Nai-Kong V. Cheung Department of Pediatrics Memorial Sloan Kettering Cancer Center Biography Publications Institution JoVE Articles Nai-Kong V. Cheung has not added a biography. If you are Nai-Kong V. Cheung and would like to personalize this page please email our Author Liaison for assistance. Publications Clonal Evolution During Metastatic Spread in High-risk Neuroblastoma Nature Genetics. May, 2023 | Pubmed ID: 37169874 Identification of Immunotherapy and Radioimmunotherapy Targets on Desmoplastic Small Round Cell Tumors Frontiers in Oncology. 2023 | Pubmed ID: 37091153 Targeting Tumor Vasculature to Improve Antitumor Activity of T Cells Armed Ex Vivo with T Cell Engaging Bispecific Antibody Journal for Immunotherapy of Cancer. Mar, 2023 | Pubmed ID: 36990507 Clinical Outcomes of Pediatric Patients Receiving Multimodality Treatment of Second Central Nervous System Relapse of Neuroblastoma Pediatric Blood & Cancer. Feb, 2023 | Pubmed ID: 36349892 Immunotherapy with Anti-G Monoclonal Antibody in Infants with High-risk Neuroblastoma International Journal of Cancer. Jan, 2023 | Pubmed ID: 35913764 Skeletal Muscle Metastases in Neuroblastoma Share Common Progenitors with Primary Tumor and Biologically Resemble Stage MS Disease Frontiers in Oncology. 2022 | Pubmed ID: 36686814 Desmoplastic Small Round Cell Tumor Cancer Stem Cell-like Cells Resist Chemotherapy but Remain Dependent on the EWSR1-WT1 Oncoprotein Frontiers in Cell and Developmental Biology. 2022 | Pubmed ID: 36506091 Phase 1 Study of Intraventricular I-omburtamab Targeting B7H3 (CD276)-expressing CNS Malignancies Journal of Hematology & Oncology. Nov, 2022 | Pubmed ID: 36371226 Pretargeting: A Path Forward for Radioimmunotherapy Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Sep, 2022 | Pubmed ID: 36215514 Connecting Telomere Maintenance and Regulation to the Developmental Origin and Differentiation States of Neuroblastoma Tumor Cells Journal of Hematology & Oncology. Aug, 2022 | Pubmed ID: 36030273 Bispecific Antibodies for the Treatment of Neuroblastoma Pharmacology & Therapeutics. Sep, 2022 | Pubmed ID: 35830901 Overcoming Tumor Heterogeneity by Ex Vivo Arming of T Cells Using Multiple Bispecific Antibodies Journal for Immunotherapy of Cancer. Jan, 2022 | Pubmed ID: 35086947 Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones That Predict Therapy-Related Leukemia Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2022 | Pubmed ID: 35078859 Intraperitoneal Pretargeted Radioimmunotherapy for Colorectal Peritoneal Carcinomatosis Molecular Cancer Therapeutics. Jan, 2022 | Pubmed ID: 34667111 KMT2A-MAML2 Rearrangement Emerged and Regressed During Neuroblastoma Therapy Without Leukemia After 12.8-year Follow-up Pediatric Blood & Cancer. Jan, 2022 | Pubmed ID: 34550633 Influence of Fc Modifications and IgG Subclass on Biodistribution of Humanized Antibodies Targeting L1CAM Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Apr, 2022 | Pubmed ID: 34353869 Ganglioside GD2 Enhances the Malignant Phenotypes of Melanoma Cells by Cooperating with Integrins International Journal of Molecular Sciences. Dec, 2021 | Pubmed ID: 35008849 Phase I Trial of Oral Yeast-Derived β-Glucan to Enhance Anti-GD2 Immunotherapy of Resistant High-Risk Neuroblastoma Cancers. Dec, 2021 | Pubmed ID: 34944886 Immunotherapy and Radioimmunotherapy for Desmoplastic Small Round Cell Tumor Frontiers in Oncology. 2021 | Pubmed ID: 34869013 Reciprocal Impacts of Telomerase Activity and ADRN/MES Differentiation State in Neuroblastoma Tumor Biology Communications Biology. Nov, 2021 | Pubmed ID: 34799676 Human Cytomegalovirus Infection Promotes Expansion of a Functionally Superior Cytoplasmic CD3 NK Cell Subset with a Bcl11b-Regulated T Cell Signature Journal of Immunology (Baltimore, Md. : 1950). Nov, 2021 | Pubmed ID: 34625521 Novel Potent Anti-STEAP1 Bispecific Antibody to Redirect T Cells for Cancer Immunotherapy Journal for Immunotherapy of Cancer. Sep, 2021 | Pubmed ID: 34497115 Modulating Tumor Infiltrating Myeloid Cells to Enhance Bispecific Antibody-driven T Cell Infiltration and Anti-tumor Response Journal of Hematology & Oncology. Sep, 2021 | Pubmed ID: 34496935 T Cell Engaging Bispecific Antibodies Targeting CD33 IgV and IgC Domains for the Treatment of Acute Myeloid Leukemia Journal for Immunotherapy of Cancer. May, 2021 | Pubmed ID: 34035113 Potent Ex Vivo Armed T Cells Using Recombinant Bispecific Antibodies for Adoptive Immunotherapy with Reduced Cytokine Release Journal for Immunotherapy of Cancer. May, 2021 | Pubmed ID: 33986124 Potent Antitumor Effect of T Cells Armed with Anti-GD2 Bispecific Antibody Pediatric Blood & Cancer. Jul, 2021 | Pubmed ID: 33844437 Engineered Cells As a Test Platform for Radiohaptens in Pretargeted Imaging and Radioimmunotherapy Applications Bioconjugate Chemistry. Apr, 2021 | Pubmed ID: 33819023 A Novel Multimeric IL15/IL15Rα-Fc Complex to Enhance Cancer Immunotherapy Oncoimmunology. Mar, 2021 | Pubmed ID: 33763293 Survival Impact of Anti-GD2 Antibody Response in a Phase II Ganglioside Vaccine Trial Among Patients With High-Risk Neuroblastoma With Prior Disease Progression Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jan, 2021 | Pubmed ID: 33326254 IntraOmmaya Compartmental Radioimmunotherapy Using I-omburtamab-pharmacokinetic Modeling to Optimize Therapeutic Index European Journal of Nuclear Medicine and Molecular Imaging. Apr, 2021 | Pubmed ID: 33047248 A Self-Assembling and Disassembling (SADA) Bispecific Antibody (BsAb) Platform for Curative Two-step Pretargeted Radioimmunotherapy Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2021 | Pubmed ID: 32958698 Editorial: Bispecific Antibodies for T-Cell Based Immunotherapy Frontiers in Oncology. 2020 | Pubmed ID: 33363043 GD2 or HER2 Targeting T Cell Engaging Bispecific Antibodies to Treat Osteosarcoma Journal of Hematology & Oncology. Dec, 2020 | Pubmed ID: 33303017 Overcoming Leukemia Heterogeneity by Combining T Cell Engaging Bispecific Antibodies Journal for Immunotherapy of Cancer. Nov, 2020 | Pubmed ID: 33239418 B7H3-Directed Intraperitoneal Radioimmunotherapy With Radioiodinated Omburtamab for Desmoplastic Small Round Cell Tumor and Other Peritoneal Tumors: Results of a Phase I Study Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2020 | Pubmed ID: 33119478 Cancer Immunotherapy Via Targeted TGF-β Signalling Blockade in T Cells Nature. Nov, 2020 | Pubmed ID: 33087933 Pan-neuroblastoma Analysis Reveals Age- and Signature-associated Driver Alterations Nature Communications. Oct, 2020 | Pubmed ID: 33056981 Alpha Radioimmunotherapy Using Ac-proteus-DOTA for Solid Tumors - Safety at Curative Doses Theranostics. 2020 | Pubmed ID: 33052220 Reduced-dose Craniospinal Irradiation for Central Nervous System Relapsed Neuroblastoma Pediatric Blood & Cancer. Sep, 2020 | Pubmed ID: 32608559 Targets and Antibody Formats for Immunotherapy of Neuroblastoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jun, 2020 | Pubmed ID: 32167865 Interdomain Spacing and Spatial Configuration Drive the Potency of IgG-[L]-scFv T Cell Bispecific Antibodies Science Translational Medicine. Mar, 2020 | Pubmed ID: 32161106 Immunotherapy of Pediatric Solid Tumors: Treatments at a Crossroads, with an Emphasis on Antibodies Cancer Immunology Research. Feb, 2020 | Pubmed ID: 32015013 An -Acetylgalactosamino Dendron-Clearing Agent for High-Therapeutic-Index DOTA-Hapten Pretargeted Radioimmunotherapy Bioconjugate Chemistry. Mar, 2020 | Pubmed ID: 31891487 ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition Via Modulation of Neuronal Gene Signatures Cancer Cell. Nov, 2019 | Pubmed ID: 31631027 Silencing Fc Domains in T Cell-Engaging Bispecific Antibodies Improves T-cell Trafficking and Antitumor Potency Cancer Immunology Research. Dec, 2019 | Pubmed ID: 31615814 Biodistribution and Dosimetry of Intraventricularly Administered I-Omburtamab in Patients with Metastatic Leptomeningeal Tumors Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Dec, 2019 | Pubmed ID: 31405921 Exploiting Signaling Pathways and Immune Targets Beyond the Standard of Care for Ewing Sarcoma Frontiers in Oncology. 2019 | Pubmed ID: 31275859 Telomere Trimming and DNA Damage As Signatures of High Risk Neuroblastoma Neoplasia (New York, N.Y.). Jul, 2019 | Pubmed ID: 31128432 Targeted Radioimmunotherapy for Embryonal Tumor with Multilayered Rosettes Journal of Neuro-oncology. May, 2019 | Pubmed ID: 30879172 Reduced-Dose Radiation Therapy to the Primary Site is Effective for High-Risk Neuroblastoma: Results From a Prospective Trial International Journal of Radiation Oncology, Biology, Physics. Jun, 2019 | Pubmed ID: 30763661 Theranostic Pretargeted Radioimmunotherapy of Internalizing Solid Tumor Antigens in Human Tumor Xenografts in Mice: Curative Treatment of HER2-positive Breast Carcinoma Theranostics. 2018 | Pubmed ID: 30429889 Adoptive Immunotherapy with Haploidentical Natural Killer Cells and Anti-GD2 Monoclonal Antibody M3F8 for Resistant Neuroblastoma: Results of a Phase I Study Oncoimmunology. 2018 | Pubmed ID: 30221057 Development of a Tetravalent Anti-GPA33/Anti-CD3 Bispecific Antibody for Colorectal Cancers Molecular Cancer Therapeutics. Oct, 2018 | Pubmed ID: 30082472 Convection-enhanced Delivery for Diffuse Intrinsic Pontine Glioma: a Single-centre, Dose-escalation, Phase 1 Trial The Lancet. Oncology. Aug, 2018 | Pubmed ID: 29914796 A Potent Tetravalent T-cell-engaging Bispecific Antibody Against CD33 in Acute Myeloid Leukemia Blood Advances. Jun, 2018 | Pubmed ID: 29858209 Treatment and Outcome of Adult-onset Neuroblastoma International Journal of Cancer. Sep, 2018 | Pubmed ID: 29574715 Dose-escalation is Needed for Gross Disease in High-risk Neuroblastoma Pediatric Blood & Cancer. Jul, 2018 | Pubmed ID: 29469198 TCR-mimic Bispecific Antibodies Targeting LMP2A Show Potent Activity Against EBV Malignancies JCI Insight. Feb, 2018 | Pubmed ID: 29467338 Radiation Therapy to Sites of Metastatic Disease As Part of Consolidation in High-Risk Neuroblastoma: Can Long-term Control Be Achieved? International Journal of Radiation Oncology, Biology, Physics. Apr, 2018 | Pubmed ID: 29439882 Genotyping Natural Killer Immune Checkpoints to Discover Biomarkers of Response Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2018 | Pubmed ID: 29122934 Targeting Intracellular Antigens with PMHC-Binding Antibodies: A Phage Display Approach Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29116509 A Phase II Study of Radioimmunotherapy with Intraventricular I-3F8 for Medulloblastoma Pediatric Blood & Cancer. Jan, 2018 | Pubmed ID: 28940863 T Cell Engaging Bispecific Antibody (T-BsAb): From Technology to Therapeutics Pharmacology & Therapeutics. Feb, 2018 | Pubmed ID: 28834699 -amplified Stage 2/3 Neuroblastoma: Excellent Survival in the Era of Anti-G Immunotherapy Oncotarget. Nov, 2017 | Pubmed ID: 29221128 Phase I Trial of Anti-GD2 Monoclonal Antibody Hu3F8 Plus GM-CSF: Impact of Body Weight, Immunogenicity and Anti-GD2 Response on Pharmacokinetics and Survival Oncoimmunology. 2017 | Pubmed ID: 29147617 Erratum to 'Limitations and Opportunities for Immune Checkpoint Inhibitors in Pediatric Malignancies' [Cancer Treat. Rev. 58C (2017) 22-33] Cancer Treatment Reviews. Nov, 2017 | Pubmed ID: 29033261 Curative Multicycle Radioimmunotherapy Monitored by Quantitative SPECT/CT-Based Theranostics, Using Bispecific Antibody Pretargeting Strategy in Colorectal Cancer Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Nov, 2017 | Pubmed ID: 28705917 Bispecific Antibody Does Not Induce T-cell Death Mediated by Chimeric Antigen Receptor Against Disialoganglioside GD2 Oncoimmunology. 2017 | Pubmed ID: 28680755 Limitations and Opportunities for Immune Checkpoint Inhibitors in Pediatric Malignancies Cancer Treatment Reviews. Jul, 2017 | Pubmed ID: 28622628 A Phase I Study of Single-agent Perifosine for Recurrent or Refractory Pediatric CNS and Solid Tumors PloS One. 2017 | Pubmed ID: 28582410 Immunotherapy of Hepatocellular Carcinoma Using Chimeric Antigen Receptors and Bispecific Antibodies Cancer Letters. Jul, 2017 | Pubmed ID: 28428075 Targeted Drug Distribution in Tumor Extracellular Fluid of GD2-expressing Neuroblastoma Patient-derived Xenografts Using SN-38-loaded Nanoparticles Conjugated to the Monoclonal Antibody 3F8 Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2017 | Pubmed ID: 28412222 Overcoming Resistance to HER2-targeted Therapy with a Novel HER2/CD3 Bispecific Antibody Oncoimmunology. 2017 | Pubmed ID: 28405494 Combination of Bevacizumab, Irinotecan, and Temozolomide for Refractory or Relapsed Neuroblastoma: Results of a Phase II Study Pediatric Blood & Cancer. Aug, 2017 | Pubmed ID: 28111925 A Phase I/Ib Trial Targeting the Pi3k/Akt Pathway Using Perifosine: Long-term Progression-free Survival of Patients with Resistant Neuroblastoma International Journal of Cancer. Jan, 2017 | Pubmed ID: 27649927 Temporal Stability and Molecular Persistence of the Bone Marrow Plasma Cell Antibody Repertoire Nature Communications. Dec, 2016 | Pubmed ID: 28000661 Local Control With 21-Gy Radiation Therapy for High-Risk Neuroblastoma International Journal of Radiation Oncology, Biology, Physics. Oct, 2016 | Pubmed ID: 27473818 Successful Engineering of a Highly Potent Single-chain Variable-fragment (scFv) Bispecific Antibody to Target Disialoganglioside (GD2) Positive Tumors Oncoimmunology. Jun, 2016 | Pubmed ID: 27471647 Oncotargets GD2 and GD3 Are Highly Expressed in Sarcomas of Children, Adolescents, and Young Adults Pediatric Blood & Cancer. Oct, 2016 | Pubmed ID: 27304202 Antitumor Efficacy of Anti-GD2 IgG1 Is Enhanced by Fc Glyco-Engineering Cancer Immunology Research. Jul, 2016 | Pubmed ID: 27197064 KIR3DL1 Allelic Polymorphism and HLA-B Epitopes Modulate Response to Anti-GD2 Monoclonal Antibody in Patients With Neuroblastoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jul, 2016 | Pubmed ID: 27069083 Arsenic Trioxide As a Radiation Sensitizer for 131I-Metaiodobenzylguanidine Therapy: Results of a Phase II Study Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Feb, 2016 | Pubmed ID: 26742708 Lack of Survival Advantage with Autologous Stem-cell Transplantation in High-risk Neuroblastoma Consolidated by Anti-GD2 Immunotherapy and Isotretinoin Oncotarget. Jan, 2016 | Pubmed ID: 26623730 Theranostic Pretargeted Radioimmunotherapy of Colorectal Cancer Xenografts in Mice Using Picomolar Affinity ⁸⁶Y- or ¹⁷⁷Lu-DOTA-Bn Binding ScFv C825/GPA33 IgG Bispecific Immunoconjugates European Journal of Nuclear Medicine and Molecular Imaging. May, 2016 | Pubmed ID: 26596724 Humanized Affinity-matured Monoclonal Antibody 8H9 Has Potent Antitumor Activity and Binds to FG Loop of Tumor Antigen B7-H3 The Journal of Biological Chemistry. Dec, 2015 | Pubmed ID: 26487718 Generation of TCR-Like Antibodies Using Phage Display Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 26424273 Anti-proliferative and Pro-apoptotic Activity of GD2 Ganglioside-specific Monoclonal Antibody 3F8 in Human Melanoma Cells Oncoimmunology. Aug, 2015 | Pubmed ID: 26405581 A Distinct Gene Expression Signature Characterizes Human Neuroblastoma Cancer Stem Cells Stem Cell Research. Sep, 2015 | Pubmed ID: 26342562 Immunotherapy of Childhood Sarcomas Frontiers in Oncology. 2015 | Pubmed ID: 26301204 Prolonged Progression-free Survival After Consolidating Second or Later Remissions of Neuroblastoma with Anti-G Immunotherapy and Isotretinoin: a Prospective Phase II Study Oncoimmunology. Jul, 2015 | Pubmed ID: 26140243 Human Derived Dimerization Tag Enhances Tumor Killing Potency of a T-cell Engaging Bispecific Antibody Oncoimmunology. Apr, 2015 | Pubmed ID: 26137406 Radioimmunotherapy of Human Tumours Nature Reviews. Cancer. Jun, 2015 | Pubmed ID: 25998714 Low Incidence of Radionecrosis in Children Treated with Conventional Radiation Therapy and Intrathecal Radioimmunotherapy Journal of Neuro-oncology. Jun, 2015 | Pubmed ID: 25944385 A Dual-specific Anti-IGF-1/IGF-2 Human Monoclonal Antibody Alone and in Combination with Temsirolimus for Therapy of Neuroblastoma International Journal of Cancer. Nov, 2015 | Pubmed ID: 25924852 Alteration of Electrostatic Surface Potential Enhances Affinity and Tumor Killing Properties of Anti-ganglioside GD2 Monoclonal Antibody Hu3F8 The Journal of Biological Chemistry. May, 2015 | Pubmed ID: 25851904 Chimeric Antigen Receptors and Bispecific Antibodies to Retarget T Cells in Pediatric Oncology Pediatric Blood & Cancer. Aug, 2015 | Pubmed ID: 25832831 Osteochondroma in Long-term Survivors of High-risk Neuroblastoma Cancer. Jun, 2015 | Pubmed ID: 25728463 Disialoganglioside GD2 As a Therapeutic Target for Human Diseases Expert Opinion on Therapeutic Targets. Mar, 2015 | Pubmed ID: 25604432 Bone Marrow Minimal Residual Disease Was an Early Response Marker and a Consistent Independent Predictor of Survival After Anti-GD2 Immunotherapy Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2015 | Pubmed ID: 25559819 Retargeting T Cells to GD2 Pentasaccharide on Human Tumors Using Bispecific Humanized Antibody Cancer Immunology Research. Mar, 2015 | Pubmed ID: 25542634 Antibody Induced Pain in Children: An Opportunity to Study Pain Mechanism, IgG Design and Analgesics Pediatric Blood & Cancer. Feb, 2015 | Pubmed ID: 25382406 Structural Design of Disialoganglioside GD2 and CD3-bispecific Antibodies to Redirect T Cells for Tumor Therapy International Journal of Cancer. Jan, 2015 | Pubmed ID: 24895182 GD2-targeted Immunotherapy and Radioimmunotherapy Seminars in Oncology. Oct, 2014 | Pubmed ID: 25440605 When Overall Survival Fails to Confirm Event-free Survival, Should the Latter Be Used to Set the Standard of Care? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2014 | Pubmed ID: 25403224 Structure Based Refinement of a Humanized Monoclonal Antibody That Targets Tumor Antigen Disialoganglioside GD2 Frontiers in Immunology. 2014 | Pubmed ID: 25177320 Deep MicroRNA Sequencing Reveals Downregulation of MiR-29a in Neuroblastoma Central Nervous System Metastasis Genes, Chromosomes & Cancer. Oct, 2014 | Pubmed ID: 24898736 Striking Dichotomy in Outcome of MYCN-amplified Neuroblastoma in the Contemporary Era Cancer. Jul, 2014 | Pubmed ID: 24691684 Key Role for Myeloid Cells: Phase II Results of Anti-G(D2) Antibody 3F8 Plus Granulocyte-macrophage Colony-stimulating Factor for Chemoresistant Osteomedullary Neuroblastoma International Journal of Cancer. Nov, 2014 | Pubmed ID: 24644014 Imaging the Norepinephrine Transporter in Neuroblastoma: a Comparison of [18F]-MFBG and 123I-MIBG Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2014 | Pubmed ID: 24573553 Phase I Trial of a Bivalent Gangliosides Vaccine in Combination with β-glucan for High-risk Neuroblastoma in Second or Later Remission Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2014 | Pubmed ID: 24520094 Engineering Anti-GD2 Monoclonal Antibodies for Cancer Immunotherapy FEBS Letters. Jan, 2014 | Pubmed ID: 24295643 Recurrent Pre-existing and Acquired DNA Copy Number Alterations, Including Focal TERT Gains, in Neuroblastoma Central Nervous System Metastases Genes, Chromosomes & Cancer. Dec, 2013 | Pubmed ID: 24123354 Anti-GD2 Antibody 3F8 and Barley-derived (1 → 3),(1 → 4)-β-D-glucan: A Phase I Study in Patients with Chemoresistant Neuroblastoma Oncoimmunology. Mar, 2013 | Pubmed ID: 23802080 Neuroblastoma: Developmental Biology, Cancer Genomics and Immunotherapy Nature Reviews. Cancer. Jun, 2013 | Pubmed ID: 23702928 In Silico Driven Redesign of a Clinically Relevant Antibody for the Treatment of GD2 Positive Tumors PloS One. 2013 | Pubmed ID: 23696816 Posterior Reversible Encephalopathy Syndrome in Neuroblastoma Patients Receiving Anti-GD2 3F8 Monoclonal Antibody Cancer. Aug, 2013 | Pubmed ID: 23633099 Early Negative Minimal Residual Disease in Bone Marrow After Immunotherapy is Less Predictive of Late or Non-marrow Relapse Among Patients with High-risk Stage 4 Neuroblastoma Pediatric Blood & Cancer. Jul, 2013 | Pubmed ID: 23335404 Ifosfamide, Carboplatin, and Etoposide for Neuroblastoma: a High-dose Salvage Regimen and Review of the Literature Cancer. Feb, 2013 | Pubmed ID: 22951749 Murine Anti-GD2 Monoclonal Antibody 3F8 Combined with Granulocyte-macrophage Colony-stimulating Factor and 13-cis-retinoic Acid in High-risk Patients with Stage 4 Neuroblastoma in First Remission Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Sep, 2012 | Pubmed ID: 22869886 Unlicensed NK Cells Target Neuroblastoma Following Anti-GD2 Antibody Treatment The Journal of Clinical Investigation. Sep, 2012 | Pubmed ID: 22863621 Humanizing Murine IgG3 Anti-GD2 Antibody M3F8 Substantially Improves Antibody-dependent Cell-mediated Cytotoxicity While Retaining Targeting in Vivo Oncoimmunology. Jul, 2012 | Pubmed ID: 22754766 Anti-CD3 × anti-GD2 Bispecific Antibody Redirects T-cell Cytolytic Activity to Neuroblastoma Targets Pediatric Blood & Cancer. Dec, 2012 | Pubmed ID: 22707078 Association of Age at Diagnosis and Genetic Mutations in Patients with Neuroblastoma JAMA. Mar, 2012 | Pubmed ID: 22416102 Activation of Peripheral-blood Granulocytes is Strongly Correlated with Patient Outcome After Immunotherapy with Anti-GD2 Monoclonal Antibody and Granulocyte-macrophage Colony-stimulating Factor Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2012 | Pubmed ID: 22203761 Plerixafor Plus Granulocyte-colony Stimulating Factor for Autologous Hematopoietic Stem Cell Mobilization in Patients with Metastatic Neuroblastoma Pediatric Blood & Cancer. Mar, 2012 | Pubmed ID: 21416584 MYCN and MYC Regulate Tumor Proliferation and Tumorigenesis Directly Through BMI1 in Human Neuroblastomas FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2011 | Pubmed ID: 21856782 Successful Multifold Dose Escalation of Anti-GD2 Monoclonal Antibody 3F8 in Patients with Neuroblastoma: a Phase I Study Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2011 | Pubmed ID: 21343563 Resectability and Operative Morbidity After Chemotherapy in Neuroblastoma Patients with Encasement of Major Visceral Arteries Journal of Pediatric Surgery. Jan, 2011 | Pubmed ID: 21238649 Checkpoint Kinase Inhibitor Synergizes with DNA-damaging Agents in G1 Checkpoint-defective Neuroblastoma International Journal of Cancer. Oct, 2011 | Pubmed ID: 21154747 High-dose Carboplatin-irinotecan-temozolomide: Treatment Option for Neuroblastoma Resistant to Topotecan Pediatric Blood & Cancer. Mar, 2011 | Pubmed ID: 21049517 Two-compartment Model of Radioimmunotherapy Delivered Through Cerebrospinal Fluid European Journal of Nuclear Medicine and Molecular Imaging. Feb, 2011 | Pubmed ID: 20936407 High-dose Cyclophosphamide-irinotecan-vincristine for Primary Refractory Neuroblastoma European Journal of Cancer (Oxford, England : 1990). Jan, 2011 | Pubmed ID: 20934323 Preliminary Results of a Phase I Trial of Prophylactic Ethanol-lock Administration to Prevent Mediport Catheter-related Bloodstream Infections Journal of Pediatric Surgery. Oct, 2010 | Pubmed ID: 20920713 Differential Impact of High-dose Cyclophosphamide, Topotecan, and Vincristine in Clinical Subsets of Patients with Chemoresistant Neuroblastoma Cancer. Jun, 2010 | Pubmed ID: 20564411 Neuroblastoma: Therapeutic Strategies for a Clinical Enigma Cancer Treatment Reviews. Jun, 2010 | Pubmed ID: 20227189 Whole Neuraxis Irradiation to Address Central Nervous System Relapse in High-risk Neuroblastoma International Journal of Radiation Oncology, Biology, Physics. Nov, 2010 | Pubmed ID: 20207502 High Frequency of P53/MDM2/p14ARF Pathway Abnormalities in Relapsed Neuroblastoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2010 | Pubmed ID: 20145180 Compartmental Intrathecal Radioimmunotherapy: Results for Treatment for Metastatic CNS Neuroblastoma Journal of Neuro-oncology. May, 2010 | Pubmed ID: 19890606 Analysis of GD2/GM2 Synthase MRNA As a Biomarker for Small Cell Lung Cancer Lung Cancer (Amsterdam, Netherlands). Feb, 2010 | Pubmed ID: 19457569 KIR and HLA Genotypes Are Associated with Disease Progression and Survival Following Autologous Hematopoietic Stem Cell Transplantation for High-risk Neuroblastoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2009 | Pubmed ID: 19934297 Reducing Epitope Spread During Affinity Maturation of an Anti-ganglioside GD2 Antibody Journal of Immunology (Baltimore, Md. : 1950). Nov, 2009 | Pubmed ID: 19812201 A Focal Lesion in the Falx Cerebri: Harbinger of Classic Stage 4 Neuroblastoma in an Infant Cured Despite Residual Disease After Minimal Therapy Pediatric Blood & Cancer. Dec, 2009 | Pubmed ID: 19711437 MicroRNA MiR-29 Modulates Expression of Immunoinhibitory Molecule B7-H3: Potential Implications for Immune Based Therapy of Human Solid Tumors Cancer Research. Aug, 2009 | Pubmed ID: 19584290 Hyperfractionated Low-dose (21 Gy) Radiotherapy for Cranial Skeletal Metastases in Patients with High-risk Neuroblastoma International Journal of Radiation Oncology, Biology, Physics. Nov, 2009 | Pubmed ID: 19427746 Monoclonal Antibody Therapies for Solid Tumors Expert Opinion on Biological Therapy. Mar, 2009 | Pubmed ID: 19216623 Specific Gene Expression Profiles and Chromosomal Abnormalities Are Associated with Infant Disseminated Neuroblastoma BMC Cancer. Feb, 2009 | Pubmed ID: 19192278 Sensitivity of Surveillance Studies for Detecting Asymptomatic and Unsuspected Relapse of High-risk Neuroblastoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2009 | Pubmed ID: 19171710 Reduced Risk of Secondary Leukemia with Fewer Cycles of Dose-intensive Induction Chemotherapy in Patients with Neuroblastoma Pediatric Blood & Cancer. Jul, 2009 | Pubmed ID: 19148951 Methionine Depletion with Recombinant Methioninase: in Vitro and in Vivo Efficacy Against Neuroblastoma and Its Synergism with Chemotherapeutic Drugs International Journal of Cancer. Apr, 2009 | Pubmed ID: 19089915 Management and Outcome of Stage 3 Neuroblastoma European Journal of Cancer (Oxford, England : 1990). Jan, 2009 | Pubmed ID: 18996003 Exploiting Gene Expression Profiling to Identify Novel Minimal Residual Disease Markers of Neuroblastoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2008 | Pubmed ID: 18980998 Solitary Relapse of Desmoplastic Small Round Cell Tumor Detected by Positron Emission Tomography/computed Tomography Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2008 | Pubmed ID: 18809603 Recurrent Metastatic Neuroblastoma Followed by Myelodysplastic Syndrome: Possible Leukemogenic Role of Temozolomide Pediatric Blood & Cancer. Oct, 2008 | Pubmed ID: 18570300 Prospective Tracing of MLL-FRYL Clone with Low MEIS1 Expression from Emergence During Neuroblastoma Treatment to Diagnosis of Myelodysplastic Syndrome Blood. Apr, 2008 | Pubmed ID: 18195096 Transient Sialoadenitis: a Complication of 131I-metaiodobenzylguanidine Therapy Pediatric Blood & Cancer. Jun, 2008 | Pubmed ID: 17973318 Brain-sparing Radiotherapy for Neuroblastoma Skull Metastases Pediatric Blood & Cancer. Jun, 2008 | Pubmed ID: 17973314 Distinct FAK-Src Activation Events Promote Alpha5beta1 and Alpha4beta1 Integrin-stimulated Neuroblastoma Cell Motility Oncogene. Feb, 2008 | Pubmed ID: 17828307 Novel Markers of Subclinical Disease for Ewing Family Tumors from Gene Expression Profiling Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2007 | Pubmed ID: 18056173 Phase I Study of Targeted Radioimmunotherapy for Leptomeningeal Cancers Using Intra-Ommaya 131-I-3F8 Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2007 | Pubmed ID: 18048828 Induction for High-risk Neuroblastoma Pediatric Blood & Cancer. Sep, 2007 | Pubmed ID: 17417798 Cyclin D1, a Novel Molecular Marker of Minimal Residual Disease, in Metastatic Neuroblastoma The Journal of Molecular Diagnostics : JMD. Apr, 2007 | Pubmed ID: 17384216 Disialoganglioside Directed Immunotherapy of Neuroblastoma Cancer Investigation. Feb, 2007 | Pubmed ID: 17364560 High-dose Cyclophosphamide Inhibition of Humoral Immune Response to Murine Monoclonal Antibody 3F8 in Neuroblastoma Patients: Broad Implications for Immunotherapy Pediatric Blood & Cancer. Apr, 2007 | Pubmed ID: 16421906 Irinotecan Plus Temozolomide for Relapsed or Refractory Neuroblastoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2006 | Pubmed ID: 17114661 Ototoxicity from High-dose Use of Platinum Compounds in Patients with Neuroblastoma Cancer. Jul, 2006 | Pubmed ID: 16779793 What Factors Predict a Favorable Outcome in Young Children with Disseminated Neuroblastoma? Nature Clinical Practice. Oncology. May, 2006 | Pubmed ID: 16683000 FCGR2A Polymorphism is Correlated with Clinical Outcome After Immunotherapy of Neuroblastoma with Anti-GD2 Antibody and Granulocyte Macrophage Colony-stimulating Factor Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jun, 2006 | Pubmed ID: 16682723 Exploiting the MIBG-avidity of Neuroblastoma for Staging and Treatment Pediatric Blood & Cancer. Dec, 2006 | Pubmed ID: 16544298 Sialyltransferase STX (ST8SiaII): a Novel Molecular Marker of Metastatic Neuroblastoma International Journal of Cancer. Jul, 2006 | Pubmed ID: 16450393 Liver Involvement in Neuroblastoma: the Memorial Sloan-Kettering Experience Supports Treatment Reduction in Young Patients Pediatric Blood & Cancer. Mar, 2006 | Pubmed ID: 16124002 Neuroblastoma--from Genetic Profiles to Clinical Challenge The New England Journal of Medicine. Nov, 2005 | Pubmed ID: 16306518 Radioimmunotargeting of Human Rhabdomyosarcoma Using Monoclonal Antibody 8H9 Cancer Biotherapy & Radiopharmaceuticals. Oct, 2005 | Pubmed ID: 16248769 Prognostic Value of MYCN and ID2 Overexpression in Neuroblastoma Pediatric Blood & Cancer. Dec, 2005 | Pubmed ID: 16047351 Rituximab Therapy of Lymphoma is Enhanced by Orally Administered (1-->3),(1-->4)-D-beta-glucan Leukemia Research. Jun, 2005 | Pubmed ID: 15863209 Long-term Complications in Survivors of Advanced Stage Neuroblastoma Pediatric Blood & Cancer. Sep, 2005 | Pubmed ID: 15714447 Antibody-based Targeted Radiation to Pediatric Tumors Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jan, 2005 | Pubmed ID: 15653664 Five-day Courses of Irinotecan As Palliative Therapy for Patients with Neuroblastoma Cancer. Feb, 2005 | Pubmed ID: 15637685 Characteristics of Stem Cells from Human Neuroblastoma Cell Lines and in Tumors Neoplasia (New York, N.Y.). 2004 | Pubmed ID: 15720811 Reduction from Seven to Five Cycles of Intensive Induction Chemotherapy in Children with High-risk Neuroblastoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2004 | Pubmed ID: 15611504 Treatment of Neuroblastoma Meningeal Carcinomatosis with Intrathecal Application of Alpha-emitting Atomic Nanogenerators Targeting Disialo-ganglioside GD2 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2004 | Pubmed ID: 15501978 Measuring Circulating Neuroblastoma Cells by Quantitative Reverse Transcriptase-polymerase Chain Reaction Analysis Cancer. Nov, 2004 | Pubmed ID: 15484213 Treatment Reduction for Neuroblastoma Pediatric Blood & Cancer. Nov, 2004 | Pubmed ID: 15390354 Single-chain Fv-streptavidin Substantially Improved Therapeutic Index in Multistep Targeting Directed at Disialoganglioside GD2 Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. May, 2004 | Pubmed ID: 15136638 The Impact of Gross Total Resection on Local Control and Survival in High-risk Neuroblastoma Journal of Pediatric Surgery. Mar, 2004 | Pubmed ID: 15017562 Pharmacokinetics, Dosimetry, and Toxicity of the Targetable Atomic Generator, 225Ac-HuM195, in Nonhuman Primates Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jan, 2004 | Pubmed ID: 14734685 Camptothecin Analogs (irinotecan or Topotecan) Plus High-dose Cyclophosphamide As Preparative Regimens for Antibody-based Immunotherapy in Resistant Neuroblastoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2004 | Pubmed ID: 14734455 Radically Different Treatment Recommendations for Newly Diagnosed Neuroblastoma: Pitfalls in Assessment of Risk Journal of Pediatric Hematology/oncology. Jan, 2004 | Pubmed ID: 14707711 Treatment of Spinal Involvement in Neuroblastoma Patients Pediatric Neurosurgery. Dec, 2003 | Pubmed ID: 14734862 Neuroblastoma in Adolescents and Adults: the Memorial Sloan-Kettering Experience Medical and Pediatric Oncology. Dec, 2003 | Pubmed ID: 14595707 Early Molecular Response of Marrow Disease to Biologic Therapy is Highly Prognostic in Neuroblastoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2003 | Pubmed ID: 14551304 Anti-idiotypic Antibody Facilitates ScFv Chimeric Immune Receptor Gene Transduction and Clonal Expansion of Human Lymphocytes for Tumor Therapy Hybridoma and Hybridomics. Aug, 2003 | Pubmed ID: 14511566 Genome-wide Analysis of Gene Expression Associated with MYCN in Human Neuroblastoma Cancer Research. Aug, 2003 | Pubmed ID: 12907629 Oral Topotecan for Refractory and Relapsed Neuroblastoma: a Retrospective Analysis Journal of Pediatric Hematology/oncology. Aug, 2003 | Pubmed ID: 12902911 Curability of Recurrent Disseminated Disease After Surgery Alone for Local-regional Neuroblastoma Using Intensive Chemotherapy and Anti-G(D2) Immunotherapy Journal of Pediatric Hematology/oncology. Jul, 2003 | Pubmed ID: 12847316 Tumor Lysis Syndrome, Neuroblastoma, and Correlation Between Serum Lactate Dehydrogenase Levels and MYCN-amplification Medical and Pediatric Oncology. Jul, 2003 | Pubmed ID: 12764755 Quantitation of GD2 Synthase MRNA by Real-time Reverse Transcriptase Polymerase Chain Reaction: Clinical Utility in Evaluating Adjuvant Therapy in Neuroblastoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2003 | Pubmed ID: 12637475 Impact of Metaiodobenzylguanidine Scintigraphy on Assessing Response of High-risk Neuroblastoma to Dose-intensive Induction Chemotherapy Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2003 | Pubmed ID: 12637474 Anti-idiotypic Antibody As the Surrogate Antigen for Cloning ScFv and Its Fusion Proteins Hybridoma and Hybridomics. Dec, 2002 | Pubmed ID: 12573107 Orally Administered Beta-glucans Enhance Anti-tumor Effects of Monoclonal Antibodies Cancer Immunology, Immunotherapy : CII. Nov, 2002 | Pubmed ID: 12384807 Disialoganglioside GD2 and a Novel Tumor Antigen: Potential Targets for Immunotherapy of Desmoplastic Small Round Cell Tumor Medical and Pediatric Oncology. Dec, 2002 | Pubmed ID: 12376975 Chronic Neuroblastoma Cancer. Sep, 2002 | Pubmed ID: 12216106 Evolving Significance of Prognostic Markers Associated with Treatment Improvement in Patients with Stage 4 Neuroblastoma Cancer. May, 2002 | Pubmed ID: 12173347 Quantitation of GD2 Synthase MRNA by Real-time Reverse Transcription-polymerase Chain Reaction: Utility in Bone Marrow Purging of Neuroblastoma by Anti-GD2 Antibody 3F8 Cancer. Jun, 2002 | Pubmed ID: 12115395 Oral (1-->3),(1-->4)-beta-D-glucan Synergizes with Antiganglioside GD2 Monoclonal Antibody 3F8 in the Therapy of Neuroblastoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2002 | Pubmed ID: 12006541 Panhandle and Reverse-panhandle PCR Enable Cloning of Der(11) and Der(other) Genomic Breakpoint Junctions of MLL Translocations and Identify Complex Translocation of MLL, AF-4, and CDK6 Proceedings of the National Academy of Sciences of the United States of America. Apr, 2002 | Pubmed ID: 11930009 Novel Regions of Allelic Imbalance Identified by Genome-wide Analysis of Neuroblastoma Cancer Research. Mar, 2002 | Pubmed ID: 11912152 Clinical Categories of Neuroblastoma Are Associated with Different Patterns of Loss of Heterozygosity on Chromosome Arm 1p The Journal of Molecular Diagnostics : JMD. Feb, 2000 | Pubmed ID: 11272900 Implications of EPHB6, EFNB2, and EFNB3 Expressions in Human Neuroblastoma Proceedings of the National Academy of Sciences of the United States of America. Sep, 2000 | Pubmed ID: 10984508 Detection of Leukemia-associated MLL-GAS7 Translocation Early During Chemotherapy with DNA Topoisomerase II Inhibitors Proceedings of the National Academy of Sciences of the United States of America. Mar, 2000 | Pubmed ID: 10706619 Surface Antigen Expression and Complement Susceptibility of Differentiated Neuroblastoma Clones The American Journal of Pathology. Mar, 2000 | Pubmed ID: 10702424 Association of CYP3A4 Genotype with Treatment-related Leukemia Proceedings of the National Academy of Sciences of the United States of America. Oct, 1998 | Pubmed ID: 9789061 Antigen-dependent CD28 Signaling Selectively Enhances Survival and Proliferation in Genetically Modified Activated Human Primary T Lymphocytes The Journal of Experimental Medicine. Aug, 1998 | Pubmed ID: 9705944 Tracking Bispecific Antibody-Induced T Cell Trafficking Using Luciferase-Transduced Human T Cells Madelyn Espinosa-Cotton1, Hong-Fen Guo1, Nai-Kong V. Cheung1 1Department of Pediatrics, Memorial Sloan Kettering Cancer Center JoVE 64390 Ricerca sul cancro
Tracking Bispecific Antibody-Induced T Cell Trafficking Using Luciferase-Transduced Human T Cells Madelyn Espinosa-Cotton1, Hong-Fen Guo1, Nai-Kong V. Cheung1 1Department of Pediatrics, Memorial Sloan Kettering Cancer Center JoVE 64390 Ricerca sul cancro