medicine. 2012 | Pubmed ID: 23034130 Characterization of CDKN2A(p16) Methylation and Impact in Colorectal Cancer: Systematic Analysis Using Pyrosequencing Journal of Translational Medicine. 2012 | Pubmed ID: 22925370 Role of Intra- and Peritumoral Budding in the Interdisciplinary Management of Rectal Cancer Patients International Journal of Surgical Oncology. 2012 | Pubmed ID: 22900161 乳癌における KCNMA1 の役割。 PloS One. 2012 | Pubmed ID: 22899999 Prognostic Impact of β-2-microglobulin Expression in Colorectal Cancers Stratified by Mismatch Repair Status Journal of Clinical Pathology. Nov, 2012 | Pubmed ID: 22859396 The Impact of CpG Island Methylator Phenotype and Microsatellite Instability on Tumour Budding in Colorectal Cancer Histopathology. Nov, 2012 | Pubmed ID: 22803799 Diagnostic Reproducibility of Tumour Budding in Colorectal Cancer: a Multicentre, Multinational Study Using Virtual Microscopy Histopathology. Jul, 2012 | Pubmed ID: 22765314 Stratification and Prognostic Relevance of Jass's Molecular Classification of Colorectal Cancer Frontiers in Oncology. 2012 | Pubmed ID: 22655257 Intra-tumoral Budding in Preoperative Biopsy Specimens Predicts Lymph Node and Distant Metastasis in Patients with Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Jul, 2012 | Pubmed ID: 22481282 Differential Pattern and Prognostic Significance of CD4+, FOXP3+ and IL-17+ Tumor Infiltrating Lymphocytes in Ductal and Lobular Breast Cancers BMC Cancer. 2012 | Pubmed ID: 22471961 HMGA1 and HMGA2 Protein Expression Correlates with Advanced Tumour Grade and Lymph Node Metastasis in Pancreatic Adenocarcinoma Histopathology. Feb, 2012 | Pubmed ID: 22276603 Effect of EpCAM, CD44, CD133 and CD166 Expression on Patient Survival in Tumours of the Ampulla of Vater Journal of Clinical Pathology. Feb, 2012 | Pubmed ID: 22130902 Immunophenotyping Analysis in Invasive Micropapillary Carcinoma of the Breast: Role of CD24 and CD44 Isoforms Expression Breast (Edinburgh, Scotland). Apr, 2012 | Pubmed ID: 22014860 Standardization of Whole Slide Image Morphologic Assessment with Definition of a New Application: Digital Slide Dynamic Morphometry Journal of Pathology Informatics. 2011 | Pubmed ID: 22200031 Characterization of the Immunological Microenvironment of Tumour Buds and Its Impact on Prognosis in Mismatch Repair-proficient and -deficient Colorectal Cancers Histopathology. Sep, 2011 | Pubmed ID: 22034888 VEGFA Gene Locus (6p12) Amplification Identifies a Small but Highly Aggressive Subgroup of Colorectal Cancer [corrected] Patients Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Oct, 2011 | Pubmed ID: 21743435 Prognostic Significance of CD8+ T Lymphocytes in Breast Cancer Depends Upon Both Oestrogen Receptor Status and Histological Grade Histopathology. Jun, 2011 | Pubmed ID: 21707712 Intratumoral Budding As a Potential Parameter of Tumor Progression in Mismatch Repair-proficient and Mismatch Repair-deficient Colorectal Cancer Patients Human Pathology. Dec, 2011 | Pubmed ID: 21664647 Systematic Analysis of Proteins from Different Signaling Pathways in the Tumor Center and the Invasive Front of Colorectal Cancer Human Pathology. Dec, 2011 | Pubmed ID: 21664646 Comprehensive Analysis of CpG Island Methylator Phenotype (CIMP)-high, -low, and -negative Colorectal Cancers Based on Protein Marker Expression and Molecular Features The Journal of Pathology. Nov, 2011 | Pubmed ID: 21660972 High CD10 Expression in Lymph Node Metastases from Surgically Treated Prostate Cancer Independently Predicts Early Death Virchows Archiv : an International Journal of Pathology. Jun, 2011 | Pubmed ID: 21538124 Assessing Downgrading of Locally Advanced Rectal Cancer After Chemo-radiotherapy European Journal of Cancer (Oxford, England : 1990). May, 2011 | Pubmed ID: 21439814 High-level Cytoplasmic Cyclin D1 Expression in Lymph Node Metastases from Prostate Cancer Independently Predicts Early Biochemical Failure and Death in Surgically Treated Patients Histopathology. Apr, 2011 | Pubmed ID: 21438905 Deletion of the Inhibitor of Growth 4 (ING4) Tumor Suppressor Gene is Prevalent in Human Epidermal Growth Factor 2 (HER2)-positive Breast Cancer Human Pathology. Jul, 2011 | Pubmed ID: 21315418 Can Molecular Markers Stratify the Diagnostic Value of High-grade Prostatic Intraepithelial Neoplasia? Human Pathology. May, 2011 | Pubmed ID: 21237492 Co-overexpression of P21 and Ki-67 in Head and Neck Squamous Cell Carcinoma Relative to a Significantly Poor Prognosis Head & Neck. Feb, 2011 | Pubmed ID: 20848449 Tumor Infiltration by FcγRIII (CD16)+ Myeloid Cells is Associated with Improved Survival in Patients with Colorectal Carcinoma International Journal of Cancer. Journal International Du Cancer. Jun, 2011 | Pubmed ID: 20715106 Epithelial Mesenchymal Transition and Tumor Budding in Aggressive Colorectal Cancer: Tumor Budding As Oncotarget Oncotarget. Nov, 2010 | Pubmed ID: 21317460 TIA-1 Cytotoxic Granule-associated RNA Binding Protein Improves the Prognostic Performance of CD8 in Mismatch Repair-proficient Colorectal Cancer PloS One. 2010 | Pubmed ID: 21179245 Tumor Budding Predicts Response to Anti-EGFR Therapies in Metastatic Colorectal Cancer Patients World Journal of Gastroenterology : WJG. Oct, 2010 | Pubmed ID: 20939111 Systematic Assessment of Protein Phenotypes Characterizing High-grade Tumour Budding in Mismatch Repair-proficient Colorectal Cancer Histopathology. Aug, 2010 | Pubmed ID: 20716165 Expression of P16 in Lymph Node Metastases of Adjuvantly Treated Stage III Colorectal Cancer Patients Identifies Poor Prognostic Subgroups: a Retrospective Analysis of Biomarkers in Matched Primary Tumor and Lymph Node Metastases Cancer. Oct, 2010 | Pubmed ID: 20572035 Role of Tumor Size in the Pre-operative Management of Rectal Cancer Patients BMC Gastroenterology. 2010 | Pubmed ID: 20550703 The Loss of the CBX7 Gene Expression Represents an Adverse Prognostic Marker for Survival of Colon Carcinoma Patients European Journal of Cancer (Oxford, England : 1990). Aug, 2010 | Pubmed ID: 20542683 Differential Cell Cycle and Proliferation Marker Expression in Ductal Pancreatic Adenocarcinoma and Pancreatic Intraepithelial Neoplasia (PanIN) Pathology. Apr, 2010 | Pubmed ID: 20350215 Role of the VEGF Ligand to Receptor Ratio in the Progression of Mismatch Repair-proficient Colorectal Cancer BMC Cancer. 2010 | Pubmed ID: 20222950 Loss of the CBX7 Protein Expression Correlates with a More Aggressive Phenotype in Pancreatic Cancer European Journal of Cancer (Oxford, England : 1990). May, 2010 | Pubmed ID: 20185297 Combined Analysis of Specific KRAS Mutation, BRAF and Microsatellite Instability Identifies Prognostic Subgroups of Sporadic and Hereditary Colorectal Cancer International Journal of Cancer. Journal International Du Cancer. Dec, 2010 | Pubmed ID: 20162668 Fluorescence in Situ Hybridization in the Definitive Diagnosis of Malignant Mesothelioma in Effusion Cytology Chest. Jul, 2010 | Pubmed ID: 20139227 ABCG5-positivity in Tumor Buds is an Indicator of Poor Prognosis in Node-negative Colorectal Cancer Patients World Journal of Gastroenterology : WJG. Feb, 2010 | Pubmed ID: 20135722 BOB.1, CD79a and Cyclin E Are the Most Appropriate Markers to Discriminate Classical Hodgkin's Lymphoma from Primary Mediastinal Large B-cell Lymphoma Histopathology. Jan, 2010 | Pubmed ID: 20102401 Prognostic Immunophenotypic Biomarker Studies in Diffuse Large B Cell Lymphoma with Special Emphasis on Rational Determination of Cut-off Scores Leukemia & Lymphoma. Feb, 2010 | Pubmed ID: 19925052 Clinicopathological and Protein Characterization of BRAF- and K-RAS-mutated Colorectal Cancer and Implications for Prognosis International Journal of Cancer. Journal International Du Cancer. Jul, 2010 | Pubmed ID: 19908233 High Frequency of Tumor-infiltrating FOXP3(+) Regulatory T Cells Predicts Improved Survival in Mismatch Repair-proficient Colorectal Cancer Patients International Journal of Cancer. Journal International Du Cancer. Jun, 2010 | Pubmed ID: 19856313 Urokinase-type Plasminogen Activator is a Marker of Aggressive Phenotype and an Independent Prognostic Factor in Mismatch Repair-proficient Colorectal Cancer Human Pathology. Jan, 2010 | Pubmed ID: 19740518 Is the Improved Prognosis of P16 Positive Oropharyngeal Squamous Cell Carcinoma Dependent of the Treatment Modality? International Journal of Cancer. Journal International Du Cancer. Mar, 2010 | Pubmed ID: 19697324 Assessment of Mean EGFR Gene Copy Number is a Highly Reproducible Method for Evaluating FISH in Histological and Cytological Cancer Specimens Lung Cancer (Amsterdam, Netherlands). May, 2010 | Pubmed ID: 19616866 Invasive Front of Colorectal Cancer: Dynamic Interface of Pro-/anti-tumor Factors World Journal of Gastroenterology : WJG. Dec, 2009 | Pubmed ID: 20014453 Systematic Assessment of the Prognostic Impact of Membranous CD44v6 Protein Expression in Colorectal Cancer Histopathology. Nov, 2009 | Pubmed ID: 19912362 Combined Histomorphologic and Immunohistochemical Phenotype to Predict the Presence of Vascular Invasion in Colon Cancer Diseases of the Colon and Rectum. Jun, 2009 | Pubmed ID: 19581855 Tumor Border Configuration Added to TNM Staging Better Stratifies Stage II Colorectal Cancer Patients into Prognostic Subgroups Cancer. Sep, 2009 | Pubmed ID: 19517467 HOX D13 Expression Across 79 Tumor Tissue Types International Journal of Cancer. Journal International Du Cancer. Oct, 2009 | Pubmed ID: 19488988 The Prognostic Value of Cytology and Fluorescence in Situ Hybridization in the Follow-up of Nonmuscle-invasive Bladder Cancer After Intravesical Bacillus Calmette-Guérin Therapy International Journal of Cancer. Journal International Du Cancer. Jun, 2009 | Pubmed ID: 19230026 Tumour Growth Fraction Measured by Immunohistochemical Staining of Ki67 is an Independent Prognostic Factor in Preoperative Prostate Biopsies with Small-volume or Low-grade Prostate Cancer International Journal of Cancer. Journal International Du Cancer. May, 2009 | Pubmed ID: 19117060 Expression of CD24, P-cadherin and S100A4 in Tumors of the Ampulla of Vater Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Feb, 2009 | Pubmed ID: 19043399 Immunophenotyping and Oncogene Amplifications in Tumors of the Papilla of Vater Virchows Archiv : an International Journal of Pathology. Dec, 2008 | Pubmed ID: 18936968 Clinical Significance of Cell Cycle- and Apoptosis-related Markers in Biliary Tract Cancer: a Tissue Microarray-based Approach Revealing a Distinctive Immunophenotype for Intrahepatic and Extrahepatic Cholangiocarcinomas American Journal of Clinical Pathology. Nov, 2008 | Pubmed ID: 18854271 Is Immunohistochemical Epidermal Growth Factor Receptor Expression Overestimated As a Prognostic Factor in Head-neck Squamous Cell Carcinoma? A Retrospective Analysis Based on a Tissue Microarray of 365 Carcinomas Human Pathology. Oct, 2008 | Pubmed ID: 18620726 Differential Diagnostic and Functional Role of the Multi-marker Phenotype CDX2/CK20/CK7 in Colorectal Cancer Stratified by Mismatch Repair Status Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Nov, 2008 | Pubmed ID: 18587323 RHAMM, P21 Combined Phenotype Identifies Microsatellite Instability-high Colorectal Cancers with a Highly Adverse Prognosis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2008 | Pubmed ID: 18559599 Local Recurrence in Mismatch Repair-proficient Colon Cancer Predicted by an Infiltrative Tumor Border and Lack of CD8+ Tumor-infiltrating Lymphocytes Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2008 | Pubmed ID: 18559598 KIT, PDGFRalpha and EGFR Analysis in Nephroblastoma Virchows Archiv : an International Journal of Pathology. Jun, 2008 | Pubmed ID: 18478259 Node-negative Colorectal Cancer at High Risk of Distant Metastasis Identified by Combined Analysis of Lymph Node Status, Vascular Invasion, and Raf-1 Kinase Inhibitor Protein Expression Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2008 | Pubmed ID: 18172264 Multimarker Phenotype Predicts Adverse Survival in Patients with Lymph Node-negative Colorectal Cancer Cancer. Feb, 2008 | Pubmed ID: 18076013 Value of Staining Intensity in the Interpretation of Immunohistochemistry for Tumor Markers in Colorectal Cancer Virchows Archiv : an International Journal of Pathology. Oct, 2007 | Pubmed ID: 17674041 HER2 Gene Status in Primary Breast Cancers and Matched Distant Metastases Breast Cancer Research : BCR. 2007 | Pubmed ID: 17511881 Loss of Raf-1 Kinase Inhibitor Protein Expression is Associated with Tumor Progression and Metastasis in Colorectal Cancer American Journal of Clinical Pathology. May, 2007 | Pubmed ID: 17439843 Loss of APAF-1 Expression is Associated with Tumour Progression and Adverse Prognosis in Colorectal Cancer European Journal of Cancer (Oxford, England : 1990). Apr, 2007 | Pubmed ID: 17350821 Prognostic Significance of Mammalian Sterile20-like Kinase 1 in Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Mar, 2007 | Pubmed ID: 17277767 Differential Significance of Tumour Infiltrating Lymphocytes in Sporadic Mismatch Repair Deficient Versus Proficient Colorectal Cancers: a Potential Role for Dysregulation of the Transforming Growth Factor-beta Pathway European Journal of Cancer (Oxford, England : 1990). Feb, 2007 | Pubmed ID: 17223543 Napoleon Bonaparte's Gastric Cancer: a Clinicopathologic Approach to Staging, Pathogenesis, and Etiology Nature Clinical Practice. Gastroenterology & Hepatology. Jan, 2007 | Pubmed ID: 17203089 Selecting Immunohistochemical Cut-off Scores for Novel Biomarkers of Progression and Survival in Colorectal Cancer Journal of Clinical Pathology. Oct, 2007 | Pubmed ID: 17182662 Prognostic Value of Cell Cycle and Apoptosis Regulatory Proteins in Mismatch Repair-proficient Colorectal Cancer: a Tissue Microarray-based Approach American Journal of Clinical Pathology. Jan, 2007 | Pubmed ID: 17145638 Role of the Mitogen-activated Protein Kinase and Phosphoinositide 3-kinase/AKT Pathways Downstream Molecules, Phosphorylated Extracellular Signal-regulated Kinase, and Phosphorylated AKT in Colorectal Cancer-a Tissue Microarray-based Approach Human Pathology. Aug, 2006 | Pubmed ID: 16867865 Overexpression of the Receptor for Hyaluronic Acid Mediated Motility is an Independent Adverse Prognostic Factor in Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Oct, 2006 | Pubmed ID: 16763611 Scoring of P53, VEGF, Bcl-2 and APAF-1 Immunohistochemistry and Interobserver Reliability in Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Sep, 2006 | Pubmed ID: 16741523 The Predictive Value of Apoptosis Protease-activating Factor 1 in Rectal Tumors Treated with Preoperative, High-dose-rate Brachytherapy Cancer. Jan, 2006 | Pubmed ID: 16315248 VEGF As a Predictive Marker of Rectal Tumor Response to Preoperative Radiotherapy Cancer. Dec, 2005 | Pubmed ID: 16222693 A Predictive Model of Rectal Tumor Response to Preoperative Radiotherapy Using Classification and Regression Tree Methods Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2005 | Pubmed ID: 16061859 バイオマーカー研究のための次世代組織マイクロアレイ(ngTMA)プロトコル Inti Zlobec1, Guido Suter1, Aurel Perren1, Alessandro Lugli1 1Institute of Pathology, University of Bern JoVE 51893 Medicina
バイオマーカー研究のための次世代組織マイクロアレイ(ngTMA)プロトコル Inti Zlobec1, Guido Suter1, Aurel Perren1, Alessandro Lugli1 1Institute of Pathology, University of Bern JoVE 51893 Medicina