Ryota Hokari Department of internal medicine National Defense Medical College Biography Publications Institution JoVE Articles Ryota Hokari has not added a biography. If you are Ryota Hokari and would like to personalize this page please email our Author Liaison for assistance. Publications Redox-dependent PPARγ/Tnpo1 Complex Formation Enhances PPARγ Nuclear Localization and Signaling Free Radical Biology & Medicine. Jun, 2020 | Pubmed ID: 32553752 Very Early-onset Inflammatory Bowel Disease in Japan: A Nationwide Survey Journal of Gastroenterology and Hepatology. Jun, 2020 | Pubmed ID: 32530546 Non-adherence to Medications in Pregnant Ulcerative Colitis Patients Contributes to Disease Flares and Adverse Pregnancy Outcomes Digestive Diseases and Sciences. Apr, 2020 | Pubmed ID: 32249373 [Role of Immunomodulators on Treatment of Patients with Inflammatory Bowel Diseases in Special Occasions, Pregnancy or Elderly] Nihon Shokakibyo Gakkai Zasshi = The Japanese Journal of Gastro-enterology. 2020 | Pubmed ID: 32161244 Significance of Conducting 2 Types of Fecal Tests in Patients With Ulcerative Colitis Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. May, 2020 | Pubmed ID: 31394288 Dietary Emulsifier Polysorbate-80-induced Small-intestinal Vulnerability to Indomethacin-induced Lesions Via Dysbiosis Journal of Gastroenterology and Hepatology. Jan, 2020 | Pubmed ID: 31359491 Biliary Tract Bleeding with Obstructive Jaundice After Endoscopic Ultrasound-guided Fine-needle Aspiration of a Pancreatic Head Tumor Clinical Journal of Gastroenterology. Feb, 2020 | Pubmed ID: 31165459 Correction To: Management of Elderly Ulcerative Colitis in Japan Journal of Gastroenterology. Oct, 2019 | Pubmed ID: 31392487 Lipoprotein Lipase Up-regulation in Hepatic Stellate Cells Exacerbates Liver Fibrosis in Nonalcoholic Steatohepatitis in Mice Hepatology Communications. Aug, 2019 | Pubmed ID: 31388630 Chitinase 3-like 1 Deficiency Ameliorates Liver Fibrosis by Promoting Hepatic Macrophage Apoptosis Hepatology Research : the Official Journal of the Japan Society of Hepatology. Nov, 2019 | Pubmed ID: 31250532 Management of Elderly Ulcerative Colitis in Japan Journal of Gastroenterology. Jul, 2019 | Pubmed ID: 31025187 Crohn's Disease Accompanied with Small Intestinal Extramedullary Plasmacytoma Internal Medicine (Tokyo, Japan). Jul, 2019 | Pubmed ID: 30918171 Depression Promotes the Onset of Irritable Bowel Syndrome Through Unique Dysbiosis in Rats Gut and Liver. 05, 2019 | Pubmed ID: 30602220 Atypical Clinical Presentation of Crohn's Disease with Superior Mesenteric Vein Obstruction and Protein-losing Enteropathy Internal Medicine (Tokyo, Japan). Feb, 2019 | Pubmed ID: 30210116 NUDT15 Codon 139 is the Best Pharmacogenetic Marker for Predicting Thiopurine-induced Severe Adverse Events in Japanese Patients with Inflammatory Bowel Disease: a Multicenter Study Journal of Gastroenterology. Sep, 2018 | Pubmed ID: 29923122 Nicotine Treatment Ameliorates DSS-induced Colitis by Suppressing MAdCAM-1 Expression and Leukocyte Recruitment Journal of Leukocyte Biology. 11, 2018 | Pubmed ID: 29901817 Predicting Outcomes to Optimize Disease Management in Inflammatory Bowel Disease in Japan: Their Differences and Similarities to Western Countries Intestinal Research. Apr, 2018 | Pubmed ID: 29743830 Clinical Differences Between Elderly-onset Ulcerative Colitis and Non-elderly-onset Ulcerative Colitis: A Nationwide Survey Data in Japan Journal of Gastroenterology and Hepatology. Nov, 2018 | Pubmed ID: 29669163 Aortic Carboxypeptidase-like Protein, a WNT Ligand, Exacerbates Nonalcoholic Steatohepatitis The Journal of Clinical Investigation. 04, 2018 | Pubmed ID: 29553485 Safety and Efficacy of Leukocytapheresis in Elderly Patients with Ulcerative Colitis: The Impact in Steroid-free Elderly Patients Journal of Gastroenterology and Hepatology. Aug, 2018 | Pubmed ID: 29406567 Amelioration of Colitis Through Blocking Lymphocytes Entry to Peyer's Patches by Sphingosine-1-phosphate Lyase Inhibitor Journal of Gastroenterology and Hepatology. Jan, 2018 | Pubmed ID: 29336057 Vitamin A-coupled Liposome System Targeting Free Cholesterol Accumulation in Hepatic Stellate Cells Offers a Beneficial Therapeutic Strategy for Liver Fibrosis Hepatology Research : the Official Journal of the Japan Society of Hepatology. Apr, 2018 | Pubmed ID: 29243365 Human Intestinal Spirochetosis Mimicking Ulcerative Colitis Clinical Journal of Gastroenterology. Apr, 2018 | Pubmed ID: 29204849 Evaluation by MR Enterocolonography of Lansoprazole-induced Collagenous Colitis Accompanied with Protein-losing Enteropathy Internal Medicine (Tokyo, Japan). Jan, 2018 | Pubmed ID: 29033425 Novel Probiotics Isolated from a Japanese Traditional Fermented Food, Funazushi, Attenuates DSS-induced Colitis by Increasing the Induction of High Integrin αv/β8-expressing Dendritic Cells Journal of Gastroenterology. Mar, 2018 | Pubmed ID: 28631049 Mogamulizumab-induced Toxicoderma-like Eruptions and Autoimmune Hepatitis Successfully Treated with Azathioprine in Adult T-cell Leukaemia/lymphoma European Journal of Dermatology : EJD. 12, 2017 | Pubmed ID: 28739547 Free Cholesterol Accumulation in Liver Sinusoidal Endothelial Cells Exacerbates Acetaminophen Hepatotoxicity Via TLR9 Signaling Journal of Hepatology. 10, 2017 | Pubmed ID: 28554874 Uric Acid Ameliorates Indomethacin-induced Enteropathy in Mice Through Its Antioxidant Activity Journal of Gastroenterology and Hepatology. Nov, 2017 | Pubmed ID: 28295549 Other Polyposis Syndrome -report from Japanese Nationwide Survey of Cronkhite-Canada Syndrome Nihon Shokakibyo Gakkai Zasshi = The Japanese Journal of Gastro-enterology. 2017 | Pubmed ID: 28260710 Psychological Stress Exacerbates NSAID-induced Small Bowel Injury by Inducing Changes in Intestinal Microbiota and Permeability Via Glucocorticoid Receptor Signaling Journal of Gastroenterology. Jan, 2017 | Pubmed ID: 27075753 Hyperuricemia in Acute Gastroenteritis is Caused by Decreased Urate Excretion Via ABCG2 Scientific Reports. 08, 2016 | Pubmed ID: 27571712 Antibiotics Suppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats Gastroenterology. 11, 2016 | Pubmed ID: 27436071 Small Intestinal Crohn's Disease with Hepatic Portal Venous Gas: a Case Report Surgical Case Reports. Dec, 2016 | Pubmed ID: 27352296 Platelet Interaction with Lymphatics Aggravates Intestinal Inflammation by Suppressing Lymphangiogenesis American Journal of Physiology. Gastrointestinal and Liver Physiology. 08, 2016 | Pubmed ID: 27313177 Pregnancy Outcome in Women with Inflammatory Bowel Disease Treated with Anti-tumor Necrosis Factor And/or Thiopurine Therapy: a Multicenter Study from Japan Intestinal Research. Apr, 2016 | Pubmed ID: 27175114 Endoscopic and Clinical Evaluation of Treatment and Prognosis of Cronkhite-Canada Syndrome: a Japanese Nationwide Survey Journal of Gastroenterology. Apr, 2016 | Pubmed ID: 26216651 The Evolutionary Patterns of Hepatitis C Virus Subtype 2a and 6a Isolates Linked to an Outbreak in China in 2012 Virology. Nov, 2015 | Pubmed ID: 26343863 Recombinant Thrombomodulin Modulates Murine Colitis Possibly Via High-Mobility Group Box 1 Protein Inhibition Digestion. 2015 | Pubmed ID: 26302768 Lethal Hemorrhage from Duodenal Ulcer Due to Small Pancreatic Cancer Clinical Journal of Gastroenterology. Aug, 2015 | Pubmed ID: 26253020 Toll-like Receptor (TLR) 2 Agonists Ameliorate Indomethacin-induced Murine Ileitis by Suppressing the TLR4 Signaling Journal of Gastroenterology and Hepatology. Nov, 2015 | Pubmed ID: 25867219 No Contribution of the ABCB11 P.444A Polymorphism in Japanese Patients with Drug-induced Cholestasis Drug Metabolism and Disposition: the Biological Fate of Chemicals. May, 2015 | Pubmed ID: 25713208 Beneficial Effect of an Omega-6 PUFA-rich Diet in Non-steroidal Anti-inflammatory Drug-induced Mucosal Damage in the Murine Small Intestine World Journal of Gastroenterology. Jan, 2015 | Pubmed ID: 25574090 Magnetic Resonance Enterocolonography in Detecting Erosion and Redness in Intestinal Mucosa of Patients with Crohn's Disease Journal of Gastroenterology and Hepatology. Apr, 2015 | Pubmed ID: 25387770 Pregnant Woman with Non-comatose Autoimmune Acute Liver Failure in the Second Trimester Rescued Using Medical Therapy: A Case Report Hepatology Research : the Official Journal of the Japan Society of Hepatology. Mar, 2015 | Pubmed ID: 24739014 Acyl-CoA:cholesterol Acyltransferase 1 Mediates Liver Fibrosis by Regulating Free Cholesterol Accumulation in Hepatic Stellate Cells Journal of Hepatology. Jul, 2014 | Pubmed ID: 24657401 Chronic Antibiotic-refractory Diversion Pouchitis Successfully Treated with Leukocyteapheresis Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. Dec, 2014 | Pubmed ID: 24571541 Phlebosclerotic Colitis That Was Difficult to Distinguish from Collagenous Colitis Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society. Jul, 2014 | Pubmed ID: 23902595 Free Cholesterol Accumulation in Hepatic Stellate Cells: Mechanism of Liver Fibrosis Aggravation in Nonalcoholic Steatohepatitis in Mice Hepatology (Baltimore, Md.). Jan, 2014 | Pubmed ID: 23832448 Prevalence of Serum Celiac Antibody in Patients with IBD in Japan Journal of Gastroenterology. May, 2014 | Pubmed ID: 23754511 Effect of Dietary Fat on Intestinal Inflammatory Diseases Journal of Gastroenterology and Hepatology. Dec, 2013 | Pubmed ID: 24251701 Trans Fatty Acids in Diets Act As a Precipitating Factor for Gut Inflammation? Journal of Gastroenterology and Hepatology. Dec, 2013 | Pubmed ID: 24251700 1,4-Dihydroxy-2-naphthoic Acid from Propionibacterium Freudenreichii Reduces Inflammation in Interleukin-10-deficient Mice with Colitis by Suppressing Macrophage-derived Proinflammatory Cytokines Journal of Leukocyte Biology. Sep, 2013 | Pubmed ID: 23801651 Norovirus Binding to Intestinal Epithelial Cells is Independent of Histo-blood Group Antigens PloS One. 2013 | Pubmed ID: 23799113 [Functional Gastrointestinal Disorders (FGID): Progress in Diagnosis and Treatments. Topic II. Current Status and Future Prospective of Medical Care of the Representative Disorders; 5. Differential Diagnosis and Therapy for Functional Diarrhea and Functional Constipation] Nihon Naika Gakkai Zasshi. The Journal of the Japanese Society of Internal Medicine. Jan, 2013 | Pubmed ID: 23777118 [Revision of the Training Curriculum of Japan Society of Gastroenterology: Lower Gastrointestinal Tract] Nihon Shokakibyo Gakkai Zasshi = The Japanese Journal of Gastro-enterology. 05, 2013 | Pubmed ID: 23648535 Involvement of Autotaxin/lysophospholipase D Expression in Intestinal Vessels in Aggravation of Intestinal Damage Through Lymphocyte Migration Laboratory Investigation; a Journal of Technical Methods and Pathology. May, 2013 | Pubmed ID: 23478591 Endoscopic Finding of Spontaneous Hemorrhage Correlates with Tumor Necrosis Factor Alpha Expression in Colonic Mucosa of Patients with Ulcerative Colitis International Journal of Colorectal Disease. Aug, 2013 | Pubmed ID: 23377880 Dietary Lipids and Sweeteners Regulate Glucagon-like Peptide-2 Secretion American Journal of Physiology. Gastrointestinal and Liver Physiology. Apr, 2013 | Pubmed ID: 23370677 Mucosal Immunity in Gut and Lymphoid Cell Trafficking Annals of Vascular Diseases. 2012 | Pubmed ID: 23555525 [Role of Blood Flow and Microcirculation Disturbance in Inflammatory Bowel Disease] Nihon Rinsho. Japanese Journal of Clinical Medicine. Feb, 2012 | Pubmed ID: 23126077 Indomethacin-induced Small Intestinal Injury is Ameliorated by Cilostazol, a Specific PDE-3 Inhibitor Scandinavian Journal of Gastroenterology. Sep, 2012 | Pubmed ID: 22934593 P53/p66Shc-mediated Signaling Contributes to the Progression of Non-alcoholic Steatohepatitis in Humans and Mice Journal of Hepatology. Oct, 2012 | Pubmed ID: 22641095 HIF-1 in T Cells Ameliorated Dextran Sodium Sulfate-induced Murine Colitis Journal of Leukocyte Biology. Jun, 2012 | Pubmed ID: 22457366 Physiological Stress Exacerbates Murine Colitis by Enhancing Proinflammatory Cytokine Expression That is Dependent on IL-18 American Journal of Physiology. Gastrointestinal and Liver Physiology. Sep, 2011 | Pubmed ID: 21719737 [Intestinal Homeostasis and Pathopysiology: Roles of Nutrient Sensing and Absorption] Nihon Naika Gakkai Zasshi. The Journal of the Japanese Society of Internal Medicine. Jan, 2011 | Pubmed ID: 21387645 Increased Expression of Lipocalin-type-prostaglandin D Synthase in Ulcerative Colitis and Exacerbating Role in Murine Colitis American Journal of Physiology. Gastrointestinal and Liver Physiology. Mar, 2011 | Pubmed ID: 21163901 Voltage-gated Potassium Channel Kv1.3 Blocker As a Potential Treatment for Rat Anti-glomerular Basement Membrane Glomerulonephritis American Journal of Physiology. Renal Physiology. Dec, 2010 | Pubmed ID: 20810612 Lemon Grass (Cymbopogon Citratus) Ameliorates Murine Spontaneous Ileitis by Decreasing Lymphocyte Recruitment to the Inflamed Intestine Microcirculation (New York, N.Y. : 1994). Jul, 2010 | Pubmed ID: 20618690 A Case of Intraductal Papillary Mucinous Neoplasm of the Pancreas Rupturing Both the Stomach and Duodenum Gastrointestinal Endoscopy. Feb, 2010 | Pubmed ID: 19922925 Cilostazol, a Specific PDE-3 Inhibitor, Ameliorates Chronic Ileitis Via Suppression of Interaction of Platelets with Monocytes American Journal of Physiology. Gastrointestinal and Liver Physiology. Dec, 2009 | Pubmed ID: 19815627 Increased Expression and Cellular Localization of Lipocalin-type Prostaglandin D Synthase in Helicobacter Pylori-induced Gastritis The Journal of Pathology. Dec, 2009 | Pubmed ID: 19768745 Blockade of B7-H1 or B7-DC Induces an Anti-tumor Effect in a Mouse Pancreatic Cancer Model International Journal of Oncology. Oct, 2009 | Pubmed ID: 19724910 Anti-inflammatory Effects of the Genus Bifidobacterium on Macrophages by Modification of Phospho-I KappaB and SOCS Gene Expression International Journal of Experimental Pathology. Apr, 2009 | Pubmed ID: 19335551 Oral Tolerance Induced by Enterobacteria Altered the Process of Lymphocyte Recruitment to Intestinal Microvessels: Roles of Endothelial Cell Adhesion Molecules, TGF-beta and Negative Regulators of TLR Signaling Microcirculation (New York, N.Y. : 1994). Apr, 2009 | Pubmed ID: 19225984 Long-term Outcome of Endoscopic Semiconductive Diode Laser Irradiation Therapy with Injection of Indocyanine Green for Early Gastric Cancer Journal of Gastroenterology and Hepatology. Aug, 2008 | Pubmed ID: 18624897 P-selectin-dependent Monocyte Recruitment Through Platelet Interaction in Intestinal Microvessels of LPS-treated Mice Microcirculation (New York, N.Y. : 1994). Jul, 2008 | Pubmed ID: 18574746 Omega-3 Fatty Acids Exacerbate DSS-induced Colitis Through Decreased Adiponectin in Colonic Subepithelial Myofibroblasts Inflammatory Bowel Diseases. Oct, 2008 | Pubmed ID: 18484673 Pressure Loading and Ethanol Exposure Differentially Modulate Rat Hepatic Stellate Cell Activation Journal of Cellular Physiology. May, 2008 | Pubmed ID: 18064666 Changes in Regulatory Molecules for Lymphangiogenesis in Intestinal Lymphangiectasia with Enteric Protein Loss Journal of Gastroenterology and Hepatology. Jul, 2008 | Pubmed ID: 18005011 Effects of Intratumoral Injection of CCL2 on Monocyte-endothelial Cell Interactions in Mouse Pancreatic Cancer Microcirculation (New York, N.Y. : 1994). Apr-May, 2007 | Pubmed ID: 17454676 Expression of PD-1, PD-L1, and PD-L2 in the Liver in Autoimmune Liver Diseases The American Journal of Gastroenterology. Feb, 2007 | Pubmed ID: 17311651 [A Case of Churg-Strauss Syndrome Discovered with Hematemesis] Nihon Shokakibyo Gakkai Zasshi = The Japanese Journal of Gastro-enterology. Dec, 2006 | Pubmed ID: 17148925 [Alcoholic Ketoacidosis with Severe Abdominal Pain] Nihon Naika Gakkai Zasshi. The Journal of the Japanese Society of Internal Medicine. Jul, 2006 | Pubmed ID: 16893031 Differential Modulation in the Functions of Intestinal Dendritic Cells by Long- and Medium-chain Fatty Acids Journal of Gastroenterology. Mar, 2006 | Pubmed ID: 16699854 Combination Therapy with Tumor-lysate Pulsed Dendritic Cells and Antiangiogenic Drug TNP-470 for Mouse Pancreatic Cancer International Journal of Cancer. Nov, 2005 | Pubmed ID: 15906361 Role of Nociceptin/orphanin FQ (Noc/oFQ) in Murine Experimental Colitis Journal of Neuroimmunology. Apr, 2005 | Pubmed ID: 15748940 Blockade of PSGL-1 Attenuates CD14+ Monocytic Cell Recruitment in Intestinal Mucosa and Ameliorates Ileitis in SAMP1/Yit Mice Journal of Leukocyte Biology. Mar, 2005 | Pubmed ID: 15569697 A Highly Hydrophobic Domain Within Hypervariable Region 1 May Be Related to the Entry of Hepatitis C Virus into Cultured Human Hepatoma Cells Journal of Medical Virology. Dec, 2004 | Pubmed ID: 15484277 Regulation of T-lymphocyte Trafficking by ICAM-1, MAdCAM-1, and CCR7 in Microcirculation of Appendicular and Intestinal Lymphoid Tissues Microcirculation (New York, N.Y. : 1994). Sep, 2004 | Pubmed ID: 15371130 Differential Expression of CCR5 and CRTH2 on Infiltrated Cells in Colonic Mucosa of Patients with Ulcerative Colitis Journal of Gastroenterology and Hepatology. Sep, 2003 | Pubmed ID: 12911667 Newly Designed Soft Prelooped Cap for Endoscopic Mucosal Resection of Gastric Lesions Gastrointestinal Endoscopy. Feb, 2003 | Pubmed ID: 12556795 Increased Expression of Galectin-3 in Primary Gastric Cancer and the Metastatic Lymph Nodes Oncology Reports. Nov-Dec, 2002 | Pubmed ID: 12375039 Microscopic Observation of Lymphocyte Dynamics in Rat Peyer's Patches Kazuhiko Shirakabe1,2, Masaaki Higashiyama1, Naoki Shibuya2, Kazuki Horiuchi1, Masayuki Saruta2, Ryota Hokari1 1Department of internal medicine, National Defense Medical College, 2Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine JoVE 61568 Medicina
Microscopic Observation of Lymphocyte Dynamics in Rat Peyer's Patches Kazuhiko Shirakabe1,2, Masaaki Higashiyama1, Naoki Shibuya2, Kazuki Horiuchi1, Masayuki Saruta2, Ryota Hokari1 1Department of internal medicine, National Defense Medical College, 2Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine JoVE 61568 Medicina